New research highlights: Impact of chronic ingestion of white kidney beans (Phaseolus vulgaris L. var. Beldia) on small-intestinal disaccharidase activity in Wistar rats

Nciri, Nader; Cho, Namjun

doi:10.1016/j.toxrep.2017.12.016

Cited by 13 publications

(12 citation statements)

References 67 publications

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“…Dietary provocative agents such as Phytohemagglutinin (PHA), a red kidney bean lectin, and microbial protease (PT), found in dairy products such as cheese, cause precocious gut maturation characterized by a decrease in macromolecule absorptive capacity, an increase in intestinal length and acceleration of epithelial cell growth, an effect which is independent of gut bacteria . The current study by Marungruang et al .…”

Section: Gut Microbiota and The Gastrointestinal Barriermentioning

confidence: 96%

“…The maturation of the GIB depends on diet and the gut microbiota in addition to other factors (reviewed in). Dietary factors can promote the maturation of the GIB both in a microbiota dependent and independent manner . Diet has a significant effect on gut microbiota composition and function; hence, it is not surprising that post‐weaning there is an overall increase in microbial diversity (transient decrease in microbial diversity shortly after weaning followed by increase in microbial diversity over a long‐term), which in turn coincides with maturation of the GIB.…”

Section: Gut Microbiota and The Gastrointestinal Barriermentioning

confidence: 99%

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Microbiota‐gut‐brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers

Bhattarai

2018

Neurogastroenterology Motil

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The gastrointestinal barrier and the blood brain barrier represent an important line of defense to protect the underlying structures against harmful external stimuli. These host barriers are composed of epithelial and endothelial cells interconnected by tight junction proteins along with several other supporting structures. Disruption in host barrier structures has therefore been implicated in various diseases of the gastrointestinal tract and the central nervous system. While there are several factors that influence host barrier, recently there is an increasing appreciation of the role of gut microbiota and their metabolites in regulating barrier integrity. In the current issue of Neurogastroenterology and Motility, Marungruang et al. describe the effect of gastrointestinal barrier maturation on gut microbiota and the blood brain barrier adding to the growing evidence of microbiota-barrier interactions. In this mini-review I will discuss the effect of gut microbiota on host epithelial barriers and its implications for diseases associated with disrupted gut-brain axis.

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Section: Gut Microbiota and The Gastrointestinal Barriermentioning

confidence: 96%

Section: Gut Microbiota and The Gastrointestinal Barriermentioning

confidence: 99%

Microbiota‐gut‐brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers

Bhattarai

2018

Neurogastroenterology Motil

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“…In all cases, beans were either consumed raw, soaked, or cooked using temperatures inadequate to destroy PHA. Nonetheless, PHA toxin appears to be eliminated by 10 min of boiling [ 29 ]. Mechanistically, lectins and hemagglutinins are resistant to digestion by both host enzymes and bacteria, and therefore pass through the gastrointestinal tract functionally and immunologically intact.…”

Section: Lectinsmentioning

confidence: 99%

“…This change in intestinal integrity resulted in compromised nutrient absorption (protein, lipid and vitamin B12) and reduced growth of experimental animals [ 34 , 35 , 36 , 37 ]. Nciri and colleagues demonstrated that administration of 300 mg of a raw Beldia bean (white kidney bean) flour for 10 days caused intestinal alterations, distorted jejunum morphology of the microvilli, and reduced enzyme activity in mice [ 29 , 38 ]. Another proposed mechanism of PHA toxicity is intestinal dysbiosis secondary to PHA-induced intestinal damage [ 37 , 39 ].…”

Section: Lectinsmentioning

confidence: 99%

Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds

2020

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Plant-based diets are associated with reduced risk of lifestyle-induced chronic diseases. The thousands of phytochemicals they contain are implicated in cellular-based mechanisms to promote antioxidant defense and reduce inflammation. While recommendations encourage the intake of fruits and vegetables, most people fall short of their target daily intake. Despite the need to increase plant-food consumption, there have been some concerns raised about whether they are beneficial because of the various ‘anti-nutrient’ compounds they contain. Some of these anti-nutrients that have been called into question included lectins, oxalates, goitrogens, phytoestrogens, phytates, and tannins. As a result, there may be select individuals with specific health conditions who elect to decrease their plant food intake despite potential benefits. The purpose of this narrative review is to examine the science of these ‘anti-nutrients’ and weigh the evidence of whether these compounds pose an actual health threat.

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“…Although some digestive enzymes would not affect the α-AI, the pH of the hydrolysis will inevitably cause adverse influences on the α-AI activity [18]. The α-AI tends to retain its activity in the condition with pH between 3 and 7, which is suitable for some commercial proteases [16].…”

Section: Introductionmentioning

confidence: 99%

Preparation of α-Amylase Inhibitor from Seeds of White Kidney Bean Using a Novel and Scalable Process Based on Enzymatic Hydrolysis

Rang¹,

Zhao²

2019

IJNFS

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This study proposed and evaluated a novel and scalable process based on enzymatic hydrolysis for the preparation of α-amylase inhibitor (α-AI) in seeds of white kidney bean (Phaseolus vulgaris). The process mainly involved heat treatment (70°C/30 min), enzymatic hydrolysis, isoelectric precipitation and 70% ethanol precipitation. The optimal preparation parameters for enzymatic hydrolysis and isoelectric precipitation were as follows: Flavourzyme 500MG was used for enzymatic hydrolysis and the ultimate hydrolysate was obtained at 180 min, followed by isoelectric precipitation at pH 3.6. The loss of miscellaneous proteins and purification fold in the novel process were relatively low (85.84% and 4.74, respectively), while the α-AI activity yield (67.12%) was much higher than the values obtained by chromatography. Combined with the SDS-PAGE analysis, enzymatic hydrolysis proved to have modified the pI and alcohol-solubility of the miscellaneous proteins, which has a favorable influence on isoelectric precipitation and ethanol precipitation for the preparation of the α-AI.

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New research highlights: Impact of chronic ingestion of white kidney beans (Phaseolus vulgaris L. var. Beldia) on small-intestinal disaccharidase activity in Wistar rats

Abstract: Graphical abstract

Cited by 13 publications

References 67 publications

Microbiota‐gut‐brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers

Microbiota‐gut‐brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers

Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds

Preparation of α-Amylase Inhibitor from Seeds of White Kidney Bean Using a Novel and Scalable Process Based on Enzymatic Hydrolysis

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