New Natural Taxane Diterpenoids fromTaxus Species since 1999

Exploring the Potential of Natural Products in Cancer Treatment

“…The high likelihood that a single compound may be present in several taxa of the same genus, and thus be responsible for the bioactivity of these, decreases the possibilities of finding a new lead compound. About 400 taxane-type diterpenoids have been isolated from various Taxus plants so far, and some of them possess interesting anticancer activities (Shi and Kiyota, 2005;Kingston and Newman, 2007). Furthermore, this screening introduced a solution to the problem of the supply of taxol.…”

Tri‐ and Bicyclic Taxoids from the Taiwanese Yew Taxus sumatrana

“…The (5)), which exhibited a COSY correlation with HÀC(6) and HMBC correlations with C(7), C(3), and C(20). On the other hand, the NOESY spectrum of 3 showed cross peaks between HÀC(2) and HÀC(1) and Me(16), between Me(17) and HÀC (1), and between Me(16) and HÀC(13), as observed in 2. HÀC (5) showed an interaction with the olefinic HÀC(3) in the NOESY spectrum (Fig.…”

“…-Plants from the genus Taxus are a rich source of biologically active diterpenoids belonging to the unique taxane class [1]. Taxoids are highly oxygenated and esterified diterpenes, mostly containing a 6/8/6-membered skeleton as in paclitaxel, and have been isolated from different species of yew trees (family Taxaceae).…”

Taxusecone, a Novel Taxane with an Unprecedented 11,12-Secotaxane Skeleton, fromTaxus cuspidataNeedles

“…Its unique mechanism of action, limited availability and relative lipophilicity had spurred world-wide interest in various areas, and extensive chemical studies have let to the isolation of more than 550 taxanes. [2][3][4][5] Our continuing search for bioactive taxanes from the needles of this Japanese yew, Taxus cuspidata, * resulted in the isolation of a taxane with a novel skeleton, named taxusecone. (Fig.…”