2022
DOI: 10.1016/j.ejmech.2022.114653
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New structural classes of antimalarials

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Cited by 12 publications
(2 citation statements)
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“…The treatment of malaria is currently based on eight major classes of compounds: the 4-aminoquinolines in which we find chloroquine, piperaquine and amodiaquine, the 8-aminoquinolines in which we find primaquine and tafenoquine, the antifolates, containing pyrimethamine and proguanil, the sulfonamides, containing dapsone and sulfadoxine, the 4-amino alcohols, containing quinine, mefloquine, halofantrine, lumefantrine, the napthoquinones, containing atovaquone, the antibiotics, containing doxycycline, and the endoperoxides, containing artemisinin, artesunate, artemether, and dihydroartemisinin. However, their efficacy gradually decreases as parasites develop resistance [ 5 ]. It is urgently necessary to discover new classes of antimalarial drugs.…”
Section: Introductionmentioning
confidence: 99%
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“…The treatment of malaria is currently based on eight major classes of compounds: the 4-aminoquinolines in which we find chloroquine, piperaquine and amodiaquine, the 8-aminoquinolines in which we find primaquine and tafenoquine, the antifolates, containing pyrimethamine and proguanil, the sulfonamides, containing dapsone and sulfadoxine, the 4-amino alcohols, containing quinine, mefloquine, halofantrine, lumefantrine, the napthoquinones, containing atovaquone, the antibiotics, containing doxycycline, and the endoperoxides, containing artemisinin, artesunate, artemether, and dihydroartemisinin. However, their efficacy gradually decreases as parasites develop resistance [ 5 ]. It is urgently necessary to discover new classes of antimalarial drugs.…”
Section: Introductionmentioning
confidence: 99%
“…As more than 60% of antiparasitic therapeutic agents approved between 1981 and 2019 were unaltered natural products (10%), natural product derivatives (35%), or synthetic drugs with a natural product pharmacophore (15%) [ 6 ], and as the potential of plants for the discovery of new antimalarial drugs is widely supported by the literature, research of new compounds in plants remains a rational approach [ 5 , 6 , 7 ].…”
Section: Introductionmentioning
confidence: 99%