New-Onset Acute Kidney Disease Post COVID-19 Vaccination

Li, Yebei; Rao, Meiying; Xu, Gaosi

doi:10.3390/vaccines10050742

Cited by 15 publications

(16 citation statements)

References 83 publications

(116 reference statements)

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“…In contrast, the progression of minimal change disease takes a certain amount of time, suggesting the role of cell-mediated immunity [ 9 ]. The mechanism underlying podocyte damage after COVID-19 vaccination is hypothesized to involve the expression of permeability factors, such as cytokines and autoantibodies, by stimulating antigen-presenting cells, B cells, and activating T cells, which leads to loss of foot processes and disruption of the glomerular permeation barrier [ 10 ]. In addition, several COVID-19 infection-related nephritis cases have been reported, and COVID-19 infection is believed to directly cause podocyte damage [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Association between COVID-19 vaccination and relapse of glomerulonephritis

et al. 2022

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Background Vaccines for coronavirus disease 2019 (COVID-19) have been developed and are recommended for patients with chronic kidney disease; however, it has been reported that glomerulonephritis worsens after vaccination. We aimed to elucidate the incidence and association between COVID-19 vaccination and glomerulonephritis relapse. Methods We investigated the onset of renal events and adverse reactions after COVID-19 vaccination in 111 patients diagnosed with glomerulonephritis. Renal events were defined as worsening hematuria, increased proteinuria, and an increased creatine level over 1.5-fold from baseline. Results Patients were 57 ± 18 years old (55.9% female) and had an estimated glomerular filtration rate of 57.0 ± 25.0 ml/min/1.73 m 2 . A pathological diagnosis of IgA nephropathy was confirmed in 55.0%, minimal change disease in 22.5%, and membranous nephropathy in 10.8% of the patients. The BNT162b2 (Pfizer) and mRNA-1273 (Moderna) vaccines were administered in 88.2% and 11.7% of the cases, respectively. Renal events were observed in 22.5% of patients, 10.8% had increased proteinuria, 12.6% had worsening hematuria, and 1.8% received additional immunosuppressive treatment. Only 0.9% required temporary hemodialysis from exacerbation of renal dysfunction. Renal events were higher in younger patients ( P = 0.02), being highest in those with IgA nephropathy, but there was no difference in the incidence between pathological diagnoses. There was a significantly higher incidence of renal events in patients with fever ( P = 0.02). Conclusions COVID-19 vaccination and glomerulonephritis relapse may be related, but further research is needed. Supplementary Information The online version contains supplementary material available at 10.1007/s10157-022-02299-6.

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Section: Discussionmentioning

confidence: 99%

Association between COVID-19 vaccination and relapse of glomerulonephritis

et al. 2022

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“…In addition to causing new onset or worsening pre-existing diabetes, diabetes and hyperglycemia are linked to a worse prognosis in COVID-19 patients. A small fraction of individuals diagnosed with COVID-19, many of whom did not have a previous history of diabetes mellitus (DM), have been found to experience extreme hyperglycemia and acute hyperglycemic emergencies such as diabetic ketoacidosis (DKA) based on case reports [ 11 , 12 , 13 , 14 , 31 ], and/or hyperosmolar hyperglycemic syndrome (HHS), with 91 cases of DKA and 19 cases of DKA/HHS reported in clinical trials [ 11 , 12 , 13 , 14 , 31 ]. The co-existence of COVD-19 and diabetes is a two-way street.…”

Section: Covid-19 Vaccines and Premature Diabetesmentioning

confidence: 99%

“…The majority of NCDs associated with COVID-19 vaccines account for: (1) CVDs including hypertension, myocarditis, infarctions, thromboembolic events, and arrhythmia [ 3 , 8 , 9 , 10 ]; (2) premature obesity and diabetes [ 11 , 12 , 13 , 14 , 15 ]; (3) acute kidney disorders (AKDs) [ 16 ]; and (4) premature neurodegeneration and mental disorders [ 17 , 18 , 19 , 20 , 21 ], and autoimmune spectrum disorders including vaccine-induced immune thrombotic thrombocytopenia (VITT) and leukocytoclastic vasculitis [ 22 , 23 ]. Other systemic adverse reactions such as fever, headache, widespread fatigue, chills, arthralgia, muscular pain, and nausea [ 24 ] are transient and not discussed in this review.…”

Section: Introductionmentioning

confidence: 99%

Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

et al. 2023

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According to the WHO, as of January 2023, more than 850 million cases and over 6.6 million deaths from COVID-19 have been reported worldwide. Currently, the death rate has been reduced due to the decreased pathogenicity of new SARS-CoV-2 variants, but the major factor in the reduced death rates is the administration of more than 12.8 billion vaccine doses globally. While the COVID-19 vaccines are saving lives, serious side effects have been reported after vaccinations for several premature non-communicable diseases (NCDs). However, the reported adverse events are low in number. The scientific community must investigate the entire spectrum of COVID-19-vaccine-induced complications so that necessary safety measures can be taken, and current vaccines can be re-engineered to avoid or minimize their side effects. We describe in depth severe adverse events for premature metabolic, mental, and neurological disorders; cardiovascular, renal, and autoimmune diseases, and reproductive health issues detected after COVID-19 vaccinations and whether these are causal or incidental. In any case, it has become clear that the benefits of vaccinations outweigh the risks by a large margin. However, pre-existing conditions in vaccinated individuals need to be taken into account in the prevention and treatment of adverse events.

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“…However, the incidence of minimal change disease is higher in the adolescent population in unvaccinated individuals. 149 The striking similarity in kidney pathology between human immunodeficiency virus-associated nephropathy. The identification of the type of kidney injury in patients depends on renal pathological examination, except that some patients have positive antineutrophil cytoplasmic antibody.…”

Section: Tubular Epithelial Cellsmentioning

confidence: 99%

“…The incidence of minimal change disease is slightly higher in COVID‐19 patients and is more common in the adolescent population. However, the incidence of minimal change disease is higher in the adolescent population in unvaccinated individuals 149 . The striking similarity in kidney pathology between human immunodeficiency virus‐associated nephropathy.…”

Section: Pathological Changes Related To Covid‐19‐related Kidney Injurymentioning

confidence: 99%

Pathogenesis and histological changes of nephropathy associated with COVID‐19

Deng

et al. 2022

Journal of Medical Virology

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Coronavirus disease 2019 (COVID‐19) can cause damage to multiple organ, not only to the lungs, but also to the kidneys. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can cause acute and chronic kidney disease through direct viral infection, indirect injury, and vaccination‐related injury. Like lung injury, kidney injury is also an important aspect affecting the severity and prognosis of SARS‐CoV‐2. This article summarizes the pathogenesis, pathological manifestations, and clinical features of SARS‐CoV‐2 direct or indirect renal injury. Including direct injury, indirect injury, special comorbidities (receiving kidney transplantation and chronic kidney disease), and vaccine‐related renal injury, and exploring the possible therapeutic effect of anti‐SARS‐CoV‐2 therapy on renal injury. The purpose is to provide reference for understanding COVID‐19‐related renal injury, guiding clinical and pathological diagnosis and treatment, and evaluating prognosis.

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New-Onset Acute Kidney Disease Post COVID-19 Vaccination

Cited by 15 publications

References 83 publications

Association between COVID-19 vaccination and relapse of glomerulonephritis

Association between COVID-19 vaccination and relapse of glomerulonephritis

Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

Pathogenesis and histological changes of nephropathy associated with COVID‐19

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