New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota

Lee, Heetae; Ko, GwangPyo

doi:10.1080/19490976.2017.1353842

Cited by 28 publications

(17 citation statements)

References 33 publications

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“…Research in the enteric viruses and their interactions with the microbiota will probably pave the way for the development of new microbiota-targeting antiviral therapies. Many possibilities exist, including the use of bacteria with enhancing properties for the development of more effective oral vaccines (e.g., RV vaccines) or the modulation of the intestinal microbiota through different interventions (e.g., dietary interventions [ 87 ]) aimed at selecting a microbiota more prone to restrict RV or NoV replication.…”

Section: Discussionmentioning

confidence: 99%

The Interactions between Host Glycobiology, Bacterial Microbiota, and Viruses in the Gut

Monedero

Buesa

Rodrı́guez-Dı́az

2018

Viruses

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Rotavirus (RV) and norovirus (NoV) are the major etiological agents of viral acute gastroenteritis worldwide. Host genetic factors, the histo-blood group antigens (HBGA), are associated with RV and NoV susceptibility and recent findings additionally point to HBGA as a factor modulating the intestinal microbial composition. In vitro and in vivo experiments in animal models established that the microbiota enhances RV and NoV infection, uncovering a triangular interplay between RV and NoV, host glycobiology, and the intestinal microbiota that ultimately influences viral infectivity. Studies on the microbiota composition in individuals displaying different RV and NoV susceptibilities allowed the identification of potential bacterial biomarkers, although mechanistic data on the virus–host–microbiota relation are still needed. The identification of the bacterial and HBGA interactions that are exploited by RV and NoV would place the intestinal microbiota as a new target for alternative therapies aimed at preventing and treating viral gastroenteritis.

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Section: Discussionmentioning

confidence: 99%

The Interactions between Host Glycobiology, Bacterial Microbiota, and Viruses in the Gut

Monedero

Buesa

Rodrı́guez-Dı́az

2018

Viruses

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“…The administration of retinoic acid (physiologically active vitamin A metabolite) in patients with norovirus infection significantly increased the abundance of Lactobacillus spp. Since Lactobacillus showed antiviral activity in vitro, it has been hypothesized that the intake of vitamin A and the consequent increase in the amount of Lactobacillus in the gut were partially responsible for norovirus inhibition [100]. Retinoic acid administration has also been shown to increase the relative abundance of Allobaculum, Aggregatibacter, Bifidobacterium, Dialister and [93].…”

Section: Micronutrients and Microbiotamentioning

confidence: 99%

Natural Compounds in the Modulation of the Intestinal Microbiota: Implications in Human Physiology and Pathology

Spisni¹,

Turroni²,

Shahaj³

et al. 2021

Alternative Medicine - Update

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Clinical interest in the human gut microbiota has increased considerably, because of the increasing number of studies linking the human intestinal microbiota and microbiome to an ever increasing number of non-communicable diseases. Many attempts at modulating the gut microbiota have been made using probiotics and prebiotics. However, there are other avenues that are still little explored from a clinical point of view that appear promising to obtain modifications of the microbial ecology and biological activities connected to the microbiome. This chapter summarizes all in vitro, in vivo and clinical studies demonstrating the possibility to positively modulate the intestinal microbiota by using probiotics, foods (and prebiotics), essential oils, fungus and officinal plants. For the future, clinical studies investigating the ability to modify the intestinal microbiota especially by using foods, officinal and aromatic plants or their extracts are required. More knowledge in this field is likely to be of clinical benefit since modulation of the microbiome might support the therapy of most non-communicable diseases in the future.

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“…Collectively, the available data point to a beneficial effect of vitamins’ supplementation on GM, which seems to depend on the concentration/dose. Finally, vitamin A has been suggested as an adjuvant therapy for infectious diseases, including viral, possibly due to GM modulation [ 142 , 143 ]. In fact, vitamin A supplementation (as retinoic acid) was able to inhibit norovirus replication in a murine model, which was accompanied by significantly increased abundance of Lactobacillus , which could be the responsible for the antiviral effect [ 142 , 143 ].…”

Section: Therapeutic Opportunities For Covid-19 With Impact On Thementioning

confidence: 99%

Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

2020

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Coronavirus Disease 2019 (COVID-19) is a pandemic infection caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients present a complex clinical picture that, in severe cases, evolves to respiratory, hepatic, gastrointestinal, and neurological complications, and eventually death. The underlying pathophysiological mechanisms are complex and multifactorial and have been summarized as a hyperresponse of the immune system that originates an inflammatory/cytokine storm. In elderly patients, particularly in those with pre-existing cardiovascular, metabolic, renal, and pulmonary disorders, the disease is particularly severe, causing prolonged hospitalization at intensive care units (ICU) and an increased mortality rate. Curiously, the same populations have been described as more prone to a gut microbiota (GM) dysbiosis profile. Intestinal microflora plays a major role in many metabolic and immune functions of the host, including to educate and strengthen the immune system to fight infections, namely of viral origin. Notably, recent studies suggest the existence of GM dysbiosis in COVID-19 patients. This review article highlights the interplay between the triad GM dysbiosis–immune hyperresponse–inflammation in the individual resilience/fragility to SARS-CoV-2 infection and presents the putative impact of pharmacological and nutraceutical approaches on the triumvirate, with focus on GM.

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New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota

Cited by 28 publications

References 33 publications

The Interactions between Host Glycobiology, Bacterial Microbiota, and Viruses in the Gut

The Interactions between Host Glycobiology, Bacterial Microbiota, and Viruses in the Gut

Natural Compounds in the Modulation of the Intestinal Microbiota: Implications in Human Physiology and Pathology

Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

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