New models involving quantum chemical parameters for assessing the chromatographic retention process

Pereira, F.J.; López, Roberto; Rodríguez-Cordero, A.; Robles, L. C.; Suárez, Dimas; Aller, A. J.

doi:10.1016/j.microc.2021.106693

Cited by 1 publication

(1 citation statement)

References 47 publications

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“…Further, the PCT molecule can exist in solution as four conformers with different stability, potentially changing with pH. The planar-geometry trans-conformers (E or Z), more easily solvated than the nonplanar-geometry cis-conformers (E or Z), present an intramolecular bond between a benzene hydrogen atom and the carbonyl oxygen, introducing stabilisation in the trans-conformer planarity [55,56]. The intramolecular bonding in trans-conformers also adds stiffness to these structures, making their folding even more difficult but facilitating solvation.…”

Section: Effect Of Scan Ratementioning

confidence: 99%

Electrochemical Kinetics and Detection of Paracetamol by Stevensite-Modified Carbon Paste Electrode in Biological Fluids and Pharmaceutical Formulations

Gharous,

Bounab,

Pereira

et al. 2023

IJMS

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Paracetamol (PCT), or acetaminophen, is an important drug used worldwide for various clinical purposes. However, the excessive or indiscriminate use of PCT can provoke liver and kidney dysfunction; hence, it is essential to determine the amount of this target in biological samples. In this work, we develop a quick, simple, and sensitive voltammetric method using chemically modified electrodes to determine PCT in complex matrices, including human serum and commercial solid formulations. We modify the carbon paste electrode with stevensite monoclinic clay mineral (Stv-CPE), using cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy to characterise and detect PCT. The kinetics study provides a better electrochemical characterisation of the electrode behaviour, finding the detection and quantitation limits of 0.2 μM and 0.5 μM under favourable conditions. Further, the best linear working concentration range is 0.6–100 μM for PCT, applying the proposed method to the quantitative determination of PCT content in reference tablet formulations and biological samples for validation.

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Section: Effect Of Scan Ratementioning

confidence: 99%