New Perspective Enteric-Coated Tablet Dosage Form for Oral Administration of Ceftriaxone: In Vitro and In Vivo Assessments

Maghrabia, Amir E; Boughdady, Mariza; Meshali, M. M.

doi:10.1208/s12249-019-1512-y

Cited by 15 publications

(16 citation statements)

References 34 publications

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“…All bands appeared very close to the reported data. 25 Characteristic bands of ceftriaxone appeared in the same position in the PM. Cefepime showed main characteristic bands at 2935 cm −1 , 1773.29 cm-1 , and 1655 cm −1 corresponding to O-H stretching, β-lactam C=O stretching, and amide C=O, respectively.…”

Section: Characterizations Of Tdnmentioning

confidence: 94%

“…Figure 3C shows the DSC thermograms of the ceftriaxone system. The drug produced its melting point endothermic peak at 181°C, 25 thermogram of the PM. Cefepime produced its characteristic peak at 185°C which is corresponding to its melting point.…”

Section: Characterizations Of Tdnmentioning

confidence: 99%

“…Notes: no**, number of Pseudomonas aeruginosa isolates; *Percentages were correlated with total number of the selected Pseudomonas aeruginosa isolates(25).…”

mentioning

confidence: 99%

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Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR Pseudomonas aeruginosa Strains

Ahmed¹,

Aly²,

El-Baky³

et al. 2020

IJN

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Introduction: The efficacy of several antimicrobial agents has been hindered due to the increasing frequency of multidrug-resistant (MDR) Pseudomonas aeruginosa strains. So, the need for new antibacterial drugs or drug combinations is urgent. Recently, desirable antibacterial effects were reported for many metals nanoparticles such as TiO 2 nanoparticles (TDNs). Purpose: This study aims to investigate the prevalence of MDR P. aeruginosa and assess the efficiency of TDN in the treatment of MDR P. aeruginosa-associated infections. Materials and Methods: The synthesis of TDN by the sol-gel method was carried out. Particle size measurements and morphology were done using dynamic light scattering (DLS) and high-resolution transmission electron microscopy (HR-TEM). To investigate the physical and chemical changes of drugs due to the combination, the tested drugs, both alone and in combination with TDN, were subjected to differential scanning calorimetry (DSC), infrared (IR) spectroscopy, and X-ray diffraction studies. Antimicrobial susceptibility was detected by agar disc-diffusion assay. The minimum inhibitory concentration (MIC) of TDN and the tested antibiotics were assessed by the agar dilution method. Checkerboard analysis was performed to determine the combined effect of TDN and the tested antibiotics against 25 MDR P. aeruginosa strains. Results: TDNs were prepared with an average particle size of 64.77 ± 0.14 nm with an accepted polydispersity index (PDI) value of 0.274 ± 0.004. TEM showed that the particles were shaped into irregular spheres. Twenty-five P. aeruginosa isolates that were absolutely resistant to cefepime (100%), highly resistant to ceftriaxone (96%), amikacin (80%), and ciprofloxacin (76%) were selected. Superior antibacterial activity of TDN was observed against the selected 25 MDR P. aeruginosa isolates. The combination of TDN and cefepime were found to show synergistic activity against all tested isolates followed by ceftriaxone (96%), amikacin (88%), and ciprofloxacin (80%). Conclusion: Using TDN in combination with antibiotics can help in the treatment of MDR P. aeruginosa-associated infections. So, preparation of topical pharmaceutical dosage forms containing a combination of these antibiotics and TDN can be useful against MDR P. aeruginosa.

