1995
DOI: 10.1080/10575639508044083
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New Phenalenone-type Phytoalexins fromMusa acuminata(Colla AAA) Grand Nain

Abstract: Four new phenalenone-type phytoalexins (2 -5) have been isolated from rhizomes of Musa acumituzta (AAA) infected with the fungus Fusurium oxysporum. The structures of the new phytoalexins were elucidated using spectroscopic evidence, chemical correlation, synthesis, and X-ray diffraction analysis. The major compound 2, has been previously described as a natural product, named anigorufone, but never as a phytoalexin. The chemical shift for all of the hydrogen and carbon atoms in the substances were unanibiguous… Show more

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Cited by 37 publications
(35 citation statements)
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“…has frequently profited by some natural antifungal drugs, such as amphotericin B, azole derivatives, paramomycin, saponins, and naphthoquinones (3,10,11,30), since similar pharmacological targets are present in these two groups of organisms. In fact, recent successful approaches to search for new leishmanicidal drugs profit from To test this strategy in phytoalexins, we assayed the leishmanicidal activity of two natural products, anigorufone and REF20 (25), and three related phenyl-phenalenone structures. These phytoalexins are synthesized under fungal challenge and showed antibiotic activity against the eliciting fungus, albeit their mechanism of action is completely unknown at present (25).…”
Section: Discussionmentioning
confidence: 99%
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“…has frequently profited by some natural antifungal drugs, such as amphotericin B, azole derivatives, paramomycin, saponins, and naphthoquinones (3,10,11,30), since similar pharmacological targets are present in these two groups of organisms. In fact, recent successful approaches to search for new leishmanicidal drugs profit from To test this strategy in phytoalexins, we assayed the leishmanicidal activity of two natural products, anigorufone and REF20 (25), and three related phenyl-phenalenone structures. These phytoalexins are synthesized under fungal challenge and showed antibiotic activity against the eliciting fungus, albeit their mechanism of action is completely unknown at present (25).…”
Section: Discussionmentioning
confidence: 99%
“…In fact, recent successful approaches to search for new leishmanicidal drugs profit from To test this strategy in phytoalexins, we assayed the leishmanicidal activity of two natural products, anigorufone and REF20 (25), and three related phenyl-phenalenone structures. These phytoalexins are synthesized under fungal challenge and showed antibiotic activity against the eliciting fungus, albeit their mechanism of action is completely unknown at present (25). The whole set of drugs caused the inhibition of both promastigote and amastigote proliferation with similar efficacy; moreover, the inhibition of amastigote proliferation was even better for EP5 and EP6.…”
Section: Discussionmentioning
confidence: 99%
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