New Taxane Diterpenoids from Taxus yunnanensis

Hai, Ping; Wen, Shi-Zhen; Li, Yan; Gao, Yuan; Jiang, Xian‐Jun; Wang, Fei

doi:10.1007/s13659-014-0003-9

Cited by 14 publications

(9 citation statements)

References 16 publications

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“…Recently, novel taxoids have been isolated from different Taxus species. For example, taxezopidine J and taxuspine D from the seeds of T. cuspidata , a new taxane glucoside from the bark of T. mairei , two new rearranged taxane diterpenoids from the barks of T. wallichiana , and three new taxane diterpenoids, namely baccatin VIII, IX and X, from the seeds of T. yunnanensis were identified over the last two decades [ 16 – 19 ]. Interestingly, intermediate oxygenation steps produce a broad range of taxusin-like metabolites, which are considered as dead-end metabolites and cannot be used for Taxol biosynthesis [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas

Luo

Zhan

et al. 2018

BMC Plant Biol

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BackgroundPlants of the genus Taxus have attracted much attention owing to the natural product taxol, a successful anti-cancer drug. T. fuana and T. yunnanensis are two endangered Taxus species mainly distributed in the Himalayas. In our study, an untargeted metabolomics approach integrated with a targeted UPLC-MS/MS method was applied to examine the metabolic variations between these two Taxus species growing in different environments.ResultsThe level of taxol in T. yunnanensis is much higher than that in T. fuana, indicating a higher economic value of T. yunnanensis for taxol production. A series of specific metabolites, including precursors, intermediates, competitors of taxol, were identified. All the identified intermediates are predominantly accumulated in T. yunnanensis than T. fuana, giving a reasonable explanation for the higher accumulation of taxol in T. yunnanensis. Taxusin and its analogues are highly accumulated in T. fuana, which may consume limited intermediates and block the metabolic flow towards taxol. The contents of total flavonoids and a majority of tested individual flavonoids are significantly accumulated in T. fuana than T. yunnanensis, indicating a stronger environmental adaptiveness of T. fuana.ConclusionsSystemic metabolic profiling may provide valuable information for the comprehensive industrial utilization of the germplasm resources of these two endangered Taxus species growing in different environments.Electronic supplementary materialThe online version of this article (10.1186/s12870-018-1412-4) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas

Luo

Zhan

et al. 2018

BMC Plant Biol

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“…Taxus yunnanensis is one of six Taxus species in China (Zhang et al, 2012) that is mainly distributed in the southwest region (Fu et al, 1999). This species is a patchily distributed, understory woody gymnosperm that has an extremely high medicinal value because of the presence of taxol and heteropolysaccharides, which are natural anti-cancer substances that are effective for treatment of ovarian, breast and liver cancers (Yin et al, 2010;Hai et al, 2014). In China, a number of natural T. yunnanensis populations have been led to smaller and more isolated populations because of natural habitat fragmentation caused by excessive anthropogenic logging for taxol extraction (Miao et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Low genetic diversity in the endangeredTaxus yunnanensisfollowing a population bottleneck, a low effective population size and increased inbreeding

Miao

Zhang

2016

Silvae Genetica

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Taxus yunnanensis, which is an endangered tree that is considered valuable because it contains the effective natural anticancer metabolite taxol and heteropolysaccharides, has long suffered from severe habitat fragmentation. In this study, the levels of genetic diversity in two populations of 136 individuals were analyzed based on eleven polymorphic microsatellite loci. Our results suggested that these two populations were characterized by low genetic diversity (NE = 2.303/2.557; HO = 0.168/0.142; HE = 0.453/0.517), a population bottleneck, a low effective population size (Ne = 7/9), a high level of inbreeding (FIS = 0.596/0.702), and a weak, but significant spatial genetic structure (Sp = 0.001, b = −0.001*). Habitat fragmentation, seed shadow overlap and limited seed and pollen dispersal and potential selfing may have contributed to the observed gene tic structure. The results of the present study will enable development of practical conservation measures to effectively conserve the valuable genetic resources of this endangered plant.

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“…The yew tree is an extremely toxic plant that also has medicinal properties such as an anti-cancer drug, possibly due to the presence of taxol and/or diterpenes (Hai et al 2014;Qu and Chen 2014). All parts of the plant, except the fleshy fruit, are antispasmodic, cardiotonic, diaphoretic, emmenagogue, expectorant, narcotic and purgative (Hao et al 2012).…”

Section: Taxusmentioning

confidence: 99%

Allelopathic Potential of Select Gymnospermous Trees

Teixeira¹,

Karimi²,

Mohsenzadeh³

et al. 2015

Journal of Forest and Environmental Science

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Allelopathy is an ecological phenomenon that refers to the beneficial or harmful effects of one plant on another plant, both crop and weed species, by the release of organic chemicals (allelochemicals) from plant parts by leaching, root exudation, volatilization, residue decomposition in soil and other processes in both natural and agricultural systems. Allelopathy can affect many aspects of plant ecology including occurrence, growth, plant succession, the structure of plant communities, survival, dominance, diversity, and plant productivity. In this review, we describe the concept of allelopathy, some mechanisms of operation within plants and then focus on a select number of gymnospermous tree genera: Ephedra, Pinus, Taxus, Cedrus, Juniperus, Picea, Cunninghamia and Araucaria. Pinus, Taxus (yew) and Cedrus (cedar) trees have a strong negative allelopathic effect on the germination, growth, or development of other plant species in the forest community.

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New Taxane Diterpenoids from Taxus yunnanensis

Cited by 14 publications

References 16 publications

Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas

Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas

Low genetic diversity in the endangeredTaxus yunnanensisfollowing a population bottleneck, a low effective population size and increased inbreeding

Allelopathic Potential of Select Gymnospermous Trees

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