New Results on the Synthesis of the Centrally Acting Muscle Relaxant Chlormezanone and Its Resolution on a Gram Scale Using a Chiralcel® OD Column.

Abstract

OD Column. -An improved synthesis of the title compound (V) is presented. It is noteworthy that the separation of both enantiomers is achieved on a gram scale by preparative column chromatography on a Chiracel® OD column with better than 99% e.e. -(OELSCHLAEGER*, H.; WANGE, J.; LETSCH, J.; SEELING, A.; Pharmazie 58 (2003) 2, 95-98; Inst. Pharm., Friedrich-Schiller-Univ.,