New‐Onset Ichthyosis and Diabetes in a 14‐Year‐Old

Abstract

Diabetes has not been linked to acquired ichthyosis or ichthyosis vulgaris. We report a newly diagnosed diabetic 14-year-old girl with bilateral tibial and sacral ichthyosiform plaques and a hemoglobin A1c of 20.1%. The patient had no personal or family history of atopy or ichthyosis and lacked keratosis pilaris or hyperlinear palms. A biopsy specimen of an ichthyosiform plaque showed compact lamellar orthohyperkeratosis and hypogranulosis, histopathology consistent with either ichthyosis vulgaris or acquired ichthyosis. We speculate that our patient's new-onset diabetes induced acquired ichthyosis.

Spectrum of cutaneous manifestations of type 1 diabetes mellitus in 500 south Asian patients

“…As a group, CAII comprising lipohypertrophy, PIH, lipoatrophy, acanthosis nigricans, and other infrequent lesions such as urticarial reactions, folliculitis and keloid were the most common findings, contrary to previous studies, in which ichthyosiform skin changes was the most frequent finding. It could be due to reporting of asteototic eczema as acquired ichthyosis . Raile et al .…”

“…It could be due to reporting of asteototic eczema as acquired ichthyosis. 7 Raile et al 8 reported lipohypertrophy in 43Á7% of 112 patients with type 1 DM. Hajheydari et al 9 documented a higher frequency of lipohypertrophy in patients with type 1 DM compared with type 2 DM (37Á5% vs. 6Á7%).…”

The combination of two monogenic diseases, congenital lamellar ichthyosis and type 2 MODY diabetes mellitus

“…Имеются две публикации, в которых описывается сочетание СД 1-го типа и приобретенного ихтиоза, а также сочетание ихтио-зиформного дерматоза с СД 2-го типа [16,17]. В первой публикации приведено описание 14-летней девушки афроамериканского происхождения, стра-дающей СД 1-го типа в течение 6 мес.…”

Recurrent Congenital Ichthyosis in Newborn: A Case Report

“…Diabetes has not been definitively linked to acquired ichthyosis or ichthyosis vulgaris; however, there are case reports associating new onset ichthyosis with diabetes. 6 Fetal skin biopsy at approximately 19 weeks may provide an early diagnosis of certain forms of ichthyosis (i.e. Harlequin type, which is extremely severe and usually fatal.…”