New Rat Model of Advanced Non-Alcoholic-Steatohepatitis-Cirrhosis Developing Acute-on-Chronic-Liver failure

Kraus, Nico; Moeslein, Magnus; Schierwagen, Robert; Ortiz, Cristina; Torres, Sandra; Tyc, Olaf; Hieber, Christoph; Meier, Caroline; Müller, Elena; Holz, F.; Gu, Wenyi; Brol, Maximilian Joseph; Zeuzem, Stefan; Uschner, FrankErhard; Trebicka, Jonel; Klein, Sabine

doi:10.1055/s-0041-1740678

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2022

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“…Interestingly, the generated ACLF was accompanied by extra-hepatic multiorgan failure. 45 Representatives of CCl 4 -dependent models are summarized in Table 1. [28][29][30]32,[45][46][47][48][49][50][51][52][53][54][55][56]…”

Section: -Based Modelsmentioning

confidence: 99%

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Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review

Hassan¹,

Li²

2022

J Clin Transl Hepatol

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Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.

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