New triterpene isovanniloyl and antibacterial activity of constituents from the roots of Paullinia pinnata Linn (Sapindaceae)

A Novel Triterpene from the Roots of Paullinia pinnata: 6α-(3′-methoxy-4′-hydroxybenzoyl)-lup-20(29)-ene-3-one

“…The 13 C and DEPT-135 NMR spectra showed signals indicating the presence of a 30-carbon triterpene skeleton (Table 1). These data together with the 1 H NMR spectrum were in good agreement with the assignment of the lupane triterpene skeleton which was previously identified from the plant (1)(2)(3)(4)(5). In addition to the triterpene skeleton, the 13 C NMR data showed signals for seven deshielded (>  120) carbons (one carbonyl, 3 quaternary and 3 methine groups) and one methoxyl group ( Table 1) a trisubstituted aromatic ring system which, together with the methoxyl ( 3.94) and hydroxyl ( 6.01) functional groups, suggest either a vanilloyl or a isovanilloyl structure.…”

“…The use of the plant for treating infections was also validated by the work of Annan et al [3d] that reported the antimicrobial and antibacterial-resistant modifying activity of the root extract. As part of studies on the search for active principles responsible for the traditional uses of the plant, Lasisi et al [4] isolated two known (1, 2) and a novel 3-O-isovaniolloyl lupene (3) derivatives ( Figure 1). Furthermore, the novel compound 3 was shown to have good antibacterial effect when tested against a range of Gram-positive and Gram-negative bacterial test species [4].…”

“…As part of studies on the search for active principles responsible for the traditional uses of the plant, Lasisi et al [4] isolated two known (1, 2) and a novel 3-O-isovaniolloyl lupene (3) derivatives ( Figure 1). Furthermore, the novel compound 3 was shown to have good antibacterial effect when tested against a range of Gram-positive and Gram-negative bacterial test species [4]. Another study by Annan et al [5a] also examined the root extract of the plant and identified two novel 6-O--3-methoxy-4-hydroxybenzoyl derivatives of lupene (4, 5, Figure 1) that displayed significant fibroblast proliferative activities.…”

A Hydroalcoholic Extract from Paullinia pinnata L. Roots Exerts Anthelmintic Activity against Free-Living and Parasitic Nematodes

“…Except for one study showing vasorelaxant effects of a methanolic extract from the leaves and roots of P. pinnata and dealing with the presence of tannins and flavonoids as the major compounds [16], the majority of published data on P. pinnata focus on the more lipophilic constituents. Most of the compounds previously isolated from the roots belong to the group of lupane-type triterpenoids [17][18][19] and were shown to possess fibroblast stimulatory [17] as well as moderate antibacterial activities [19]. Further, friedelin, β-sitosterol, and β-sitosterolglucoside have been isolated from the leaves [20] and roots [21], and the composition of fatty acids has been determined [21].…”

LC-MS Analysis, 15-Lipoxygenase Inhibition, Cytotoxicity, and Genotoxicity of Dissotis multiflora (Sm) Triana (Melastomataceae) and Paullinia pinnata Linn (Sapindaceae)

“…Paullinia pinnata Linn from the Sapindaceae family is used for the treatment of wounds and other skin diseases, typhoid, syphilis, gonorrhea, stomachache, waist pain, and diarrhea [12]. Modern pharmacology research has indicated that the different parts of P. pinnata possesses antioxidant, antidiarrheal, antityphoid, antibacterial, wound healing, cytoprotective, anti-inflammatory, and anxiolytic activities [13][14][15][16][17][18][19]. Phytochemical studies of P. pinnata revealed the presence of secondary metabolites while numerous phenolic compounds with biological activities have been isolated [20][21][22][23][24].…”