New luminol chemiluminescence reaction using diperiodatoargentate as oxidate for the determination of amikacin sulfate

Abstract

A new chemiluminescence (CL) reaction between luminol and diperiodatoargentate [K(2) [Ag (H(2)IO(6)) (OH)(2)]] was observed in alkaline medium. The CL intensity could be greatly enhanced by amikacin sulfate. Therefore a new CL method for the determination of amikacin sulfate was built by combining with flow injection technology. A possible mechanism of the CL reaction was proposed via the investigation of the CL kinetic characteristics, the CL spectrum and the UV absorption spectra of some related substance. The concentration range of linear response was 5.1 x 10(-8) to 5.1 x 10(-6)mol L(-1) with a detection limit of 1.9 x 10(-8) mol L(-1) (3sigma). The proposed method had good reproducibility with a relative standard deviation of 2.8% (n = 7) for 5.1 x 10(-7) mol L(-1) of amikacin sulfate. It was successfully applied to determine amikacin sulfate in serum.

Effect of colloidal β‐cyclodextrins–Fe3O4 magnetic nanoparticles on the chemiluminescence enhancement of luminol–Ag(III) complex for rapid and sensitive determination of cysteine in human serum

“…It was confirmed that in the CL reaction of luminol and DPA, the exited state of 3‐aminophthalate was an emitter . So, according to previous studies of the oxidation of amikacin sulphate, dopamine and paracetamol , the possible mechanism of the luminol–DPA–cysteine system in the absence of β ‐CD–Fe 3 O 4 MNPs inclusion complexes was proposed, and is shown in Scheme . In the prior equilibrium step 1, (OH – ] deprotonates the DPA to give a deprotonated diperiodatoargentate(III); in the second step, displacement of the ligand, periodate, takes place to give free periodate.…”

“…DPA complex was prepared according to the literature , with some modifications, such as using a micro‐filter to separate the precipitate, and shielding the solution container from light with aluminium foil during the heating process. Spectroscopic methods were used to confirm the synthesized complex.…”

Determination of aminoglycoside antibiotics using an on-chip microfluidic device with chemiluminescence detection

“…However, a relatively high LOD for amikacin was obtained by using the same CL system in a conventional FI method [22]. Conventional FI methods using other luminol systems have been also described for several individual AG antibiotics [26][27][28], but the method described here is the first one which uses a microfluidic system for AG determination using CL detection.…”

“…A comparison of the figures of merit of this work with those of other methods for the determination of aminoglycoside antibiotics involving CL detection [22,[24][25][26][27][28][29][30] is shown in Table 3. As can be seen, the luminol-hydrogen peroxideCu(II) system has been described for the CL detection of amikacin alone [24] and AG mixtures [25] by liquid chromatography, reaching very low LOD values in this last method, which includes a previous preconcentration step.…”

Oral Gentamicin Preparation Using Solidified Lipid Particulate Delivery System

“…A lot of researchers had employed various assay methods for determining some aminoglycosides including gentamicin in different delivery systems. These include: microbiological [5], polarographic [6], chemiluminescence [7], capillary electrophoresis [8], immunoassay [9], thin layer chromatographic [10], high performance liquid chromatographic [11], spectrofluorimetric [12], and spectrophotometric [13,14] methods.…”