2004
DOI: 10.1002/cbdv.200490109
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New Photoproducts from Irradiation of NADH with Near‐UV Light

Abstract: Adenosine 5'-diphosphoribose (ADPR) and a second compound, which may be nicotinamide, are the newly discovered photoproducts resulting from irradiation of beta-nicotinamide adenine dinucleotide (beta-NADH) in the wavelength range of 300-400 nm under oxygen-poor conditions. Both products emerge there even exclusively, whereas, at higher oxygen concentrations, the oxidized form of nicotinamide adenine dinucleotide (NAD+) is additionally formed, although still as a minor product. The development of ADPR and NAD+ … Show more

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Cited by 10 publications
(15 citation statements)
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“…This was shown to be true for 1,4‐NADH, as demonstrated by the 1 H NMR spectrum of a standard solution in phosphate buffer after irradiation for ∼12 h by the same UV‐LED used in the photoelectrochemistry experiment. NAD + and minor amounts of ADPR and free nicotinamide were detected, in agreement with findings published by Vitinius et al . UV light was employed in the initial photoelectrochemistry study to excite the direct band gap transition in p ‐GaP (2.3 eV) .…”
Section: Resultssupporting
confidence: 89%
“…This was shown to be true for 1,4‐NADH, as demonstrated by the 1 H NMR spectrum of a standard solution in phosphate buffer after irradiation for ∼12 h by the same UV‐LED used in the photoelectrochemistry experiment. NAD + and minor amounts of ADPR and free nicotinamide were detected, in agreement with findings published by Vitinius et al . UV light was employed in the initial photoelectrochemistry study to excite the direct band gap transition in p ‐GaP (2.3 eV) .…”
Section: Resultssupporting
confidence: 89%
“…This absorption peak was significantly reduced after heat treatment at 150 8C. Our observation of an absorbance maximum near 340 nm in the absorption spectrum is consistent with previous reports [35,36] and enabled us to identify NADH with strong adsorption near 340 nm and NAD þ with negligible adsorption. The effect of heat treatment in the SWCNT channel was clearly visible in Figure 2b and c. After a simple drying at 40 8C, the magnitude of I DS was decreased by two orders of magnitude for an applied negative V G compared to the asprepared sample.…”
Section: Resultssupporting
confidence: 80%
“…This could be due not only to the reduced generation of 1,4-NADH (which has been proved to also contribute to the generation of Ru-H species) [30] but also due to possible simultaneous photodegradation of 1,4-NADH to NAD + upon photoirradiation by UVA (λ irr = 300-400 nm), as it has been recently suggested NAD + is indicated in dark green and 1,4-NADH in red. [31]. It is believed that NAD + , adenosine 5'-diphosphoribose (ADPR) and a second compound, which may be nicotinamide (NA) are the photoproducts resulting from long-time exposures (2 days) of 1,4-NADH to UVA photoirradiation (λ irr = 300-400 nm) in water and normal O 2 levels form the atmosphere.…”
Section: Discussionmentioning
confidence: 99%