New target DDR1: A “double-edged sword” in solid tumors

Tian, Yaru; Bai, Feihu; Zhang, Dekui

doi:10.1016/j.bbcan.2022.188829

Cited by 10 publications

(4 citation statements)

References 191 publications

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“…Cancer is one of the most deadly diseases that seriously threaten global health. [ 134 ] Therefore, it is extremely important to find a method that can perform early cancer diagnosis. Alpha‐fetoprotein (AFP) has been widely used as an important protein biomarker for the diagnosis of various malignancies.…”

Section: D Biomass‐derived Carbon In Electrochemical Biosensor Applic...mentioning

confidence: 99%

3D Biomass‐Derived Carbon Materials for Electrochemical Biosensors

Li,

Zhou,

Xiao

et al. 2023

Adv Materials Technologies

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Abstract3D biomass‐derived carbon (3D‐BC) materials are widely developed for various electrochemical sensors due to their structural diversity and high electrical conductivity, and are gradually experiencing their most prosperous moment. A timely and comprehensive review of structure‐strategy‐property will greatly broaden this research field. In this paper, the mechanism of biomass‐derived carbon conversion is presented and the recent progress of 3D‐BC materials for constructing high‐performance electrochemical sensors, including biomass sources, carbonization methods, and synthesis strategies for 3D‐BC is summarized, as well as their applications in different electrochemical sensors are reviewed. Finally, the challenges and opportunities for the future development of biomass‐derived carbon (BC) materials are emphasized. In conclusion, this review will assist researchers in selecting suitable precursors and strategies to design BC materials and facilitate their application in future electrochemical sensors.

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Section: D Biomass‐derived Carbon In Electrochemical Biosensor Applic...mentioning

confidence: 99%

3D Biomass‐Derived Carbon Materials for Electrochemical Biosensors

Li,

Zhou,

Xiao

et al. 2023

Adv Materials Technologies

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“…[4,5] Additionally, many new biological pathways and biomolecules are being discovered as druggable targets, supporting continuous medicinal chemistry efforts to develop novel chemotherapeutic agents. [6][7][8] Natural products have served as a reliable class of compounds for drug discovery. It has been reported that around 59 % of therapeutic agents used as anticancer drugs are either natural products or derivatives of natural products.…”

Section: Introductionmentioning

confidence: 99%

“…Adverse side effects are also a concern, causing close to 50 % of existing anticancer drugs to be withdrawn and 17 % to fail during phase 3 clinical trials [4,5] . Additionally, many new biological pathways and biomolecules are being discovered as druggable targets, supporting continuous medicinal chemistry efforts to develop novel chemotherapeutic agents [6–8] …”

Section: Introductionmentioning

confidence: 99%

Chemical Derivatization Leads to the Discovery Of Novel Analogs of Azotochelin, a Natural Siderophore, as Promising Anticancer Agents

Karadkhelkar,

Gupta,

Barasa

et al. 2024

ChemMedChem

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Siderophores are structurally unique medicinal natural products and exhibit considerable therapeutic potential. Herein, we report the design and synthesis of azotochelin, a natural siderophore, and an extensive library of azotochelin analogs as a potential anticancer agent. We modified the carboxylic acid and the aromatic ring motifs of azotochelin using various chemical motifs. We tested the compounds against six different cancer cell lines (KB‐3‐1, SNB‐19, MCF‐7, K‐562, SW‐620, and NCI‐H460) and a non‐cancerous cell line (HEK‐293) to assess the cytotoxicity. Among the twenty compounds tested, the IC50 values of eight compounds (14, 32, 35‐40, and 54) were between 0.7 to 2.0 μM against a lung cancer cell line (NCI‐H460). Moreover, several compounds had a good cytotoxicity profile (IC50 < 10 μM) against many tested cancer cell lines. The flow cytometry analysis showed that compounds 36 and 38 induce apoptosis in NCI‐H460 in a dose‐dependent manner. The cell cycle analysis indicated that compounds 36 and 38 significantly arrest the cell cycle at the S phase to block cancer cell proliferation in the NCI‐H460 cell line. The study has produced various novel azotochelin analogs that are potentially effective anticancer agents and leads for further synthetic and medicinal chemistry exploration.

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“…Discoidin domain receptor 1 (DDR1), a tyrosine kinase receptor, has been found to function as a sensor for the extracellular matrix (ECM) by regulating several cell functions, such as migration, adhesion, proliferation, cytokine secretion, and ECM homeostasis/remodeling. DDR is mostly expressed in epithelial cells, and its phosphorylation via collagen binding leads to the activation of various signaling pathways such as MAPK, integrin or Notch (reviewed in [6][7][8]). Nonetheless, several studies have suggested that DDR1 also exhibits collagen-independent activities [9].…”

Section: Introductionmentioning

confidence: 99%

Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma

Maitz,

Valadez-Cosmes,

Raftopoulou

et al. 2023

Cancers

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Lung cancer is the leading cause of cancer-related death worldwide. Discoidin domain receptor 1 (DDR1), a tyrosine kinase receptor, has been associated with poor prognosis in patients with non-small cell lung cancer (NSCLC). However, its role in tumorigenesis remains poorly understood. This work aimed to explore the impact of DDR1 expression on immune cell infiltration in lung adenocarcinoma. Pharmacological inhibition and knockout of DDR1 were used in an immunocompetent mouse model of KRAS/p53-driven lung adenocarcinoma (LUAD). Tumor cells were engrafted subcutaneously, after which tumors were harvested for investigation of immune cell composition via flow cytometry. The Cancer Genome Atlas (TCGA) cohort was used to perform gene expression analysis of 509 patients with LUAD. Pharmacological inhibition and knockout of DDR1 increased the tumor burden, with DDR1 knockout tumors showing a decrease in CD8+ cytotoxic T cells and an increase in CD4+ helper T cells and regulatory T cells. TCGA analysis revealed that low-DDR1-expressing tumors showed higher FoxP3 (regulatory T-cell marker) expression than high-DDR1-expressing tumors. Our study showed that under certain conditions, the inhibition of DDR1, a potential therapeutic target in cancer treatment, might have negative effects, such as inducing a pro-tumorigenic tumor microenvironment. As such, further investigations are necessary.

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New target DDR1: A “double-edged sword” in solid tumors

Cited by 10 publications

References 191 publications

3D Biomass‐Derived Carbon Materials for Electrochemical Biosensors

3D Biomass‐Derived Carbon Materials for Electrochemical Biosensors

Chemical Derivatization Leads to the Discovery Of Novel Analogs of Azotochelin, a Natural Siderophore, as Promising Anticancer Agents

Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma

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