New Prognostic Factors in
Prostatic Carcinoma

Visakorpi, Tapio; Op, Kallioniemi; Koivula, Timo; Isola, Jorma

doi:10.1159/000474347

Cited by 26 publications

(8 citation statements)

References 46 publications

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“…A large number of studies have been published on the prognostic value of DNA¯ow cytometric SPF and ploidy levels in primary prostate cancer. 13,14 In this study the aim was to compare the DNA¯ow cytometric ®ndings in untreated primary prostate cancers with corresponding hormonally treated, locally recurrent prostate carcinoma specimens from the same patients. Both the frequency of DNA aneuploidy and the fraction of S-phase cells (SPF) were signi®cantly higher in tumours that had progressed during endocrine therapy.…”

Section: Discussionmentioning

confidence: 99%

Aneuploidy and rapid cell proliferation in recurrent prostate cancers with androgen receptor gene amplification

Koivisto

1997

Prostate Cancer Prostatic Dis

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Mechanisms of prostate cancer recurrence during androgen deprivation are poorly understood. We recently described androgen receptor (AR) gene ampli®-cation in 28% of recurrent prostate carcinomas from hormone-refractory prostate cancer patients. To investigate the hypothesis that ampli®cation of the AR gene promotes the growth of hormone-refractory prostate carcinomas, DNA¯ow cytometric (FCM) studies were carried out to compare matched, primary and hormone-refractory recurrent samples from 31 prostate cancer patients. Recurrent tumours had a higher (P 0.05) S-phase fraction (SPF) (10.6 AE 4.6) than corresponding primary tumours from the same patients (7.0 AE 4.1) and the frequency of aneuploidy also increased from 8±55%. Recurrent tumours with AR gene ampli®cation had a signi®cantly higher (P 0.02) SPF (14.0 AE 6.5) than those with no ampli®cation (9.0 AE 2.9). The results suggest that clinical progression of prostate cancer during androgen withdrawal therapy is often associated with increased cell proliferation rate and formation of DNA aneuploidy. AR ampli®-cation may be an important molecular mechanism underlying the increase in proliferation rate of some recurrent tumours.

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Section: Discussionmentioning

confidence: 99%

Aneuploidy and rapid cell proliferation in recurrent prostate cancers with androgen receptor gene amplification

Koivisto

1997

Prostate Cancer Prostatic Dis

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“…A review of 47 different DNA ploidy studies involving 3493 patients has indicated that in most studies DNA aneuploidy is positively correlated with high-grade tumours, advanced stage and, consequently, with short time to progression and death (Visakorpi et al, 1993). Most of these studies were performed on localised or locally advanced-stage disease.…”

Section: Patientsmentioning

confidence: 99%

Histopathological grading and DNA ploidy as prognostic markers in metastatic prostatic cancer

Jørgensen

Yogesan²,

Skjørten³

et al. 1995

Br J Cancer

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Sinary The present study compares the prognostic potential of tumour grade and DNA ploidy status in patients with advanced-stage prostatic cancer. Two outcome groups were selected on the basis of time to progression and survival after orchiectomy. A poor-outcome group consisted of 32 therapy-resistant patients who experienced disease progression during the first year after orchiectomy and subsequently death due to prostatic cancer during the following year. A good-outcome group consisted of 27 therapy-responsive patients who showed disease regression and no signs of progression during a 3 year follow-up. The

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“…On the other hand, many studies have demonstrated that an imbalance in the growth equation is one of the etiological factors of tumor progression. In other words, the up-regulation of cancer cell proliferation and/or deregulation of apoptosis have been reported to play crucial roles in carcinogenesis and malignant activities in various malignancies, including prostate cancer (1,2). In addition, angiogenesis is an important regulator of malignant aggressiveness, while dissemination via blood vessels is an important process for prognosis (3).…”

Section: Introductionmentioning

confidence: 99%

Expression of matrix metalloproteinase-10 in non-metastatic prostate cancer: Correlation with an imbalance in cell proliferation and apoptosis

Maruta

Miyata²,

Sagara³

et al. 2010

Oncology Letters

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Abstract. Matrix metalloproteinases (MMPs) are associated with cell invasion under various physiological and pathological conditions. Among MMPs, MMP-10 is reported to correlate with a high pT stage and progression in a variety of cancer types. However, the clinical and pathological significance of MMP-10 in human prostate cancer tissues remains unclear. This study aimed to clarify the role of MMP-10 in non-metastatic prostate cancer. Sixty-three specimens were obtained by radical prostatectomy. MMP-10 expression, Ki-67, CD34 and apoptotic cells were examined using an immunohistochemical technique and the terminal deoxynucleotidyl transferase-mediated nick end-labeling method. The proliferation index (PI), apoptotic index (AI), microvessel density (MVD) and cell renewal index (CRI=PI/AI) were calculated. The relationship between MMP-10 expression and clinicopathological features, as well as PI, AI, MVD and CRI were investigated. MMP-10 was mainly detected in cancer cell cytoplasm, and the proportion of MMP-10-expressing cancer cells (median 13.8%) was significantly higher (P<0.001) than non-tumoral gland cells (2.4%). Similarly, the proportion of MMP-10-expressing cancer cells was significantly higher (P=0.007) in stage pT3 (median 22.3%) than in pT2 (11.3%) tumors and was correlated with blood vessel invasion (P=0.025). In addition, its expression level correlated significantly with CRI (r=0.34, P=0.001), but not with PI, AI or MVD. Multivariate analysis identified MMP-10 expression to be closely associated with pT stage (OR 3.76, 95% CI 1.14-12.34, P=0.029). Our results suggest that the overexpression of MMP-10 produces an imbalance in cancer cell proliferation and apoptosis, thereby contributing to cancer cell progression of non-metastatic prostate cancer.

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New Prognostic Factors in Prostatic Carcinoma

Cited by 26 publications

References 46 publications

Aneuploidy and rapid cell proliferation in recurrent prostate cancers with androgen receptor gene amplification

Aneuploidy and rapid cell proliferation in recurrent prostate cancers with androgen receptor gene amplification

Histopathological grading and DNA ploidy as prognostic markers in metastatic prostatic cancer

Expression of matrix metalloproteinase-10 in non-metastatic prostate cancer: Correlation with an imbalance in cell proliferation and apoptosis

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