New protein tyrosine phosphatase inhibitors from fungus Aspergillus gorakhpurensis F07ZB1707

Abstract

Twelve novel metabolites were isolated from Aspergillus gorakhpurensis F07ZB1707. Aspergorakhin A (1) showed selective activities against PTP1B and SHP1 over TCPTP with IC50 values of 0.57, 1.19, and 22.97 μM, respectively.

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

“… 73 Three nortriterpenoids aspergorakhins B–D 203 – 205 ( Figure 3F ) were obtained from Aspergillus gorakhpurensis F07ZB1707, which was fermented by a salt-containing medium. 6 Encindolenes D-H 206 – 210 ( Figure 3F ), were isolated from the fungus Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne.…”

“… 76 Aspergorakhin A 213 ( Figure 3F ) was obtained from the extract of soil-derived fungus Aspergillus gorakhpurensis F07ZB1707. 6 …”

“… 87 Aspergorakhins E–J, L ( 242 – 247, 248 ) ( Figure 4B ) were obtained from the extract of soil-derived fungus Aspergillus gorakhpurensis F07ZB1707. 6 Six new polyketide-derived oxaphenalenone dimers, talaromycesone C 249 and macrosporusones A-E 250 – 254 ( Figure 4B ), were isolated from the mycelium of the fungus Talaromyces macrosporus KKU-1NK8. 88 Four new oxaphenalenone dimers (bacillisporins I 255 and J 256 ( Figure 4B ), duclauxamides B 257 and C 258 ( Figure 4C )) were isolated from the soil fungus Talaromyces bacillisporus BCC17645.…”

“… 56 One cyclohexanone derivative aspergorakhin K 383 ( Figure 4H ) was obtained from Aspergillus gorakhpurensis F07ZB1707. 6 Yanchao Xu et al fermented Aspergillus fumigatus GZWMJZ-152 in a rice solid medium and isolated four new sulfur-containing benzophenones, sulfurasperines A−D 384 – 387 ( Figure 4H ). 128 …”

“… 5 Since Alexander Fleming discovered penicillin in 1928, fungi have become a considerable resource for novel compounds and new drugs. 6 The secondary metabolites of fungi are a rich source of small molecule compound libraries, and some metabolites have significant biological activities, 7 such as the antibacterial agent penicillins, immunosuppressive drug cyclosporin A, antifungal drug echinocandin B, and cholesterol-lowering agent lovastatin. 8 Fungi are an ideal source for obtaining novel skeletons through large-scale culture: compared with plants, fungi can proliferate rapidly from small amounts of spores to a mass of branching hyphaes, which are more environmentally friendly than collecting plant materials; compared with bacteria, fungi can be cultured in a solid medium for a longer time.…”