New-onset asthma and the effect of environment and occupation among farming and nonfarming rural subjects

Omland, Øyvind; Hjort, Charlotte; Miller, Martin; Sigsgaard, Torben

doi:10.1016/j.jaci.2011.06.006

Cited by 50 publications

(44 citation statements)

References 32 publications

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“…Of interest, some aspects in early life appear to protect against the development of asthma. In children, contact with livestock and being born and raised on a farm reduces the risk of asthma in adulthood [28][29][30]. Similar to viruses, it is unknown whether the bacterial colonisation acts as the environmental trigger in genetically predisposed persons or whether this colonisation is merely a marker of the underlying genetic asthmatic constitution.…”

Section: Childhood-onset Asthmamentioning

confidence: 99%

Adult-onset asthma: is it really different?

Nijs¹,

Venekamp²,

Bel³

2013

Eur Respir Rev

251

205

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Asthma that starts in adulthood differs from childhood-onset asthma in that it is often non-atopic, more severe and associated with a faster decline in lung function.Understanding of the underlying mechanism of adult-onset asthma and identification of specific phenotypes may further our understanding of pathophysiology and treatment response, leading to better targeting of both existing and new approaches for personalised management. Pivotal studies in past years have led to sustained progress in many areas, ranging from risk factors for development, identification of different phenotypes, and introduction of new therapies.This review highlights and discusses literature on adult-onset asthma, with special focus on the differences from childhood-onset asthma, risk factors for development, phenotypes of adultonset asthma and new approaches for personalised management.

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Section: Childhood-onset Asthmamentioning

confidence: 99%

Adult-onset asthma: is it really different?

Nijs¹,

Venekamp²,

Bel³

2013

Eur Respir Rev

251

205

View full text Add to dashboard Cite

show abstract

“…The frequent use of bleach (hypochlorite), ammonia, and degreasing sprays has been consistently associated with asthma among workers exposed to cleaning agents (42,44,48), although the precise chemical exposures and the mechanisms responsible for the increased incidence of asthma have not been clarified since cleaning materials typically contain a wide variety of ingredients, some of which are respiratory irritants, while others are potential airway sensitizers (Table 6). Other occupations associated with increased risk of asthma that cannot be readily or completely explained on the basis of a clear sensitizing exposure are presented in Table 6 (47,(49)(50)(51)(52)(53)(54)(55)(56).…”

Section: Epidemiological Evidence For Irritant-induced Asthmamentioning

confidence: 99%

EAACI position paper: irritant‐induced asthma

Vandenplas

Wiszniewska

Raulf

et al. 2014

Allergy

130

108

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The term irritant-induced (occupational) asthma (IIA) has been used to denote various clinical forms of asthma related to irritant exposure at work. The causal relationship between irritant exposure(s) and the development of asthma can be substantiated by the temporal association between the onset of asthma symptoms and a single or multiple high-level exposure(s) to irritants, whereas this relationship can only be inferred from epidemiological data for workers chronically exposed to moderate levels of irritants. Accordingly, the following clinical phenotypes should be distinguished within the wide spectrum of irritant-related asthma: (i) definite IIA, that is acute-onset IIA characterized by the rapid onset of asthma within a few hours after a single exposure to very high levels of irritant substances; (ii) probable IIA, that is asthma that develops in workers with multiple symptomatic high-level exposures to irritants; and (iii) possible IIA, that is asthma occurring with a delayed-onset after chronic exposure to moderate levels of irritants. This document prepared by a panel of experts summarizes our current knowledge on the diagnostic approach, epidemiology, pathophysiology, and management of the various phenotypes of IIA.Abbreviations IIA, irritant-induced asthma; NSBH, nonspecific bronchial hyperresponsiveness; OA, occupational asthma; RADS, reactive airways dysfunction syndrome; TRP, transient receptor potential.

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“…Several epidemiological studies have shown a clear link between early exposure to microorganisms and the incidence of asthma (Riedler et al, 2001;Ege et al, 2011;Omland et al, 2011), referring to this phenomenon as "the hygiene hypothesis". The increasing use of antibiotic treatment (Droste et al, 2000;Verhulst et al, 2008) as well as the change in lifestyle in westernized countries (Matricardi, 2001), especially including diet (Chatzi et al, 2007;Willers et al, 2011), can lead to alterations in the microbial composition and such conditions are strongly linked to a higher risk of asthma development (Bottcher et al, 2000).…”

Section: Asthmamentioning

confidence: 99%