Authors' synopsis Simultaneous measurements of the concentration of dye by a fiberoptic catheter and of the temperature by a thermistor catheter were obtained in dogs. No significant diference for cardiac output and stroke uolume was found. The slightly but significant higher residual.fraction by thermodilution than by Jiberoptic technique is caused by cold transfer between irentricular myocardium and caoity. It becomes evident after the jifth beat.Indicator dilution methods have been used t o measure ventricular volume for many years. The technique involves ventricular injection of a n indicator with measurement of its serial dilution immediately beyond the semilunar valves. Mainly cold or dye as indicators are employed (Holt, 1956;Liithy, 1962;Rapaport, Wiegand, and Bristow, 1962;Hugenholtz, Gamble, Monroe, and Polanyi, 1965; Krayenbuhl, 1969). To our knowledge n o comparison of the thermodilution versus the dye method with intravascular measurement at the same sensor site has yet been reported.Thermodilution is assumed to be complicated by heat exchange between blood and the heart wall because of temperature gradient (Rolett, Sherman, and Gorlin, 1964). The resultant cooling of the inner layers of the ventricular wall may serve as a storage of indicator which is then gradually released to the chamber as the blood temperature gradient is reversed. As a result the indicator decay slope may be prolonged.The present study was undertaken t o compare left ventricular residual fraction a n d stroke volume of simultaneously recorded aortic thermal and fiberoptic dye dilution curves and to estimate the error from heat transfer complicating the thermodilution method. For rapid sensing of the washout steps the thermistor and the fiberoptic catheters, both with similar time constants, were positioned together in the ascending aorta above the aortic valves.
MethodsExperiments were carried out in five male mongrel dogs, ranging between 2 1 and 23 kg body weight. After premedication with z mg morphine sulphate/kg body weight, the animals were anaesthetized with 90 mg/kg body weight of a-chloralose. Heparin was given in a dose of 300 i.u./kg body weight. The animals were intubated with a cuffed endotracheal tube and ventilated with air by means of an Engstrom respirator at a rate of 20 c/min. Care was taken to maintain stable normal body temperature throughout the experiment.Catheters were positioned under fluoroscopic control in the following manner: through the