New Marine Natural Products of Microbial Origin from 2010 to 2013

Abstract

The microbial drug research started from the 20th century has become the foundation of modern drugs. Nowadays, almost 10% of all presently known compounds with bioactivities are of microbial origin. In the past decade, natural products from marine microorganisms that were regarded as a very potential resource for the drug discovery have gained great attention. This paper introduces the sources, structures and bioactivities of 895 new compounds from marine bacteria, actinomycetes and fungi reported between January 2010 and February 2013.

Mycochemistry of marine algicolous fungi

“…Among them, the halogenated (chlorinated and/or brominated) metabolites account for 6.0 %, lower than the proportions in red algae, green algae, and sediment-derived microbes and higher than those in brown algae, mangrove-, sponge-, and coral-derived microbes as well as the whole investigated organisms (Cabrita et al 2010;Gribble 2010;Wang et al 2013;Zhao et al 2013;Ji and Wang 2014). On the other hand, the sulfur-and nitrogen-containing metabolites account for 7.7 and 36.1 %, respectively.…”

“…Among the vast and diverse marine organisms, fungi have been reputed to be the prolific source of structurally unique and biologically active secondary metabolites, with more than 1000 new compounds being characterized Saleem et al 2007;Rateb and Ebel 2011;Zhu and Wang 2011;Zhao et al 2013;Blunt et al 2015). According to previous reports Rateb and Ebel 2011), over 20 % of them were produced by MAFs.…”

Enantiomeric Polyketides from the Starfish‐Derived Symbiotic Fungus Penicillium sp. GGF16‐1‐2

“…According to a survey of marine microbial natural products from 2010 to 2013, Penicillium fungi received large amounts of attention among marinederived fungi, accounting for 22 % of marine natural products of marine fungal origin. [4] Previous chemical investigations of genus Penicillium led to the isolation of certain biologically active and structurally novel secondary metabolites, such as antibacterial penicifuran A, cytotoxic brocaenols A -C, antifouling paecilin C, antioxidant JBIR-124 and anti-inflammatory penicillinolide A. [5][6][7][8][9] As a part of our ongoing investigation into bioactive novel secondary metabolites from marine- 1 These authors contribute equally as first authors.…”

Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL

“…As an essential part of marine microbes, marine-derived fungi have proven to be a major source of marine natural products due to their complex genetic background and chemodiversity [5,6]. Among them, the genus Penicillium has received great attention among all marine-derived fungi, which account for 22% of all natural products of marine fungal origin [7]. Their various secondary metabolites usually have uncommon structures and potent bioactivities that might possess substantial pharmaceutical values [8].…”