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Section: Characterizations Of Tdnmentioning

confidence: 94%

Section: Characterizations Of Tdnmentioning

confidence: 99%

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Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR Pseudomonas aeruginosa Strains

Ahmed¹,

Aly²,

El-Baky³

et al. 2020

IJN

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“…A very neoteric endeavor was recently published by the authors in which a new perspective enteric-coated tablet dosage form for oral administration of CTX was maneuvered. 3 The promising results of this survey made the authors more eager to dedicate the present study with an epochal strategy that could accomplish the oral march of CTX with better bioavailability and sustained release.…”

Section: Introductionmentioning

confidence: 92%

“…The oral absolute bioavailability (F) was calculated from the relationship = (oral AUC 0-∞ /IV AUC 0-∞ ), where IV AUC 0-∞ is for intravenously administered CTX. 3 The mean residence time (MRT) was calculated as the ratio of area under the first moment curve (AUMC 0-∞ ) to (AUC 0-∞ ) where the mean absorption time (MAT) was the difference between oral MRT and that after IV one. 3 K abs is the firstorder absorption rate constant, and it was calculated as 1/ MAT; while the absorption half-life (T 1/2abs ) was calculated as 0.693/K abs .…”

Section: Pharmacokinetic Data Analysismentioning

confidence: 99%

Design and Optimization of New Enteric Nanoparticles of Ceftriaxone for Oral Delivery: In vitro and in vivo Assessments

Maghrabia¹,

Boughdady²,

Meshali³

2021

IJN

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Purpose: Development of new strategies for oral delivery of existing antibiotics administered exclusively through intravenous route is one of the global priorities of pharmaceutical research. The encapsulation of these active pharmaceutical agents within nanosized natural products offers several traits due to their tunable surface properties. Ceftriaxone (CTX) is an injectable, third-generation cephalosporin that suffers poor oral bioavailability. Methods: In the present study, ionic gelation of two biopolymers, namely chitosan (CH) and shellac (SH), was implemented to consolidate CTX, within elegant nanoparticles (NPs) for oral administration that would increase its bioavailability and sustainability. Quality by design approach (2 3 full factorial design) was adopted to optimize CTX-loaded nanoparticles. The optimized formula (F2) was characterized through transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). In vitro release behavior and stability study were also evaluated. Pharmacokinetic studies of enteric-coated hard gelatin capsules (HGCs) loaded with F2-NPs were finally assessed. Results: The optimized spherical F2-NPs had a mean particle size of 258 nm, zeta potential of about +30.1 and appreciable drug entrapment efficiency of 83%. The in vitro drug release profile of F2-NPs in pH 7.4 experienced biphasic configuration with an initial burst release for an hour, followed by a sustained release over 15 h with Higuchi model and non-Fickian diffusion mechanism (R 2 =0.9852). High stability upon storage at refrigerated and room temperature for 3 months and good flow properties (θ= 32.2 and HR= 1.13) of the optimized formula were also conferred. In vivo pharmacokinetic assessment in rabbits fruitfully displayed 92% absolute bioavailability of CTX. Conclusion:The obtained results provide evidence for the potential combination of CH and SH in NPs preparation to enhance the oral bioavailability of CTX.

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Application or function of citric acid in drug delivery platforms

Pooresmaeil

Javanbakht

Namazi

et al. 2021

Medicinal Research Reviews

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Nontoxic materials with natural origin are promising materials in the designing and preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted a great deal of attention because of its special features; green nature, biocompatibility, low price, biodegradability, and commercially available property. So, CA has been employed in the preparation of the various platforms to induce a suitable property on their structure. Recently, several research groups investigated the CA‐based platforms in different forms like tablets, dendrimers, hyperbranched polymers, (co)polymer, hydrogels, and nanoparticles as efficient DDSs. By considering an increasing amount of published articles in this field, for the first time, in this review, an overview of the published works regarding CA applications in the design of various DDSs is presented with a detailed and insightful discussion.

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New Perspective Enteric-Coated Tablet Dosage Form for Oral Administration of Ceftriaxone: In Vitro and In Vivo Assessments

Cited by 15 publications

References 34 publications

<p>Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR <em>Pseudomonas aeruginosa</em> Strains</p>

<p>Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR <em>Pseudomonas aeruginosa</em> Strains</p>

Design and Optimization of New Enteric Nanoparticles of Ceftriaxone for Oral Delivery: In vitro and in vivo Assessments

Application or function of citric acid in drug delivery platforms

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