New Poly(3-hydroxybutyrate) Microparticles with Paclitaxel Sustained Release for Intraperitoneal Administration

Бонарцев, А. П.; Zernov, A.L.; Yakovlev, Sergey; Zharkova, I. I.; Мышкина, В. Л.; Mahina, T.K.; Бонарцева, Г. А.; Андронова, Н.В.; Smirnova, G. P.; Borisova, Juliya A.; Kalishjan, M. S; Шайтан, К. В.; Treshalina, H. M.

doi:10.2174/1871520615666160504095433

Cited by 12 publications

(8 citation statements)

References 18 publications

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“…This production method allows varying the physicochemical properties of polymers of this type over a wide range [12]. Because PHB has the ability to biodegrade and has high biocompatibility, it is widely used for biomedical applications in regenerative medicine and tissue engineering [13][14][15][16][17][18][19][20][21][22] and medicine forms [23][24][25][26]. It is able to create composites with synthetic polymers, inorganic materials [19,[27][28][29] and also as a new environmentally friendly material, including application as a material for the packaging industry [15,24,30,31].…”

Section: Introductionmentioning

confidence: 99%

Comparative Structure-Property Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)s Films under Hydrolytic and Enzymatic Degradation: Finding a Transition Point in 3-Hydroxyvalerate Content

et al. 2020

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The hydrolytic and enzymatic degradation of polymer films of poly(3-hydroxybutyrate) (PHB) of different molecular mass and its copolymers with 3-hydroxyvalerate (PHBV) of different 3-hydroxyvalerate (3-HV) content and molecular mass, 3-hydroxy-4-methylvalerate (PHB4MV), and polyethylene glycol (PHBV-PEG) produced by the Azotobacter chroococcum 7B by controlled biosynthesis technique were studied under in vitro model conditions. The changes in the physicochemical properties of the polymers during their in vitro degradation in the pancreatic lipase solution and in phosphate-buffered saline for a long time (183 days) were investigated using different analytical techniques. A mathematical model was used to analyze the kinetics of hydrolytic degradation of poly(3-hydroxyaklannoate)s by not autocatalytic and autocatalytic hydrolysis mechanisms. It was also shown that the degree of crystallinity of some polymers changes differently during degradation in vitro. The total mass of the films decreased slightly up to 8–9% (for the high-molecular weight PHBV with the 3-HV content 17.6% and 9%), in contrast to the copolymer molecular mass, the decrease of which reached 80%. The contact angle for all copolymers after the enzymatic degradation decreased by an average value of 23% compared to 17% after the hydrolytic degradation. Young’s modulus increased up to 2-fold. It was shown that the effect of autocatalysis was observed during enzymatic degradation, while autocatalysis was not available during hydrolytic degradation. During hydrolytic and enzymatic degradation in vitro, it was found that PHBV, containing 5.7–5.9 mol.% 3-HV and having about 50% crystallinity degree, presents critical content, beyond which the structural and mechanical properties of the copolymer have essentially changed. The obtained results could be applicable to biomedical polymer systems and food packaging materials.

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Section: Introductionmentioning

confidence: 99%

Comparative Structure-Property Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)s Films under Hydrolytic and Enzymatic Degradation: Finding a Transition Point in 3-Hydroxyvalerate Content

et al. 2020

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“…In this study earlier developed techniques [ 72 ] for the fabrication of “empty” and SVN-loaded poly(3-hydroxybutyrate) microbeads were used. The microbeads were prepared under the particular conditions indicated in Section 3.2.1 .…”

Section: Resultsmentioning

confidence: 99%

“…Also, numerous round caverns (pores) of 2–20 μm in diameter can be distinguished on the surface of microbeads ( Figure 1 b,c). These structural elements are known [ 72 ] to be formed when small drops of aqueous phase were entrapped into the organic phase (chloroform solution of PHB) upon the emulsification of PHB/chloroform and aqueous ammonium carbonate solutions ( Section 3.2.1 ). It is clear that the presence of such pores in the bulk of the PHB matter increases the inner surface of the microbeads, thus facilitating their absorption capacity with respect to the relatively hydrophobic substances.…”

Section: Resultsmentioning

confidence: 99%

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Cryo-Structuring of Polymeric Systems. Poly(Vinyl Alcohol)-Based Cryogels Loaded with the Poly(3-hydroxybutyrate) Microbeads and the Evaluation of Such Composites as the Delivery Vehicles for Simvastatin

et al. 2022

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Highly porous composite poly(vinyl alcohol) (PVA) cryogels loaded with the poly(3-hydroxybutyrate) (PHB) microbeads containing the drug, simvastatin (SVN), were prepared via cryogenic processing (freezing—storing frozen—defrosting) of the beads’ suspensions in aqueous PVA solution. The rigidity of the resultant composite cryogels increased with increasing the filler content. Optical microscopy of the thin section of such gel matrices revealed macro-porous morphology of both continuous (PVA cryogels) and discrete (PHB-microbeads) phases. Kinetic studies of the SVN release from the drug-loaded microbeads, the non-filled PVA cryogel and the composite material showed that the cryogel-based composite system could potentially serve as a candidate for the long-term therapeutic system for controlled drug delivery. Such PHB-microbeads-containing PVA-cryogel-based composite drug delivery carriers were unknown earlier; their preparation and studies have been performed for the first time.

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“…simvastatin loaded PLGA particles), or lung cancer (e.g. methotrexate, carboplatin in gelatine, or paclitaxel) [90,91,[105][106][107][108],…”

Section: Applications Of Nano Spray Dried Pharmaceuticals On the Laboratory-scalementioning

confidence: 99%

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2018

Int J Med Nano Res

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Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug-containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder particles to the submicron-and nanoscale with very narrow size distributions and sample quantities in the milligram scale at high product yields. This enables the economical use of expensive active pharmaceutical ingredients and pure drugs. The present paper explains the concept of nano spray drying in the laboratory-scale and discusses the influence of the main process parameters on the final powder properties like particle size, morphology, encapsulation efficiency, and drug loading. Application results of nano spray drying for the formulation and encapsulation of different drugs are reviewed.

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New Poly(3-hydroxybutyrate) Microparticles with Paclitaxel Sustained Release for Intraperitoneal Administration

Abstract: The developed technique of PTX sustained delivery from PHB-microparticles has therapeutic potential as prolong anticancer drug formulation.

Cited by 12 publications

References 18 publications

Comparative Structure-Property Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)s Films under Hydrolytic and Enzymatic Degradation: Finding a Transition Point in 3-Hydroxyvalerate Content

Comparative Structure-Property Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)s Films under Hydrolytic and Enzymatic Degradation: Finding a Transition Point in 3-Hydroxyvalerate Content

Cryo-Structuring of Polymeric Systems. Poly(Vinyl Alcohol)-Based Cryogels Loaded with the Poly(3-hydroxybutyrate) Microbeads and the Evaluation of Such Composites as the Delivery Vehicles for Simvastatin

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