New pathway of icariin-induced MSC osteogenesis: transcriptional activation of TAZ/Runx2 by PI3K/Akt

Abstract

Open Life Sci. 2017; 12: 228-236 further mediated the transcriptional activation of the TAZ/ Runx2 pathway to induce osteogenic differentiation of MSCs.

How to calculate the age at formation of Harris lines? A step-by-step review of current methods and a proposal for modifications to Byers’ formulas

“…Also, the histological model of formation of HLs could be improved-there is no unanimity whether the HLs are rather Bgrowth arrest^ (Scott and Hoppa 2015) or Bgrowth recovery lines^ (Sajko et al 2011). Current biochemical models assume the involvement of GH and IGF-1 (Alfonso-Durruty 2011); however, bone growth and mineralization may be connected also with other proteins and pathways, such as TAZ/Runx2 and PI3K/Akt (Alkagiet and Tziomalos 2017;Zhang et al 2017), or could involve miRNA (Han et al 2017) and long non-coding RNA (Xi et al 2018). Better understanding of the biochemical base of HL formation could improve the interpretation of results involving these lines.…”