New Serum Indicator of Interstitial Pneumonitis Activity

Kohno, Nobuoki; Kyoizumi, S; Awaya, Yukikazu; Fukuhara, Hirofumi; Yamakido, Michio; Akiyama, Mitoshi

doi:10.1378/chest.96.1.68

Cited by 406 publications

(110 citation statements)

References 9 publications

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“…The gene for KL-6 belongs to the MUC1 gene family. It is mainly detected in alveolar type II and bronchiolar epithelial cells [1, 2, 3]. It is a sensitive indicator of damage to alveolar type II cells, which strongly express this mucin at their surface [1, 2].…”

Section: Introductionmentioning

confidence: 99%

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KL-6, Surfactant Protein A and D in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis

et al. 2001

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Background: KL-6, and surfactant protein A (SP-A) and surfactant protein D (SP-D) derived from alveolar type II cells and/or bronchiolar epithelial cells have been reported to be useful markers for interstitial lung diseases. Objective: The aim of this study was to measure the levels of these molecules in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis to investigate their relationship with other markers of inflammatory activity. Methods: We measured KL-6, SP-A and SP-D levels in BALF from patients with pulmonary sarcoidosis using an ELISA. Results: KL-6 and SP-D, but not SP-A levels were significantly increased in pulmonary sarcoidosis compared with controls. KL-6, SP-A and SP-D levels were significantly correlated with each other. KL-6 and SP-D levels were relatively and significantly correlated with the percentage of lymphocytes in BALF. KL-6, SP-D, but not SP-A levels were significantly correlated with the concentration of albumin in BALF. There was no significant correlation between KL-6, SP-A, or SP-D levels and chest X-ray findings, angiotensin-converting enzyme levels, or CD4/CD8 ratio in BALF. Conclusions: We conclude that KL-6 and SP-D levels in BALF were increased in pulmonary sarcoidosis. Since these markers are specifically derived from epithelial cells, it is considered that KL-6 and SP-D levels are reflecting damage or release of these markers from epithelial cells due to the inflammatory response.

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Section: Introductionmentioning

confidence: 99%

“…It is a sensitive indicator of damage to alveolar type II cells, which strongly express this mucin at their surface [1, 2]. It is thought that serum levels of KL-6 are increased in pneumonitis of various etiologies, such as idiopathic pulmonary fibrosis, radiation pneumonitis, and reflect disease activity [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

KL-6, Surfactant Protein A and D in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis

et al. 2001

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“…Furthermore, high levels of KL-6 antigen were detected in the serum of patients with lung adenocarcinoma, pancreatic cancer, breast cancer and hepatocellular cancer [1]. It was reported that KL-6 is a sensitive serum marker indicating activity of pulmonary diseases, such as idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonitis [1, 2, 3, 4, 5, 6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Clinical Usefulness of Combined Measurements of Serum Soluble Transferrin Receptor Levels and Serum Interleukin-18 Levels at Determination of Serum KL-6 Levels in Haematologic Malignancies

et al. 2000

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“…We assessed complete blood cell counts, differential white blood cell counts, the erythrocyte sedimentation rate (ESR) and the LST [4] due to Bunashimeji sporesusing peripheral blood. The results of the LST were reported as the value of the stimulation index (SI), serum Krebs von der Lungen-6 [5](KL-6; normal range: <500 units/ml), serum surfactant protein (SP)-A [6] (normal range; <43.8 ng/ml) and serum SP-D [7] (normal range: <110 ng/ml). …”

Section: Methodsmentioning

confidence: 99%

Hypersensitivity Pneumonitis due to Bunashimeji Mushrooms in the Mushroom Industry

Tsushima¹,

Yoshikawa²,

Kawakami

et al. 2005

Int Arch Allergy Immunol

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Background: Detection of hypersensitivity pneumonitis (HP) in employees involved in the Bunashimeji mushroom industry is difficult. The level of precipitating antibody is not related with the prediction of progression and resolution of HP. The aims of this study were to examine the actual prevalence of HP in the Bunashimeji industry and the clinical differences among selected employees. Methods: One hundred and fourteen employees worked in Bunashimeji enterprises. These subjects were divided into the following subgroups: office workers, pickers/packers with mask and pickers/packers without mask. We measured serum Krebs von der Lungen-6 (KL-6), surfactant protein (SP)-A and SP-D, and examined the stimulation index (SI) due to Bunashimeji spores. Chest high-resolution computed tomography (HRCT), pulmonary function tests and bronchoalveolar lavage (BAL) were performed for select employees who showed positive SI values (>200%) to examine the clinical differences. Results: The proportion of respiratory symptoms was significantly higher in the pickers/packers than that in the office workers. The picker/packer group had high serum KL-6 concentrations and SI compared with the office worker group. Thirty select employees were divided into the following three subgroups: HP, select employees without HP, and SI <400% and KL-6 <500 U/ml , using high SI levels (>400%) and positive serum KL-6 concentration (>500 U/ml). Four exhibited ground glass opacities with centrilobular fine nodules on HRCT, and 8 had high numbers of lymphocytes in the BAL fluid. The BAL findings and serum KL-6 concentrations showed significant differences among the three groups. Conclusions: Four employees were evaluated as having HP. Serum KL-6 and SP-D may be related to the resolution of HP in addition to SI and chest HRCT.

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New Serum Indicator of Interstitial Pneumonitis Activity

Cited by 406 publications

References 9 publications

KL-6, Surfactant Protein A and D in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis

KL-6, Surfactant Protein A and D in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis

Clinical Usefulness of Combined Measurements of Serum Soluble Transferrin Receptor Levels and Serum Interleukin-18 Levels at Determination of Serum KL-6 Levels in Haematologic Malignancies

Hypersensitivity Pneumonitis due to Bunashimeji Mushrooms in the Mushroom Industry

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