An in vivo oximeter which uses as a probe a standard cardiac catheter or a Cournand needle is described. The oxygen saturation is obtained from the light intensities at two wavelengths (805 and 660 m",) diffusely reflected by the unhemolyzed blood. The light is brought to the tip of the catheter and back again to the proximal end by means of glass fibers. Details of the construction of the instrument and experimental results are given. Drabkin and Schmidt. 8 E.

It is experimentally shown that the ratio of light reflected by a nonhemolysed blood sample at two suitable wavelengths is a linear function of the oxygen saturation. A simple instrument to determine oxygen saturation in vitro, based on these findings, is described.

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Tris(2,3-dibromopropyl) phosphate (TRIS) was the most popular flame retardant chemical used in children's sleepwear. Acute toxicological data indicated that TRIS was low in toxicity. Since human exposure to TRIS-treated fabrics could occur for long periods of time, a subchronic study was undertaken to obtain additional information. The dermal application of TRIS (neat) at a dose of 1 ml/kg (2.27 g/kg) to the clipped backs of albino rabbits, once each week for 3 months, resulted in testicular atrophy and chronic interstitial nephritis in males. Females did not show any adverse effects.

A survey of over 249 detergent products involving biological testing, chemical analyses, and product label reviews has been conducted from 1971-1976 for determining compliance with the Federal Hazardous Substances Act. Test results for 145 detergent products having both chemical and biological data were examined. All of the tested detergents were rabbit eye irritants. Forty-seven per cent were also either rabbit primary skin irritants or corrosives. Eighty-one per cent were either rabbit esophageal test irritants or corrosives, and 80 per cent had rat oral toxicities 5g/kg or less.