New Onoceranoid Triterpene Constituents from Lansium domesticum

Abstract

Three new natural onoceranoid triterpenes, lansionic acid (1), 3beta-hydroxyonocera-8(26),14-dien-21-one (2), and 21alpha-hydroxyonocera-8(26),14-dien-3-one (3), were isolated from the fruit peel of Lansium domesticum together with two known triterpenoids (4 and 5), and their structures were elucidated from spectral data. These triterpenoids exhibited mild toxicity against brine shrimp (Artemia salina).

SCREENING OF ANTIOXIDANTS, ANTI-AGING AND TYROSINASE INHIBITORY ACTIVITIES OF ETHANOLIC AND ETHYL ACETATE EXTRACTS OF FRUIT FLESH AND FRUIT PEEL LANGSAT (Lansium domesticum Corr) IN VITRO

“…Hal yang sama diperoleh pada profil KLT dari ekstrak etanol kulit langsat (KLE) dan ekstrak etil asetat kulit langsat (KLEA) masing-masing adanya spot yang menunjukkan golongan senyawa flavonoid dan steroid/terpenoid. Hal ini sesuai dengan beberapa literatur yang menjelaskan bahwa L.domesticum memiliki kandungan senyawa flavonoid dan steroid/terpenoid (Klungsupya et al, 2015;Nishizawa et al, 1982Nishizawa et al, , 1989Tanaka et al, 2002).…”

Anti-proliferative and matrix metalloproteinase-2 inhibition of Longkong (Lansium domesticum) extracts on human mouth epidermal carcinoma

“…Most compounds containing in the seed of Longkong are tetranorterpenoids, including domesticulide A-E, with 11 known triterpenoids. Six classes of limonoids have been isolated from the seed extracts of L. domesticum, including andirobin derivates, methyl angolensates, mexicanolides, azadiradiones, onoceranoids, and dukunolides (Tanaka et al, 2002). Sassa et al have demonstrated the inhibitory effect of the dienone-phenolic triterpene on lipid peroxidation in rat liver mitochondrial membranes induced by ADP and Fe 2þ (Sassa et al, 1990).…”

Wrightiamines A and B, Two New Cytotoxic Pregnane Alkaloids from Wrightia javanica

“…(Apocynaceae) is a small tree widely distributed over the northern Malayan peninsula and other south Asian areas, and its milky lotion has been used as a folk medicine. 1) During our search for bioactive natural products from tropical plants, 2) we investigated the chemical constituents of leaves of W. javanica collected in Thailand.…”

“…Here we describe the isolation and structure elucidation of two new pregnane alkaloids, wrightiamines A (1) and B (2), and preparation of compound 2 to establish the C-20 configuration. 1 exhibited cytotoxic activity against vincristine-(VCR)-resistant murine leukemia P388 cells, while the cytotoxicity of 2 was weak.…”

“…7) Jones oxidation of 5 and 6 afforded 20S-and 20R-amino-5a-pregnan-3-one (2, 7), respectively, and wrightiamine B proved to be identical to the 20S-isomer (2) on the basis of the comparison of TLC and 1 H-NMR spectral data. Thus the structure of wrightiamine B was established to be 20S-amino-5a-pregnan-3-one (2).…”