New malignancy grading is a better prognostic indicator than Broders' grading in oral squamous cell carcinomas

Bryne, Magne; Koppang, Hanna Strömme; Lilleng, R; Stene, Torbjörn; Bang, Gisle; Dabelsteen, Erik

doi:10.1111/j.1600-0714.1989.tb01339.x

Cited by 308 publications

(320 citation statements)

References 6 publications

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“…Could these models be used to predict which low-stage patients are at risk for disease-progression? Tumor pattern of invasion at the tumor host interface is a consistent component of these models [11][12][13][14][15][16][17][18][19][20]. Other components have included lymphocytic host response, exophytic versus endophytic growth pattern, mitotic rate, degree of keratinization, and nuclear pleomorphism.…”

Section: Predictors Of Occult Metastases: Tumor Depth Of Invasionmentioning

confidence: 99%

“…This cumbersome system was modified into a four-variable four-tiered system by Bryne [12][13][14]16] Attempts at validating the Bryne model, and pattern of invasion as a single indicator, however, were not always successful. Problems with the validation studies included small sample size, heterogeneous tumor sites and primary treatment modalities, plus evaluation of different specimen types, as some studies evaluated only biopsies, others only resection specimens, and still others evaluated both biopsies and resection specimens.…”

Section: Predictors Of Occult Metastases: Tumor Depth Of Invasionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Brandwein-Gensler

Smith

2010

Head and Neck Pathol

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Section: Predictors Of Occult Metastases: Tumor Depth Of Invasionmentioning

confidence: 99%

Section: Predictors Of Occult Metastases: Tumor Depth Of Invasionmentioning

confidence: 99%

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Brandwein-Gensler

Smith

2010

Head and Neck Pathol

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“…Based on the histological grading proposed by Bryne et al 8 , two observers identified the front of tumor invasion (light microscopy -Olympus CX-31) and at a 1000x magnification and analyzed the presence or absence of immunostaining in the cell membrane, cytoplasm, nucleus or a combination of these. Then, it was performed a semi-quantitative analysis of the ß-catenin protein expression according to the technique described by Lee et al 9 , adapted for this study.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

Freitas

Silveira

et al. 2010

Acta Cir. Bras.

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Purpose: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of ß-catenin in OSCC of the tongue and its correlation with tumor metastasis. Methods: Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the ß-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++). Results: It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored "0", 33% scored + and 25% scored ++. Statistical analysis showed no diference between the studied groups. Conclusions: Based on these results, it can be concluded that the immunoexpression of ß-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue. Key words: Carcinoma, Squamous Cell. Tongue. Neoplasm Metastasis. beta Catenin. Cell Adhesion. RESUMOObjetivo: O carcinoma de células escamosas (CCE) quando presente em língua exibe aspecto mais infiltrativo, curso clínico agressivo e prognóstico desfavorável. Tais características podem associar-se com maior potencial metastático. O presente trabalho teve como meta investigar a expressão de ß-catenina em CCE de língua e sua relação com o desenvolvimento de metástases. Métodos: Foram selecionados 24 casos de CCE em língua e divididos em dois grupos: grupo metastático (n=12) e grupo sem metástase (n=12). Realizou-se uma análise semi-quantitativa da imunoexpressão da ß-catenina no fronte invasivo tumoral e sendo considerada como negativa, positiva e fortemente positiva, atribuindo-se os escores, "0", "+" e "++", respectivamente. Resultados: A expressão de ß-catenina apresentou, no grupo metastático, escore "0" em 33% dos casos, escore "+" em 50% dos casos e escore "++" em 17% dos casos; e, no grupo sem metástase, escore "0" em 42% dos casos, escore "+" em 33% dos casos e escore "++" em 25% dos casos. A análise estatística não demonstrou nenhuma diferença signficativa entre a expressão da proteína nos dois grupos. Conclusão: Diante destes resultados, concluiu-se que a expressão da ß-catenina não constitui um método eficaz, isoladamente, para predizer o potencial metastático do CCE em língua. Descritores: Carcinoma de Células Escamosas. Língua. Metástase Neoplásica. beta Catenina. Adesão Celular.

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“…There are reports that this grading is only of merit when used to evaluate deeply invasive margin (13)(14)(15)(16).…”

mentioning

confidence: 99%

<b>Histopathological and Immunohistochemical Characteristics of the Progressive Front of Ameloblastoma </b>

Yasuoka

Kato

2015

Int J Oral-Med Sci

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Ameloblastoma is a slow-developing benign odontogenic tumor, but it has relatively large number of local recurrence. Ameloblastoma was classified on the basis of the morphology that predominates in the tumor itself into plexiform type, follicular type, and other subtypes, and there have been comparative histological and clinical studies that include prognosis predictions for the different types. However, there are no conclusions regarding histological patterns and tumor activities have been reached.The purpose of the present study was to perform a detailed investigation of the progressive front of solid/multicystic type ameloblastoma in order to search for possible prognostic factors.For this study, 22 cases were chosen, in whom solid/multicystic type of a ameloblastoma.Progressive fronts of the solid/multicystic type ameloblastoma were morphologically classified into six types; plexiform, follicular, basaloid cell, sheet, trabecular and polycystic types, and immunohistochemical and morphometrical comparative studies were performed.Proliferative activity of columnar cells was highest in basaloid cell type at 1.9%. Periostin showed moderate to strong positive reaction in columnar cells of plexiform and basaloid cell types. Columnar and stellate-reticulum-like cells of basaloid cell type showed strong positive reaction for VEGF. The highest microvessel density and microvessel area using CD105 in basaloid cell type were 48.2±24.2 and 11.4±8.6%, respectively.The result of this study suggested with resection of solid/multicystic type ameloblastoma, it is important the prognosis observation to base judgment on the morphology of cells in the progressive front or in the vicinity of the resected surface.

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New malignancy grading is a better prognostic indicator than Broders' grading in oral squamous cell carcinomas

Cited by 308 publications

References 6 publications

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

<b>Histopathological and Immunohistochemical Characteristics of the Progressive Front of Ameloblastoma </b>

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