New treatment modalities for granuloma faciale

Ludwig, Elisabeth; Allam, Jean Pierre; Bieber, Thomas; Novak, Natalija

doi:10.1046/j.1365-2133.2003.05550.x

Cited by 51 publications

(72 citation statements)

References 25 publications

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“…1 Despite its benign nature, the condition tends to be persistent, can be cosmetically distressing and is notoriously difficult to eradicate completely. 2 We report a case of successful treatment of granuloma faciale using 595-nm pulsed dye laser following topical mometasone and tacrolimus.…”

Section: Introductionmentioning

confidence: 99%

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Complete Clearance of Resistant Granuloma Faciale With Pulsed Dye Laser After Pre-treatment With Mometasone and Tacrolimus

Micallef

Boffa

2017

J Lasers Med Sci

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IntroductionGranuloma faciale is an uncommon, idiopathic, inflammatory dermatosis that usually affects the face.1 Despite its benign nature, the condition tends to be persistent, can be cosmetically distressing and is notoriously difficult to eradicate completely. 2 We report a case of successful treatment of granuloma faciale using 595-nm pulsed dye laser following topical mometasone and tacrolimus. Case PresentationA 39-year-old English lady with Fitzpatrick skin phototype II, presented to our Dermatology Department with 3 sharply-demarcated, reddish-brown, indurated plaques with accentuated follicular openings and few superficial telangiectases. These were present on both cheeks and the tip of the nose. The patient had been previously diagnosed with granuloma faciale in the United Kingdom 6 months previously and was started on dapsone 50 mg daily, to which there was no visible response. The patient then moved to Malta where dapsone was stopped and the lesion on the right cheek biopsied. The biopsy showed a dense neutrophilic and eosinophilic infiltrate within the papillary and reticular dermis, with a prominent Grenz zone, confirming the diagnosis of granuloma faciale. At this point, treatment with pulsed dye laser was attempted. A test area in the right cheek lesion underwent two treatments with a ScleroPlus pulsed dye laser (Candela Corporation, Wayland, Mass) with cryogenspray dynamic cooling. A wavelength of 595 nm and pulse duration of 1.5 ms were used, with a 7 mm spot at a fluence of 8.5 J/cm 2 for the first session and 9.5 J/ cm 2 for the second session, carried out after an interval of 8 weeks. There was no visible improvement with this treatment. The patient was lost to follow-up but re-presented 5 years later with the same lesions, which by then had become more prominent. She was prescribed mometasone 0.1% ointment once daily for 2 months, with no visible improvement. Tacrolimus 0.1% ointment twice daily was then added to the mometasone ointment for another 2 Case Report Abstract Introduction: Granuloma faciale is an uncommon inflammatory dermatosis which usually affects the face and is often resistant to treatment. Case Report: A 39-year-old English lady with Fitzpatrick skin phototype II presented with typical lesions of granuloma faciale, confirmed on biopsy, on her cheeks and nose. Treatment with ScleroPlus pulsed dye laser (Candela Corporation, Wayland, Mass) produced no visible improvement. The patient re-presented 5 years later with the same lesions, now more prominent. No improvement was noted with topical mometasone, however addition of topical tacrolimus caused significant flattening. Since the erythema and telangiectases persisted, treatment with ScleroPlus pulsed dye laser was re-attempted. Treatments were performed with a wavelength of 595 nm, pulse duration of 1.5 ms and 7 mm spot at a fluence of 8.5 J/cm2 in the first session and 9.5 J/cm 2 in the subsequent 2 sessions. This resulted in complete resolution without scarring or pigmentary change. There was no recurrence at follow-up ...

