New protein genetic studies in six Amazonian Indian populations

Santos, Sidney Emanuel Batista dos; Ribeiro-dos-Santos, Ândrea; Guerreiro, João Farias; Santos, Emina; Weimer, Tânia de Azevedo; Callegari-Jacques, Sídia Maria; Mestriner, Moacyr Antonio; Franco, Maria Helena Lartigau Pereira; Hutz, Mara Helena; Salzano, Francisco M.

doi:10.1080/03014469800006752

Cited by 8 publications

(10 citation statements)

References 22 publications

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“…When the protein phenotype prevalences observed in these five tribes were compared with those for South American Indians in general (given in Santos et al, 1998), it was seen that they presented frequencies of RH ‫ء‬ R1, PGM1 ‫ء‬ 1, and ACP ‫ء‬ A lower than the averages observed in other groups, and frequencies of RH ‫ء‬ R2, ESD ‫ء‬ 1, and GLO ‫ء‬ 1 that are higher. However, before assuming that these may represent characteristic frequencies for Argentinian tribes, previous studies performed on them should be considered.…”

Section: Resultsmentioning

confidence: 93%

Genetic relationships between Amerindian populations of Argentina

Goicoechea

Carnese

Dejean

et al. 2001

American J Phys Anthropol

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A total of 495 individuals from five different Argentinian tribes was examined for variation in 23 blood group and protein genetic systems, and the results were integrated with previous data on some of these systems. These tribes generally present RH * R1, PGM1 * 1, and ACP * A frequencies lower and RH * R2, ESD * 1, and GLO * 1 prevalences higher than those observed in other South American Indian groups. Earlier studies with mitochondrial DNA showed that haplogroup A was present in low frequencies in these tribes, but haplogroup B showed a high prevalence among the Mataco. Average heterozygosities are very similar in the five tribes, while estimates of non-Indian ancestry are generally low. Both the blood group and protein, as well as the mtDNA data sets, divide the five tribes into two groups, and the relationships obtained with the blood group and protein systems are exactly those expected on the basis of geography and language. However, the topology obtained with the mtDNA results was different, possibly due to sampling effects or diverse patterns of exchange between the groups related to sex.

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Section: Resultsmentioning

confidence: 93%

Genetic relationships between Amerindian populations of Argentina

Goicoechea

Carnese

Dejean

et al. 2001

American J Phys Anthropol

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“…Since the first genetic studies on the Yanomama, the Makiritare, and their neighboring populations from Venezuala and northern Brazil (Layrisse et al, 1962;Arends et al, 1967Arends et al, , 1970Chagnon et al, 1970;Gershowitz et al, 1970Gershowitz et al, , 1972Ward et al, 1970Ward et al, , 1975Weitkamp and Neel, 1970;Ward and Neel, 1976;Neel et al, 1977Neel et al, , 1980Neel, 1978;Smouse and Ward, 1978), the Amazonian Native populations have gathered much interest from the genetic point of view and reports are nowadays numerous for the classical markers (Matson et al, 1968;Geerdink et al, 1974a,b;Kirk et al, 1974;Black et al, 1988;Salzano et al, 1988Salzano et al, , 1997aCallegari-Jacques and Salzano, 1989;Callegari-Jacques et al, 1994;Cavalli-Sforza et al, 1994;Olsson et al, 1998;Santos et al, 1998;Battilana et al, 2002;Barjas-Castro et al, 2003). Recently, molecular genetics is also yielding inferences for the present and past societies of this peculiar area of South America (Ribeiro dos Santos et al, 1996;Bortolini et al, 1998;Fagundes et al, 2002;Dornelles et al, 2004Dornelles et al, , 2005Kohlrausch et al, 2005).…”

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confidence: 99%

Genetic studies in French Guiana populations: Synthesis

Mazières

Sevin

Bonnet

et al. 2006

American J Phys Anthropol

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Twelve blood group and protein systems from a total of 819 individuals from six tribal groups (Apalaí-Wayana, Emerillon, Kaliña, Palikur Wayampi, and Wayana) living in French Guiana and Brazil were compared with each other and integrated with previous results from 17 other South Amerindian populations studied for the same genetic markers. Using correspondence analysis, map methodologies, and maximum linkage cluster analysis developed with the UPGMA method, we attempted to establish the genetic position of these tribes among South American Indians. Peripheral positions for the Emerillon and the Palikur were observed. Ethnohistorical data in French Guiana suggest that a strong founder effect for the former and endogamy for the latter could have generated the genetic differentiation of these two ethnic groups. However, when considered in a wider context, all French Guiana Natives cluster together in an intermediate position as compared with 17 other Amerindian groups studied for the comparison.

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“…The Hp *1 allele frequency in the Kalunga (58%) was also similar to that described for the African continent (0.56) and North America (0.55), but higher than in Asia (0.27) (Carter and Worwood, 2007), probably because of the contribution of Afro-descendants that formed the quilombo. For the Kayabi, the frequency of the Hp *1 allele (44%) was similar to that reported for three South American Amerindian populations, viz., the Makiritare (42%), Kubenkokre (49%) (Arends et al , 1970; Santos et al , 1998) and the French Guiana population of Kaliña (44.5%) (Mazières et al , 2007), but was lower than for other Brazilian Amerindians (Salzano et al , 1974, 1991, 1997a,b, 1998; Oliveira et al , 1998). …”

Section: Discussionmentioning

confidence: 98%

“…Haptoglobin is one of the genetic markers used to describe the genetic constitution of populations. However, there are few data on the haptoglobin gene subtypes in the general Brazilian population, although several reports on Hp subtypes (phenotypes) and types have been published, mostly for indigenous populations (reviewed by Salzano and Callegari-Jacques, 1988; Simões et al , 1989; Salzano et al , 1991, 1997a,b, 1998; Santos et al , 1998; Beiguelman et al , 2003; Calderoni et al , 2006; Zaccariotto et al , 2006). The aim of this work was to examine the frequencies of the Hp gene subtypes in three Brazilian population groups of different ethnic origins (Kayabi Amerindians, Kalunga Afro-descendents and inhabitants of the Federal District).…”

Section: Introductionmentioning

confidence: 99%

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

et al. 2009

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Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp *2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequencies vary according to the ethnic origin of the population. The Hp*1 allele has two subtypes, Hp *1F and Hp *1S , that also vary in their frequencies among populations worldwide. In this work, we examined the distribution frequencies of haptoglobin subtypes in three Brazilian population groups of different ethnicities. The haptoglobin genotypes of Kayabi Amerindians (n = 56), Kalunga Afro-descendants (n = 70) and an urban population (n = 132) were determined by allele-specific PCR. The Hp*1F allele frequency was highest in Kalunga (29.3%) and lowest in Kayabi (2.6%). The Hp*1F/Hp*1S allele frequency ratios were 0.6, 1.0 and 0.26 for the Kayabi, Kalunga and urban populations, respectively. This variation was attributable largely to the Hp*1F allele. However, despite the large variation in Hp*1F frequencies, results of F ST (0.0291) indicated slight genetic differentiation among subpopulations of the general Brazilian population studied here. This is the first Brazilian report of variations in the Hp*1F and Hp*1S frequencies among non-Amerindian Brazilians.

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New protein genetic studies in six Amazonian Indian populations

Cited by 8 publications

References 22 publications

Genetic relationships between Amerindian populations of Argentina

Genetic relationships between Amerindian populations of Argentina

Genetic studies in French Guiana populations: Synthesis

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

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