New spiro-piperidines as 5-HT2B receptor antagonists

Use of an efficient polystyrene‐supported cerium catalyst for one‐pot multicomponent synthesis of spiro‐piperidine derivatives and click reactions in green solvent

“…Various N ‐substituted piperidines are synthetic intermediates for spermidine‐nitroimidazole drugs for the treatment of A549 lung carcinoma . Due to significant biological activity and miscellaneous interesting physiological activities, spiro‐substituted piperidines have received a great deal of attention in recent years . The spiro‐piperidine nucleus is frequently found in several plant alkaloids and animal toxins and widely used in the treatment of cocaine abuse, epileptic disorder and depression, in the prevention of various inflammatory diseases, immune diseases such as autoimmune diseases or allergic diseases, and HIV infection, and in 5‐HT2B receptor antagonists .…”

“…Due to significant biological activity and miscellaneous interesting physiological activities, spiro‐substituted piperidines have received a great deal of attention in recent years . The spiro‐piperidine nucleus is frequently found in several plant alkaloids and animal toxins and widely used in the treatment of cocaine abuse, epileptic disorder and depression, in the prevention of various inflammatory diseases, immune diseases such as autoimmune diseases or allergic diseases, and HIV infection, and in 5‐HT2B receptor antagonists . Despite their great importance, to date there are only a few reports in the literature documenting the synthesis of these spiro‐substituted compounds .…”

Cerium Supported Chitosan as an Efficient and Recyclable Heterogeneous Catalyst for Sustainable Synthesis of Spiropiperidine Derivatives

“…[9][10][11][12][13][14] Recently spiro-substituted piperidines have received considerable attention due to their important pharmacological profiles like selective and potent σ receptor ligands which can be used in the treatment of cocaine abuse, depressions, and epileptic disorders and 5-HT 2B receptor antagonists. [15][16][17][18][19][20] Owing to the importance of these compounds in the field of medicine, unexpectedly, there are only few protocols available in literature documenting the synthesis of these spiro compounds. [21][22][23][24] However, many shortcomings associated with these protocols include the use of homogeneous catalysts, toxic solvents, long reaction times and very limited substrate tolerance.…”

“…The piperidine ring unit forms the core of a large family of alkaloids and natural products with strong medicinal and interesting structural properties. The presence of piperidine motifs in drug molecules has generated a lot of interest in development of efficient protocols for the synthesis of these compounds. − Recently, spiro-substituted piperidines have received considerable attention due to their important pharmacological profiles like selective and potent σ receptor ligands that can be used in the treatment of cocaine abuse, depression and epileptic disorders and 5-HT 2B receptor antagonists. − Owing to the importance of these compounds in the field of medicine, unexpectedly, there are only few protocols available in the literature documenting the synthesis of these spiro compounds. − However, many shortcomings associated with these protocols include the use of homogeneous catalysts, toxic solvents, long reaction times and very limited substrate tolerance. Therefore, it is highly desirable to develop an efficient protocol for the synthesis of spiropiperidine adducts that is highly efficient, environmental friendly, tolerates a wide range of substrates and involves the reuse of the catalyst.…”

Facile Synthesis of new 3,5‐Dispiro Substituted Piperidine Analogs via Microwave‐Assisted One Pot Multicomponent Reaction

“…Spiropiperidinyl ring systems have been isolated from various plant alkaloids and animal toxins . Moreover, spirofused piperidines have considerable attention because of their miscellaneous interesting physiological activities . Recently, only few reports on the synthesis of various 3,5‐dispiro substituted piperidines have used FeCl 3 , In(OTf) 3 , and silica tungstic acid, but unfortunately, these reports were used in conventional method for the synthesis of spiropiperidines.…”