Ruthenium Complexes as Antifungal Agents

Complexes of Ruthenium(II) as Promising Dual-Active Agents against Cancer and Viral Infections

“…Bresciani et al (2023) [146] presented a study regarding the antitumor potential of several dinuclear Ru biscyclopentadienyl carbonyl complexes (23)(24)(25)(26) against A549 (lung), SW480 (colon), and A2780 and A2780cis (ovarian) cancer cell lines, as well as the nontumoral HEK-293 cell line. Cisplatin was used as the standard (IC 50 = 43 ± 3 µM, 35 ± 2 µM, 8.3 ± 1.4 µM, and 30 ± 3 µM, respectively, against cancer cell lines).…”

“…Ru complexes represent an important class of metallo-organic compounds with numerous applications, and they are currently used in the fields of catalysis [20][21][22][23], including homogeneous, heterogeneous, and photocatalysis [24]. Moreover, numerous biological activities, such as antifungal [25], antibacterial [26], and anticarcinogenic [27][28][29][30][31][32], have been described for the complexes of Ru, as well as their uses in neurodegenerative diseases [33]. Several complexes with Ru(II) have been reported, including those with benzoic acid and their analogues [34], naphthoquinones, flavonoids, curcumins [35], N-heterocyclic carbenes (NHCs) [36], polypyridyl [37], phenanthroline [38], thiazole [39], Schiff bases [40][41][42][43], and half-sandwiched arene complexes [44].…”

Synthesis, crystallographic structure, theoretical analysis, molecular docking studies, electronic properties and biological activity evaluation of ruthenium-complex bearing N-heterocyclic carbene ligand

“…18 In addition, ruthenium complexes have been reported to have many other biological activities, 18 such as antioxidant, anti-inflammatory 19 and antibacterial. 3,20,21 Recent studies have also involved the use of ruthenium complexes as antiviral drugs for the treatment of COVID-19. 22 Ruthenium complexes include complexes with Schiff bases, [23][24][25] phosphine, 26 carbazole, 27 N-heterocyclic carbene (NHC), cyclic ruthenium, and half-sandwich compounds.…”