New organometallic ruthenium(ii) complexes containing chelidonic acid (4-oxo-4H-pyran-2,6-dicarboxylic acid): synthesis, structure and in vitro biological activity

Biophysical and In Silico Studies of the Interaction between the Anti-Viral Agents Acyclovir and Penciclovir, and Human Serum Albumin

“…A wide range of binding information (e.g., strength and mechanism of binding, thermodynamic characteristics of the protein) can be obtained through these quenching studies [ 17 , 18 ]. In the same context, examining serum albumin’s binding to the different drugs can offer a thorough understanding of the drug journey inside the body [ 21 , 22 ]. Quenching of the fluorescence intensity can be due to either dynamic and static interaction, or both.…”

Electrochemical Characteristics of 4‐oxo‐4H‐pyran‐dicarboxylic Acid (Chelidonic Acid) and some of its Metal Complexes

“…for pH 1–6). This means that for higher pH values the reduction is energy less favourable process due to negative charges of both carboxylic groups of the chelidonic acid molecule (p Ka of both carboxylic groups is ∼2.4 ). In other words, deprotonation hampers reduction reaction compared to the same process in acidic media.…”

“…The “pre”‐peak (0) corresponds to capacitive current as a result of charging the electrical double layer at the electrode surface at pH≤2. Furthermore, the “post”‐peak (2) could be identified as an totally irreversible reduction of the protons of ‐COOH groups at the electrode surface, since this peak is only observed in solutions of pH≤2 (p Ka ≈2.4 ). Thus, the main peak (1) could be assigned to a redox reaction of the oxo‐group in chelH 2 molecule.…”

“…Thus, due to its excellent coordination properties, in the past few decades, various metal complexes of chelidonic acid were synthesized and reported. They are structurally characterised and for some of them a biological activity was investigated too , e.g . ruthenium(II) metalo organic compound containing chelidonate ligand is more toxic than its parent ligand against some microorganisms and possesses excellent free radical scavenging properties .…”

“…They are structurally characterised and for some of them a biological activity was investigated too , e.g . ruthenium(II) metalo organic compound containing chelidonate ligand is more toxic than its parent ligand against some microorganisms and possesses excellent free radical scavenging properties . However, to the best of our knowledge electrochemical/redox properties of chelidonic acid and its in situ coordination potential toward metal ions have never been investigated.…”