The Khammam Schist Belt (KSB), southeastern India, represents a part of the collision zone that is sandwiched between the Eastern Dharwar Craton to the west and the Eastern Ghats Mobile Belt (EGMB) to the east. Quartzofeldspathic gneisses of the EGMB and garnet-kyanite metapelites of the KSB have been investigated to characterize P-T-t evolution of the Khammam region. Pseudosection modeling reveals that the melt-bearing quartzofeldspathic gneiss experienced peak and post-peak metamorphism at P-T conditions of 7.9-8.1 kbar/790-810 °C and ~ 7.0 kbar/740-750 °C, respectively. In contrast, metapelite witnessed peak metamorphism at 7.4-7.8 kbar/600-640 °C, followed by post-peak retrogression at 6.1-6.6 kbar/590-625 °C. U-Th-(total) Pb monazite ages from the gneiss constrain the peak and retrograde metamorphic episodes at 1.63-1.53 Ga and 1.48-1.38 Ga, while those in the metapelites were determined at 1.25-1.20 Ga and 1.18-1.10 Ga, respectively. These P-T-t estimates indicate that the KSB, Vinjamuru, and Ongole domains evolved distinctly during Late Paleoproterozoic-Late Mesoproterozoic. The younger ages (0.90-0.81 Ga) were ascribed to the formation of the Eastern Indian Tectonic Zone, implying its extension beyond the western margin of the EGMB. Besides, the distinct Neoarchean ages (2.79-2.45 Ga) are related to the Archean protolith of the quartzofeldspathic gneisses, which were likely derived from the Archean crust of the Napier-Rayner Complex. This tectonothermal restoration is new and characterizes the Khammam region as the hot and composite collision zone with protracted geological history.