New susceptibility alleles associated with severe coronary artery stenosis in the Lebanese population

Abstract

Background Coronary Artery Disease (CAD) is the narrowing or blockage of the coronary arteries. It is closely associated with numerous genetics and environmental factors that have been extensively evaluated in various populations. In recent studies, severe phenotypes have been strongly linked to genetic risk factors. Methods This study investigated the association of clinical, demographic, and genetic factors with severe coronary artery stenosis phenotypes in our population composed of 1734 individuals with severe coronary stenosis (≥ 50% in coronary vessels) and comparing them to 757 controls with no evidence of stenosis on angiography. We performed generalized linear model (GLM) genome-wide association studies to evaluate three stratification models and their associations to characteristics of the clinical disease. In model 1, patients were not stratified. In model 2, patients were stratified based on presence or absence of CAD family history (FxCAD). In model 3, patients were stratified by young age of CAD onset. Results Eight SNPs (single nucleotide polymorphism) were significantly associated with severe CAD phenotypes in the various models $$\left( {p < 5 \times 10^{ - 7} } \right)$$ p < 5 × 10 - 7 , four of these SNPs were associated with severe CAD and the four others were specifically significant for young CAD patients. While these SNPs were not previously reported for association with CAD, six of them are present in genes that have already been linked to coronary disease. Conclusion In conclusion, this study presents new genetic factors associated with severe stenosis and highlights different risk factors associated with a young age at diagnosis of CAD.

Identifying health research in the era of COVID-19: A scoping review

“…For this reason, different studies published updates concerning CVDs’ prognosis and treatment in the era of COVID-19. For instance, observational studies investigated the association of clinical, demographic, and genetic factors with severe coronary artery stenosis phenotypes, namely hyperlipidemia 86 , 87 while another narrative review reported the accuracy of a new intravascular optical coherence tomography in the evaluation of stent implantation and post-stent tissue coverage. 88 Moreover, one published study documented the in-hospital discharge trends for patients with acute heart failure and highlighted the need for enlisting complete education as part of the discharge process, in addition to abidance to the guidelines in prescribing medication 89 while another study summarized common etiologies for post-orthostatic tachycardia syndrome such as infections, especially viral, pregnancy, and stress.…”

Association of PCSK6 polymorphisms with susceptibility risk of large artery atherosclerotic stroke

“…In 2021, a GWAS studies suggested that the PCSK6 snps are linked to blood lipid metabolism and in ammatory [28]. What's more an recent research found PCSK6 snps were signi cantly associated with severe coronary artery stenosis [32].The analysis of expression quantitative trait loci (eQTL) showed the rs20543 snps were associated with expression of PCSK6 in single tissue (Fig. 1a), and the carriers with rsrs20543 GG increased expression of PCSK6 in Brian-caudate.…”

Genetic Variants in PHACTR1 & LPL Mediate Restenosis Risk in Coronary Artery Patients

“… 27 Among the study population, 1394 patients from Stenosis Group, and 705 patients from Stenosis Group had genotyped data available and were included in the genetic association using PLINK. 28 Using PLINK, quality control (QC) was applied, and variants were filtered out. Sex checks were performed using PLINK and variants were excluded for having >5% missing genotyping rates and <1% MAF (minor allele frequency), and for failing HWE (Hardy-Weinberg Equilibrium) test (P > 0.05).…”