New multidrug resistance modulators from atractylodis lanceae rhizoma

Murakami, Nobutoshi; Iwata, Etsuko; Tamura, Shinji; Akiyama, Shin Ichi; Kobayashi, Mariko

doi:10.1016/s0960-894x(00)00536-9

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…Peaks 57 and 58 were isomers that showed the same quasimolecular ion at m/z 701 [M + Na] + ; they were both identified as atractysucrose III [23]. Peaks 68, 69, and 72 were also isomers labeled as atractysucrose I [23]. Comparison of the MS and MS/MS data with the reported literature data [24] identified peak 60 as atractylenolide I.…”

Section: Resultsmentioning

confidence: 99%

“…Comparison of the retention times and MS and MS/MS data with the reference standard compounds identified peak 48 as obakulactone [22]. Peaks 57 and 58 were isomers that showed the same quasimolecular ion at m/z 701 [M + Na] + ; they were both identified as atractysucrose III [23]. Peaks 68, 69, and 72 were also isomers labeled as atractysucrose I [23].…”

Section: Resultsmentioning

confidence: 99%

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Identification of the Chemical Constituents in Simiao Wan and Rat Plasma after Oral Administration by GC‐MS and LC‐MS

Fan

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Simiao Wan (SMW), an important multiherbal formula used in traditional Chinese medicine, is extensively used to treat rheumatoid arthritis. However, the knowledge of the bioactive components of SMW remains unclear. Thus, gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–mass spectrometry (LC-MS) were used to analyze the chemical constituents of volatile and nonvolatile extracts of SMW, as well as its absorbed components in rat plasma after oral SMW administration. Identification of several compounds was enabled by comparison of retention times, MS spectra, and MS/MS spectral data with the standard substance and reference materials reported in the literature. In the volatile extracts, GC-MS identified 26 compounds in vitro, three of which observed in blood by GC-MS. In the nonvolatile extracts, LC-MS identified 49 compounds in SMW; 18 compounds containing 7 prototype compounds, 5 metabolites, and 6 unknown compounds were absorbed by blood. The proposed GC-MS and LC-MS method was appropriate not only for the rapid screening and identification of multiple components of an SMW extract but also for screening its bioactive constituents in vivo. The proposed method could be a promising tool for the quality control of other Chinese herbal medicines.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Identification of the Chemical Constituents in Simiao Wan and Rat Plasma after Oral Administration by GC‐MS and LC‐MS

Fan

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…The structures of respective compounds were identified by the detailed analysis of spectroscopic data and comparison of the data with those reported [6,7].…”

Section: Methodsmentioning

confidence: 99%

Structure Elucidation of Acylsucrose Derivatives from Atractylodes lanceae Rhizome and Atractylodes Rhizome

Tanaka

Ina²

2009

Natural Product Communications

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The mass chromatographic fingerprints of the water extracts of Atractylodes rhizome and Atractylodes lancea rhizome were analyzed by LC-MS. Three new acylsucrose derivatives [2,6,3′,6′-tetra(3-methylbutanoyl)sucrose (1), 2,4,3′,6′-tetra(3-methylbutanoyl)sucrose (2), and a mixture of 3′,4′,6′-tris(3-methylbutanoyl)-1′-(2-methylbutanoyl)sucrose and 1′,3′,4′,6′-tetra(3-methylbutanoyl)sucrose (6)), along with three known acylsucroses (2,6,3′,4′-tetra(3-methylbutanoyl)sucrose (3), 2,4,3′,4′-tetra(3-methylbutanoyl)sucrose (4) and a mixture of 2,3′,6′-tris(3-methylbutanoyl)-1′-(2-methylbutanoyl)sucrose and 2,1′,3′,6′-tetra(3-methylbutanoyl)sucrose (5)] were isolated as the marker compounds of Atractylodes rhizome and Atractylodes lancea rhizome. The structures of the compounds were elucidated by MS/MS analyses and NMR experiments.

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“…Lately, peruvioses C to E were described in P. peruviana fruits . Many species in the family Solanaceae, such as tobacco, tomato, potato, petunia, and other species from the genus Physalis , are known to produce aliphatic esters of sucrose and glucose as a defense against insects. − This class of compounds exhibits biological properties such as insecticidal, anti-inflammatory, multidrug resistance modulatory, plant growth inhibitory, and antibacterial activities. ,− Hitherto, no studies have reported the effects of natural aliphatic SEs on skin. Therefore, as part of our continuing efforts to develop new natural active ingredients, an extract of P. peruviana calyces was evaluated for its selective skin antiaging activity in an aged normal human dermal fibroblast (NHDF) cell-based assay.…”

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confidence: 99%

Upregulation of Skin-Aging Biomarkers in Aged NHDF Cells by a Sucrose Ester Extract from the Agroindustrial Waste of Physalis peruviana Calyces

Cicchetti¹,

Duroure²,

Borgne³

et al. 2018

J. Nat. Prod.

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As part of a search for new sustainable plant sources of valuable compounds, the EtOAc extract of the discarded calyces of Physalis peruviana fruit was selected for its significant antiaging activity. Eight new sucrose esters (SEs), named peruvioses F-M (1-8), along with three known SEs, peruvioses A (9), peruviose B (10), and nicandrose D (11), were isolated. Their structures were elucidated by comprehensive analyses of their NMR and MS data. A global fragmentation pattern of these SEs was established from their MS data. The SE extract (SEE) at a concentration of 0.5 mg L upregulated multiple skin-aging biomarkers, namely, collagen I, elastin, and fibrillin-1, in aged normal human dermal fibroblast cells. A 36% increase in collagen I was observed. The elastin and fibrillin-1 contents were fully recovered, and an increase of at least 10% in the production of elastin was observed.

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New multidrug resistance modulators from atractylodis lanceae rhizoma

Cited by 10 publications

References 7 publications

Identification of the Chemical Constituents in Simiao Wan and Rat Plasma after Oral Administration by GC‐MS and LC‐MS

Identification of the Chemical Constituents in Simiao Wan and Rat Plasma after Oral Administration by GC‐MS and LC‐MS

Structure Elucidation of Acylsucrose Derivatives from Atractylodes lanceae Rhizome and Atractylodes Rhizome

Upregulation of Skin-Aging Biomarkers in Aged NHDF Cells by a Sucrose Ester Extract from the Agroindustrial Waste of Physalis peruviana Calyces

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