New Perspectives of HIV/AIDS Therapy Study

Lu, Da-Yong; Lu, Ting-Ren; Che, Jin-Yu; Wu, Hongying; Xu, Bin

doi:10.2174/1574891x10666150109115402

Cited by 13 publications

(20 citation statements)

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“…Several pathological pathways have been contributed for this key drawback. One of the challenges in HIV/AIDS study is the possible relationships between HIV genetic penetrations and disease pathogenic progresses (human mortalities) [4][5][6].…”

Section: Current Therapeutic Limitationmentioning

confidence: 99%

“…Among all these unknown territories, the study of HIV-genomic integration is the relatively earliest one [4][5][6].…”

Section: Problem Originsmentioning

confidence: 99%

“…In these researches, physical states of DNA polymers were used as substrates for integrase activity evaluations and inhibitory efficacy comparisons [4]. Meanwhile, a series of integrase inhibitors have been verified and even licensed [4][5][6]. Shortly afterwards, a number of sophisticated scientific investigation roadmaps have been designed [8,9].…”

Section: Problem Originsmentioning

confidence: 99%

“…Following sections address these insights into the fields of HIV/AIDS studies and highlights with new ideas and clinical achievements. One of the most mortality impacts of HIV-induced pathogenesis might be virus-human genome penetrations in infected cells or tissues, which are irreversible by present clinical therapeutics [4][5][6]. But they are the targets of many biotherapies [17][18][19][20].…”

Section: Next Generation Sequencingmentioning

confidence: 99%

“…In these initial studies, a great amount of HIV pieces can penetrate into DNA polymers as fast as 4 hrs [4]. By utility of this experimental model, a series of HIV/AIDS therapeutic agents (integrate inhibitors) have been developed and finally licensed [4][5][6][14][15][16][17].…”

mentioning

confidence: 99%

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HIV in Human Genomes and Therapeutics

Lu¹,

Lü²,

Yarla³

et al. 2017

HIV Curr Res

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One of the most interesting topics in the field of HIV/AIDS study is the possible relationship between HIV genetic penetrations and disease stages. One decade before, this kind of genomic information is difficult to achieve. Yet, the innovations of next generation sequencing (NGS) have changed this landscape. At present, new generations of bio-therapies target this undesired pathogenic pathways. In this article, we address the relationships between HIV-induced genomic changes across the history and different types of therapeutics have been testified since last decade-including integrate inhibitors, genome editing agents and therapeutic schedules. Future perspectives are also given. HIV in Human Genomes and Therapeutics Knowledge EvolutionPhysical states of DNA polymers in pathologic and therapeutic studiesAt the beginning of this millennium, genomic drafting was a huge task hardly finished by single lab or even an institute. Owing to this situation, physical states of DNA samples were used to identify smallsegments of HIV genome integration into physical states of DNA polymers. In these initial studies, a great amount of HIV pieces can penetrate into DNA polymers as fast as 4 hrs [4]. By utility of this experimental model, a series of HIV/AIDS therapeutic agents (integrate inhibitors) have been developed and finally licensed [4-6,14-17].Since integrase inhibitors were usually developed by DNA polymer substrate techniques, the situation of clinical therapeutic improvements were uncertainty. It means that DNA polymer conditions are not completely parallel with complicate conditions in living cells and bodies-including HIV infected patients. As a result, more sophisticate living conditions (in vitro or in vivo experimental models) must be established, and even utilized as HIV therapeutic drug evaluating systems. Different types of animal models and human cell modelsBefore clinical human genomic pathological and therapeutic studies, in vitro or in vivo animal models for HIV genomic integration must be utilized first. In animal model studies, selections of animal genomic origin and human cell/tissue types are important.There are similarity and diversity among different animal genomic origins and human cell types. These types of animal/human genomic studies generally needs less ethical requirements and can be studied in repeat ways comparing with clinical human investigations. In our opinions, these types of HIV genomic penetration studies should be emphasized now and in future. Similarly, these types of HIV animal

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Section: Current Therapeutic Limitationmentioning

confidence: 99%

“…Among all these unknown territories, the study of HIV-genomic integration is the relatively earliest one [4][5][6].…”

Section: Problem Originsmentioning

confidence: 99%