New PMMA-co-EHA glass-filled composites for biomedical applications: Mechanical properties and bioactivity

Lopes, Poliana Pollizello; Corbellini, Marcelo Peixer; Ferreira, B.J.M. Leite; Almeida, Nuno A.F.; Fredel, Márcio C.; Fernandes, Maria Helena; Correia, Raquel

doi:10.1016/j.actbio.2008.07.012

Cited by 27 publications

(24 citation statements)

References 35 publications

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“…They remain the most common materials used for fixation of prostheses for total hip and knee replacements, as well as in ankle, elbow or shoulder replacements . PMMA‐based bone cements are responsible for fixation of an implant to the bone, and they act as load distributor between metal prosthesis and living tissue . They are also applied to fill bone defects and to stabilize compressive vertebral fractures .…”

Section: Introductionmentioning

confidence: 99%

Modification of acrylic bone cements by poly(ethylene glycol) with different molecular weight

Król

Pielichowska

2016

Polymers for Advanced Techs

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The high polymerization temperature of acrylic bone cements can cause arthroplasty failure because of the thermal necrosis of surrounding bone tissue. To reduce this undesired effect we have developed novel acrylic bone cement composites containing a phase change material (PCM). As PCM poly(ethylene glycol) (PEG) of different molecular weight was applied and the effect of its incorporation on curing parameters, mechanical and morphological properties of acrylic bone cement was investigated. A significant decrease in maximum temperature from 65.8°C to 47.4°C and slight increase of setting time were observed. PEG introduction also contributed to the thermal stability of acrylic bone cement increase. SEM investigation of modified bone cement confirmed that the microstructure does not alter considerably because of PEG content. It was found that both PEG addition and incubation test contribute to an inconsiderable decrease in mechanical strength of bone cement. However, the mechanical strength increase can be caused by the fresh bone tissue incorporation into the pores appearing in bone cement.

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Section: Introductionmentioning

confidence: 99%

Modification of acrylic bone cements by poly(ethylene glycol) with different molecular weight

Król

Pielichowska

2016

Polymers for Advanced Techs

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“…When the filler begins to aggregate it behaves like voids in the bone cement, thereby weakening it. Therefore, the strength is reduced even if the filler is strong enough to increase the elastic modulus of the material . In the present case we believe that, apart from the filler content, it is the higher viscosity of samples C1, C2, and C3 that contributes to an inhomogeneous distribution (and possible agglomeration) of the HA particles.…”

Section: Resultsmentioning

confidence: 60%

Properties of novel PMMA‐co‐EHA bone cements filled with hydroxyapatite

et al. 2013

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To design bone cements with predictable intraoperative and postoperative behavior, researchers must understand how cement formulations affect the polymerization reaction and specially the properties of the end product. In this study, a bioactive filler (commercial hydroxyapatite, HA) was incorporated into poly(methyl methacrylate)-co-ethyl hexyl acrylate (PMMA-co-EHA) matrices to prepare new bone cement formulations. The new PMMA-co-EHA/HA composites were obtained by varying the relative contents of the monomers, MMA, and EHA. The resulting composites were evaluated in terms of the curing parameters, water uptake and weight loss in phosphate buffer solution and mechanical properties. The results obtained showed that incorporation of 25% HA particles induced major changes in the final properties of the bone cements comparing with the unfilled parent matrices. In particular, the peak temperature decreased and the setting time and the bending elastic modulus increased in all formulations containing HA particles. Composites with low EHA content exhibited a decrease in strength after HA incorporation, which was attributed to the poor interfacial adhesion between the components of the composites. Additionally, the immersion results showed that the amount of 25% HA (regarding the total mass) in the composites was not enough to induce in vitro bioactive properties in the materials. POLYM. COMPOS., 35:759-767, 2014.

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“…In general, for long survival, the gap is filled with bone cement. Mechanical properties of bone cement and its various nanocomposites have been determined from stress–strain behavior under uniaxial tension 44. Figure 8(a,b) shows the stress–strain curves of bone cement and its nanocomposites prepared in benzene and DMF solvents.…”

Section: Resultsmentioning

confidence: 99%

Toughening of bone cement using nanoparticle: The effect of solvent

Misra

Kapusetti

Jaiswal

et al. 2011

J of Applied Polymer Sci

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Drawbacks of poly(methyl methacrylate) (PMMA)-based bone cement as a grouting agent for in vivo fixation of orthopedic and dental implants such as considerable low mechanical strength have been improved using nanotechnology. Bone cement-layered silicate nanocomposites have been prepared without any heat treatment in the presence of polar (dimethyl formamide, DMF) and nonpolar (benzene) solvents. Solvents have been removed completely from the bone cement after its preparation. Nanostructure is very much dependent on the solvent used for nanocomposite preparation, and benzenebased nanocomposites are highly intercalated, whereas DMF-based nanocomposites do not exhibit intercalation. Thermal stability of bone cement has improved in the presence of nanoclays. The relative enhanced interaction in case of benzene-based nanocomposites has been shown through FTIR and UV-vis studies. The significant improvement in modulus and toughness of bone cement has been demonstrated in the presence of minimum amount of nanoclay for benzene-based nanocomposites, whereas no change in modulus and reduced toughness have been observed for DMF-based nanocomposites. The decrease of contact angle has been witnessed with increasing nanoclay concentration indicating better hydrophilic materials suitable for biomedical applications for greater cell growth. The reason for varying property enhancement in different solvents has been discussed considering the polarity effect and interactions.

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New PMMA-co-EHA glass-filled composites for biomedical applications: Mechanical properties and bioactivity

Cited by 27 publications

References 35 publications

Modification of acrylic bone cements by poly(ethylene glycol) with different molecular weight

Modification of acrylic bone cements by poly(ethylene glycol) with different molecular weight

Properties of novel PMMA‐co‐EHA bone cements filled with hydroxyapatite

Toughening of bone cement using nanoparticle: The effect of solvent

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