New Predictive Parameters of Bell’s Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio

Atan, Doğan; İkincioğulları, Aykut; Köseoğlu, Sabri; Özcan, Kürşat Murat; Çetin, Mehmet Ali; Ensarı, Serdar; Dere, Hüseyin

doi:10.5152/balkanmedj.2015.15456

Cited by 44 publications

(35 citation statements)

References 12 publications

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“…Nevertheless, they had reported that there was no prognostic significance of lymphocyte subset analysis in peripheral blood to predict the outcome of patients with unsatisfactory recovery [6]. In a retrospective study conducted by Atan et al [10], NLR and PLR values were higher in the group of patients with Bell's palsy, but they found no correlation between these values and the level of facial paralysis [10]. Sahin et al [11] had showed that neutrophil counts and NLR value increase with in Bell palsy patients but there were no statistical significant changes of PLR, MPV and PDW values.…”

Section: Discussionmentioning

confidence: 99%

The role of inflammation markers in predicting the prognosis of Bell's palsy

Ulusoy

Bozdemir

Kale

et al. 2019

The European Research Journal

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Objectives:This study aimed to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) and Bell's palsy in addition to the usability of these markers to predict prognosis. Methods: In this prospective study, the patient group included 24 patients that were diagnosed with Bell's palsy and 29 healthy volunteers that had similar characteristics to them regarding age and gender with patient group as the control group. The temporal gadolinium-enhanced magnetic resonance imaging (TGd-MRI) was performed to all patients. The complete blood count was also obtained from both the patient and the control groups, and these two groups were compared for NLR and PLR, mean platelet volume (MPV), platelet distribution width (PDW), and platelet count. The relationship between these markers and Bell's paralysis prognosis was also investigated. Results: The patient and control groups were similar in age and gender (p > 0.05). NLR was significantly higher in the patient group compared with the control group (p = 0.016). There was no correlation between the NLR value and the prognosis of Bell's Palsy. The PDW and white blood cell count (WBC) were significantly higher in the patient group than the control group (p = 0.023 and p = 0.012, respectively). A comparison of the recovered and unrecovered patients revealed that the PDW value was significantly higher and the platelet count was lower in the recovered patients than the unrecovered patients (p = 0.009 and p = 0.003 respectively). The MPV value was higher in the recovered patients, though not statistically significant (p = 0.063). Based on the cut-off values determined in the receiver operator characteristic (ROC) curve analysis, a comparison of the recovered and unrecovered patients reveals that the likelihood of not healing was significantly higher in those that had normal PDW values (p = 0.036). Conclusion: These results might support the theory of inflammation in patients with Bell's palsy.

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Section: Discussionmentioning

confidence: 99%

The role of inflammation markers in predicting the prognosis of Bell's palsy

Ulusoy

Bozdemir

Kale

et al. 2019

The European Research Journal

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“…(3) Inter-neuronal space increased. 4The bony fallopian canal is normal, with no sign of facial nerve compression by the fallopian canal bone [60][61][62][63] In recent years, it is found that the mean neutrophil-to-lymphocyte ratio and neutrophil values were higher in adult and pediatric patients with Bell's palsy [64,65] Similar changes in peripheral blood leukocyte subpopulations are also described in the process of a few inflammatory demyelinating diseases, such as during the acute stage of Guillain-Barré syndrome and in acute exacerbations of multiple sclerosis. Bell's palsy, such as Guillain-Barré syndrome, may be an acute demyelinating disease of the peripheral nerve system [68] An examination of the serum samples from patients with Bell's palsy showed elevated concentrations of cytokines interleukin-6 (IL-6), interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-α) were increased compared with control groups [69,70] In contrast to control populations, decreased percentages of total T cells (CD3) and T helper/inducing cells (CD4) have also been found in the acute phase of the disease.…”

Section: Anatomical Structurementioning

confidence: 99%

“…A high neutrophil-to-lymphocyte ratio (NLR) is considered as a reliable etiological indicator of disease severity in inflammatory disorders [58,59]. Studies have shown that the mean NLR and neutrophil values in adult and pediatric patients with BP were found to be significantly higher than in healthy controls [60][61][62][63]. This suggests changes in peripheral blood leukocyte subpopulations akin to those that occur in the process of a few inflammatory demyelinating diseases, such as during the acute stage of Guillain-Barré syndrome and during acute exacerbations of multiple sclerosis [64,65].…”

Section: Inflammationmentioning

confidence: 99%

The etiology of Bell’s palsy: a review

et al. 2019

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Bell's palsy is the most common condition involving a rapid and unilateral onset of peripheral paresis/paralysis of the seventh cranial nerve. It affects 11.5-53.3 per 100,000 individuals a year across different populations. Bell's palsy is a health issue causing concern and has an extremely negative effect on both patients and their families. Therefore, diagnosis and prompt cause determination are key for early treatment. However, the etiology of Bell's palsy is unclear, and this affects its treatment. Thus, it is critical to determine the causes of Bell's palsy so that targeted treatment approaches can be developed and employed. This article reviews the literature on the diagnosis of Bell's palsy and examines possible etiologies of the disorder. It also suggests that the diagnosis of idiopathic facial palsy is based on exclusion and is most often made based on five factors including anatomical structure, viral infection, ischemia, inflammation, and cold stimulation responsivity.

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“…In a study, PLR was observed to be higher in patients with BP compared to healthy individuals. But, they did not find any correlation between PLR and grade of BP [17]. In another study, MPV was found to be high in patients with BP.…”

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confidence: 84%