New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells

Ding, Lei; Zhao, Feng; Chen, Lixia; Jiang, Zhihu; Liu, Yue; Li, Zhuomin; Qiu, Feng; Yao, Xin‐Sheng

doi:10.1016/j.bmcl.2012.09.034

Cited by 34 publications

(21 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As for the phenols, the aglycon with m/z 293.1748 was confirmed to be gingerol in both methanol extracts from maca leaves and roots. The unique phenols in the methanol extract from maca leaves were m/z 692.2200 and 495.1482 identified as kuwanon G and oxypaenoniflorin, respectively (Ding et al, 2012). The m/z 256.1748 of tolmetin was only found in the methanol extract from maca roots.…”

Section: Lc-q-tofmentioning

confidence: 95%

Physicochemical and antioxidant properties of methanol extract from Maca (Lepidium meyenii Walp.) leaves and roots

Lee

Chang

2019

Food Sci. Technol

View full text Add to dashboard Cite

The dried maca leaves and roots were collected from High Dongbang Agricultural Products Cooperative (Kangwondo, Chunchen, Korea). HPLC-grade acetonitrile, water and formic acid were purchased from Sigma Chemical Co. (St. Louis, MD, USA). All other chemical reagents were of analytical grade. 2.2 Chemical and mineral composition of maca leaves and roots The chemical composition of dried maca leaves and roots, including moisture, ash, protein, and fat contents, was determined according to ADAC methods (ADAC, 2005

show abstract

Section: Lc-q-tofmentioning

confidence: 95%

Physicochemical and antioxidant properties of methanol extract from Maca (Lepidium meyenii Walp.) leaves and roots

Lee

Chang

2019

Food Sci. Technol

View full text Add to dashboard Cite

show abstract

“…Found in P. lactiflora, the monoterpene glycoside oxypaeoniflorin and the lesser abundant paeoniflorigenone show NO reduction in lipopolysaccharide-activated murine microglial cell lines (N9) (Duan et al, 2009;Ding et al, 2012). Another of its abundant monoterpene glycosides is benzoylpaeoniflorin, which is indicated to have inhibition against prostaglandin synthesizing cyclooxygenase (COX) 1 and 2 (Zhu and Fang, 2014).…”

mentioning

confidence: 99%

A Pharmacological Review of Bioactive Constituents ofPaeonia lactifloraPallas andPaeonia veitchiiLynch

et al. 2016

View full text Add to dashboard Cite

The roots of two peony species, Paeonia lactiflora Pallas and Paeonia veitchii Lynch are routinely referred to as either chishao () or baishao (). This paper reviews the botanical origins and traditional medicinal usage of each species, as well as pharmacological like activity of their constituents. A search of herbal pharmacological encyclopaedia, PubChem and PubMed databases identified their known constituents. The biological data for these constituents were evaluated and classified according to pharmacological-like activity, with emphasis on compounds of greatest concentration and bioavailability. It was found that P. lactiflora and P. veitchii have some common compounds; however, their phytochemical bioavailability varies. Furthermore, a larger number of compounds have been identified in P. lactiflora. These have greater potential for antiinflammatory, antiviral, antibacterial and antioxidant therapeutic activity compared with P. veitchii. However, evidence indicates both species are similarly indicated for antiviral and glycaemic activity. Major compounds of each are classified as flavonoids, hydrolysable tannins (polyphenols) and monoterpene glycosides. The evidence suggests both species, when administered in entire botanical form, have an excellent safety profile; however, constituent toxicity risk evidence is limited, requiring further investigation. Although experiments show many compounds have biological activity, further investigation of their therapeutic potential is needed. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

“…To our current best knowledge, 119 compounds have been isolated and structurally identified from CM, which can be assigned to seven classes: monoterpenes, monoterpene glycosides, flavonoids, tannins, triterpenoids, phenols and others [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Monoterpene glycosides and phenols are predominant constituents in CM ( Figure 2 and Table S1 ).…”

Section: Chemistry Of CMmentioning

confidence: 99%

Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeonia suffruticosa Andrew): A Systematic Review

Wang

Peng

et al. 2017

Molecules

View full text Add to dashboard Cite

Cortex Moutan (CM), a well-known traditional Chinese medicine, is commonly used for treating various diseases in China and other eastern Asian countries. Recorded in Pharmacopeias of several countries, CM is now drawing increasing attention and under extensive studies in various fields. Phytochemical studies indicate that CM contains many valuable secondary metabolites, such as monoterpene glycosides and phenols. Ample evidence from pharmacological researches suggest that CM has a wide spectrum of activities, such as anti-inflammatory, anti-oxidant, anti-tumor, anti-diabetic, cardiovascular protective, neuroprotective, hepatoprotective effects. Moreover, various analytical methods were established for the quality evaluation and safety control of CM. This review synopsizes updated information concerning the origins, phytochemistry, pharmacology, analytical method and safety of CM, aiming to provide favorable references for modern CM research and application. In conclusion, continuing pharmacological investigations concerning CM should be conducted to unravel its pharmacological mechanisms. Further researches are necessary to obtain comprehensive and applicable analytical approach for quality evaluation and establish harmonized criteria of CM.

show abstract

New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells

Cited by 34 publications

References 14 publications

Physicochemical and antioxidant properties of methanol extract from Maca (Lepidium meyenii Walp.) leaves and roots

Physicochemical and antioxidant properties of methanol extract from Maca (Lepidium meyenii Walp.) leaves and roots

A Pharmacological Review of Bioactive Constituents ofPaeonia lactifloraPallas andPaeonia veitchiiLynch

Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeonia suffruticosa Andrew): A Systematic Review

Contact Info

Product

Resources

About