New syntheses and potential antimalarial activities of new ‘retinoid-like chalcones’

Cajachalcone: An Antimalarial Compound fromCajanus cajanLeaf Extract

“…Licochalcone A, an oxygenated chalcone (Figure 1) first isolated from roots of Chinese licorice, showed antimalarial activity in both in vitro and in vivo systems [22]. Since then, investigators have been searching for new more-potent lead molecules based on chalcone scaffolds as potential antimalarial agents [23, 24]. …”

Synthesis, growth, vibrational spectral investigations and structure–property relationship of an organic NLO crystal: 3,4-Dimethoxy chalcone

“…Patil et.al [10] has reported the synthesis and second harmonic generation efficiency of 3-Br-4'-methoxychalcone where this crystal has been characterized by X-ray powder diffraction (XRD), laser damage threshold and UV-vis-NIR studies. In addition to the nonlinear optical properties, chalcones are associated with different biological activities like insecticidal [11], anticancer [12], anti-inflammatory [13], bactericidal [14], Fungicidal [15], antiviral [16], antitumor [17], antimalarial [18] and antiulcer [19].…”

Synthesis, Spectroscopic Investigations, Quantum Chemical Studies (<i>Ab-initio</i> & DFT) and Antimicrobial Activities of 3-(3-Chloro-4,5-dimethoxy-phenyl)-1-(4, 5-dimethoxy-2-methyl-Phenyl) prop-2-en-1-one

“…Chalcones are also key precursors in the synthesis of many biologically important heterocycles such as benzothiazepine, pyrazolines, 1,4diketones and flavones. Chalcones, belonging to flavonoid family, synthesized or the natural one, displayed many interesting properties including antimalarial [1,2], anticancer [3,4], antiviral [5], antibacterial [6], antifungal [7], antihyperglycemic [8] and photocytotoxicity [9] activities. In the chemical structure, three-carbon α -β unsaturated carbonyl system, the back bone of the open chain flavonoids, joins two aromatic rings.…”