New Practical Synthesis of the Exceptional Musk Odorants (R)-Muscone and (R,Z)-5-Muscenone

Abstract

Herein we describe a short and practical synthesis of the exceptional musk odorants ( R )-muscone and ( R , Z )-5-muscenone from a readily available achiral macrocyclic diketone. The key step of the synthesis is the first sodium N -methylephedrate mediated enantioselective aldol condensation reaction (up to 76% ee). This new type of reaction proceeds via a dynamic kinetic resolution of an aldol intermediate.

Nanoscale Disorder and Deintercalation Evolution in K‐Doped MoS2 Analysed Via In Situ TEM

“…To achieve K intercalation we used the well-known liquidammonia method. [29] In brief, MoS 2 powder consisting of fewmicron size crystalline flakes is immersed in a liquid ammonia solution containing K at -78°C for 24 hours (see SI Figure S3c, Supporting Information for size and thickness distribution). Dissolved K atoms dissociate into solvated cations (K + ) and solvated electrons (e − ) as evident from the deep blue colour of the ammonia solution: [30,31] The color is the result of the emergence of a broad optical absorption line peaked at 0.85 eV and extending into the visible range.…”