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Section: Introductionmentioning

confidence: 99%

“…2 We report a case of successful treatment of granuloma faciale using 595-nm pulsed dye laser following topical mometasone and tacrolimus. …”

mentioning

confidence: 99%

Complete Clearance of Resistant Granuloma Faciale With Pulsed Dye Laser After Pre-treatment With Mometasone and Tacrolimus

Micallef

Boffa

2017

J Lasers Med Sci

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“…1 Foi descrito pela primeira vez em 1945 por Wigley como um "granuloma eosinofilico cutâneo" e posteriormente, em 1952, por Pinkus, como uma "granuloma facial". 2 De etiologia ainda obscura o granuloma facial parece ser mediado por imunocomplexos. Sabe-se que alguns fatores podem favorecer esta patologia, radiação, trauma, alergia e reação Arthus-like, 3 outros podem exacerbá-la: exposição ao sol e calor.…”

Section: Introductionunclassified

Dermatoscopia no Granuloma Facial: Relato de 2 Casos

Gatti¹,

Prohmann²,

David³

et al. 2018

SPDV

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do Rio Preto (FAMERP), Ribeirão Preto, Brasil RESUMO -O granuloma facial é uma patologia cutânea rara, idiopática e benigna, com predomínio em homens caucasianos entre a terceira e quinta décadas de vida. Caracteriza-se histologicamente por um infiltrado inflamatório misto, em que fenômenos de vasculite e fibrose se associam, com predomínio na face, de curso crônico e lentamente progressivo. O diagnóstico baseia-se na história clinica, exame físico e histopatológico, com recente destaque para a dermatoscopia, que revela aspectos que podem possibilitar uma diferenciação inicial com outros diagnósticos (sarcoidose, lúpus eritematoso cutâneo, dentre outros). Existem várias opções terapêuticas propostas, porém com resultados pouco satisfatórios. Neste trabalho, relatamos dois casos de pacientes com lesões eritematosas faciais em que a dermatoscopia teve grande valor como ferramenta diagnóstica. O uso dessa modalidade deve crescer nos próximos anos em relação à essa patologia, já que, além de fornecer características importantes da doença, consiste em uma maneira simples e fácil de identificar o granuloma facial. PALAVRAS-CHAVE -Dermoscopia; Diagnóstico Diferencial; Granuloma Eosinofílico; Dermatoses Faciais. Dermoscopy of Granuloma INTRODUÇÃOO granuloma facial é uma patologia cutânea rara, idiopática e benigna, com predomínio em homens caucasianos entre a terceira e quinta décadas de vida.1 Foi descrito pela primeira vez em 1945 por Wigley como um "granuloma eosinofilico cutâneo" e posteriormente, em 1952, por Pinkus, como uma "granuloma facial". 2De etiologia ainda obscura o granuloma facial parece ser mediado por imunocomplexos. Sabe-se que alguns fatores podem favorecer esta patologia, radiação, trauma, alergia e reação Arthus-like, 3 outros podem exacerbá-la: exposição ao sol e calor.4 Sua fisiopatologia. As lesões com predomínio na face, têm curso crônico e lentamente progressivo e podem manifestar-se por pápulas, placas ou nódulos, solitários ou múltiplos, que não tendem a ulcerar e cuja coloração varia de vermelho a violeta (lesões castanho-avermelhadas). A apresentação mais comum é uma placa solitária em asa nasal (30%). O envolvimento extra-facial é raro, mas pode ocorrer, como já foi relatado, em dorso, membros superiores, região torácica, ombros e

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“…Granuloma faciale (GF) is an uncommon inflammatory dermatosis that is characterized by one or several asymptomatic brown red nodules or plaques on the face and polymorphous dense dermal infiltrates with vascular damage [1,2]. GF is known to be extremely resistant to treatment, although some cases may resolve spontaneously.…”

Section: Introductionmentioning

confidence: 99%

“…GF is known to be extremely resistant to treatment, although some cases may resolve spontaneously. Various treatments have been attempted, including topical or intralesional or systemic corticosteroids, dapsone, antimalarials, colchicine, topical tacrolimus, topical psoralen in combination with ultraviolet A (PUVA), and argon and CO 2 laser and surgical procedures [2][3][4]; however, none of these have been found to be reliably efficacious. Although GF is also known to take a long time to heal, few studies have reported the chronology of GF.…”

Section: Introductionmentioning

confidence: 99%