New mechanistic insights of clear cell renal cell carcinoma from integrated miRNA and mRNA expression profiling studies

Qi, Yijun; Wang, Lei; Wang, Kaizhen; Peng, Zhiqiang; Ma, Yuzhen; Zheng, Zhaoxu; Shang, Donghao; Xu, Wentao; Zheng, Junfang

doi:10.1016/j.biopha.2018.12.099

Cited by 14 publications

(12 citation statements)

References 42 publications

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“…On the one hand, a recent investigation [223] did not address variability between matched primary tumors and metastasis or changes in the genomic of RCC. On the other hand, in a few publications [224,225,226,227,228], reporting on metastatic RCC as one group, it could be proved that the microRNA profile in metastatic RCC differs from non metastatic RCC [225,229], as well as the epithelial-mesenchymal transition associated microRNA/mRNA signature [230] (The number of differently expressed miRNA in metastatic RCC was determined to be 12 [229], 14 [224], 15 [230], 20 [227], and 21 [225], respectively; 11 of these miRNAs were mentioned just in one report: miRNA 10a–p5, 21, 30c–5p, 30e, 31, 130b, 149, 199–5p, 200b, 429, 455; and 10 in two or more reports: miRNA 10b–5p, 30a–3p, 30a–5p, 139–5p, 144, 200a, 200c, 204, 223–3p, 451). In addition, the microRNA expression in distant RCC metastasis differed according to the site of metastasis in lung, bone, and brain [224].…”

Section: Discussionmentioning

confidence: 99%

Observations on Solitary Versus Multiple Isolated Pancreatic Metastases of Renal Cell Carcinoma: Another Indication of a Seed and Soil Mechanism?

Sellner¹

2019

Cancers

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Isolated pancreas metastases are a rare type of metastasis of renal cell carcinoma, characterized by the presence of pancreatic metastases, while all other organs remain unaffected. In a previous study, we determined arguments from the literature which (a) indicate a systemic–haematogenic metastasis route (uniform distribution of the metastases across the pancreas and independence of the metastatic localization in the pancreas of the side of the renal carcinoma); and (b) postulate a high impact of a seed and soil mechanism (SSM) on isolated pancreatic metastasis of renal cell carcinoma (isPM) as an explanation for exclusive pancreatic metastases, despite a systemic haematogenous tumor cell embolization. The objective of the study presented was to search for further arguments in favor of an SSM with isPM. For that purpose, the factor’s histology, grading, and singular/multiple pancreas metastases were analyzed on the basis of 814 observations published up to 2018. While histology and grading allowed for no conclusions regarding the importance of an SSM, the comparison of singular/multiple pancreas metastases produced arguments in favor of an SSM: 1. The multiple pancreas metastases observed in 38.1% prove that multiple tumor cell embolisms occur with isPM, the exclusive “maturation” of which in the pancreas requires an SSM; 2. The survival rates (SVR), which are consistent with singular and multiple pancreas metastases (despite the higher total tumor load with the latter), prove that the metastasized tumor cells are not able to survive in all other organs because of an SSM, which results in identical SVR when the pancreatic foci are treated adequately.

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Section: Discussionmentioning

confidence: 99%

Observations on Solitary Versus Multiple Isolated Pancreatic Metastases of Renal Cell Carcinoma: Another Indication of a Seed and Soil Mechanism?

Sellner¹

2019

Cancers

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“…It has been recently reported that patients with high levels of miR-16 show a poor prognosis. In contrast, miR-484, miR-497, and miR-20 have been considered as early diagnosis indicators of RCC because they are differentially expressed only in stage I tumor tissues and blood specimens [33] .…”

Section: Micrornamentioning

confidence: 99%

The emerging role of small non-coding RNA in renal cell carcinoma

Ding

Jiang

Wang

et al. 2021

Translational Oncology

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“…95 Different miRNA profiles were found in different stages of ccRCC by Qi et al, among which three miRNAs (miR-20, miR-484, miR-497) showed great discriminative ability at stage I. 96 Moreover, plasma miR-144-3p in ccRCC is significantly higher than angiolipoma and might be a potential tool for identifying benign from malignant tumors. 59 Certain studies indicated that miRNA expression patterns also have 97 Lin et al demonstrated that up-regulated miR-154 was also a biomarker for poor prognosis in ccRCC.…”

Section: Clinical Value Of Mirnasmentioning

confidence: 99%

MicroRNAs in Body Fluids: A More Promising Biomarker for Clear Cell Renal Cell Carcinoma

Shi¹,

Wang²,

Li³

et al. 2021

CMAR

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Renal cell carcinoma (RCC) is the second most common cancer of the urinary system, accounting for approximately 10-15% of kidney cancers in the world. Clear cell renal cell carcinoma (ccRCC) is the most common RCC subtype with the highest mortality. Surgical resection or puncture of tumor tissue is still an important clinical treatment and diagnosis of ccRCC, but its high recurrence rate and poor prognosis often lead to the short survival period of patients. Hence, the development of novel molecular biomarkers is of great clinical importance. miRNAs are endogenous non-coding small RNAs with a length of 19-24 nt. A growing number of studies have reported that miRNAs, as proto-oncogenes or tumor suppressor genes, play a key role in the development of ccRCC and might be effective diagnostic and prognostic biomarkers. In addition, miRNAs can also predict the efficacy of treatment drug, thus improving the accuracy of clinical medication. Furthermore, noninvasive detection of miRNAs or extracellular vesicles (EV) in body fluids has better convenience and repeatability, which shows remarkable advantages compared with tissue detection. In this review, we summarized the typical miRNAs reported in recent years and place emphasis on evaluating miRNAs in different body fluids to provide reference for the clinical diagnosis and prognosis of ccRCC in the future.

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New mechanistic insights of clear cell renal cell carcinoma from integrated miRNA and mRNA expression profiling studies

Cited by 14 publications

References 42 publications

Observations on Solitary Versus Multiple Isolated Pancreatic Metastases of Renal Cell Carcinoma: Another Indication of a Seed and Soil Mechanism?

Observations on Solitary Versus Multiple Isolated Pancreatic Metastases of Renal Cell Carcinoma: Another Indication of a Seed and Soil Mechanism?

The emerging role of small non-coding RNA in renal cell carcinoma

MicroRNAs in Body Fluids: A More Promising Biomarker for Clear Cell Renal Cell Carcinoma

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