New triterpene saponins from the seed cake of Camellia Oleifera and their cytotoxic activity

Zhou, Hao; Wang, Cheng Zhang; Ye, Jian Zhong; Chen, Hong Xia

doi:10.1016/j.phytol.2014.01.006

Cited by 40 publications

(28 citation statements)

References 18 publications

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“…These results could be explained by the negative effect of tea saponin on the activity of Saccharomyces cerevisiae. Some researchers have found that a high concentration of tea saponin induces cytotoxicity in microorganisms and bacteria Zhou et al 2014). Therefore, SSF with the addition of TSC at 10 g/L could improve enzymatic hydrolysis and the overall ethanol yield.…”

Section: Effect Of Tsc Dosage On Ethanol Productionmentioning

confidence: 99%

Enhancement of Bioethanol Production Using a Blend of Furfural Production Residue and Tea-seed Cake

Zheng¹,

Xing²,

Zhou³

et al. 2016

BioResources

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The price of raw material, energy demand in the pretreatment step, and enzyme usage rate are the major cost factors in the process of converting biomass to bioethanol. Unwashed furfural residues (FRs) possess great potential for application in bioethanol production. Surfactant addition is an effective method to enhance the fermentation rate. In this study, unwashed FRs were used directly as raw materials to produce bioethanol. Tea-seed cake (TSC), tea seed residues that contained protein and saponin, was added in the simultaneous saccharification and fermentation (SSF) process. The effect of TSC dosage on SSF was compared. TSC was added at the dosage of 10 g/L, which resulted in a final ethanol yield of 87.2%. However, a high concentration of TSC could induce cytotoxicity in yeast. The surface tension (approximately 33.92 mM/m) at SSF using TSC-medium was much lower than that of other fermentation systems (about 64.67 mN/m). Further contact angle testing showed that TSC-medium (21.7°) had better wetting capacity than FRs (45.6°). This study provided a proposed process strategy that SSF with the addition of TSC could be a minimum consumption of chemicals and enzymes for future cellulosic ethanol production process.

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Section: Effect Of Tsc Dosage On Ethanol Productionmentioning

confidence: 99%

Enhancement of Bioethanol Production Using a Blend of Furfural Production Residue and Tea-seed Cake

Zheng¹,

Xing²,

Zhou³

et al. 2016

BioResources

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“…Camellia oleifera was named for its seeds with plentiful edible oil. Tea seed pomace—the byproduct of oil manufacture—contains about 8% saponins, which have historically been wasted without full use [ 6 ]. In recent years, some research works concerning the extraction, structures, and activity identification of saponins obtained from Camellia oleifera seed have been published.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, some research works concerning the extraction, structures, and activity identification of saponins obtained from Camellia oleifera seed have been published. There are 11 novel triterpenoid saponin compounds obtained from Camellia oleifera seed [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Meanwhile, their cell protective activity [ 14 ], antioxidant activity [ 10 , 15 ], anti-fungal activity [ 16 , 17 ], cytotoxic activity [ 11 , 12 , 13 , 18 ] have been reported, indicating that the different activities depend on the different compound structures.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Hypoglycemic Activity of Triterpenoid Saponins from Camellia oleifera Abel. Seed Pomace

Yang

et al. 2017

Molecules

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One new and three known triterpenoid saponins were isolated and identified from Camellia oleifera seeds through IR, NMR, HR-ESI-MS and GC-MS spectroscopic methods, namely oleiferasaponin A3, oleiferasaponin A1, camelliasaponin B1, and camelliasaponin B2. The structure of oleiferasaponin A3 was elucidated as 16α-hydroxy-21β-O-angeloyl-22α-O-cinnamoyl-23α-aldehyde-28-dihydroxymethylene-olean-12-ene-3β-O-[β-d-galactopyranosyl-(1→2)]-[β-d-xylopyranosyl-(1→2)-β-d-galactopyranosyl-(1→3)]-β-d-gluco-pyranosiduronic acid. Camelliasaponin B1 and camelliasaponin B2 exhibited potent cytotoxic activity on three human tumour cell lines (human lung tumour cells (A549), human liver tumour cells (HepG2), cervical tumour cells (Hela)). The hypoglycemic activity of oleiferasaponin A1 was testified by protecting pancreatic β-cell lines from high-glucose damage.

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“…Considering of rich bioactive substances in the seed shell and oil cake, much attention has been paid to valorization of these byproducts [3, 5]. However, the use of TOFH is very limited, though it accounts for ~75% of these total byproducts [6].…”

Section: Introductionmentioning

confidence: 99%

“…However, the use of TOFH is very limited, though it accounts for ~75% of these total byproducts [6]. As a natural lignocellulosic biomass, the TOFH consists of 12‒14% cellulose, 19‒21% hemicellulose, and 26‒27% lignin, in addition to the rich bioactive substances (i.e., tea saponin and tannin) [5, 7]. Attempts have been made to process C. oleifera Abel hull into diverse bioproducts using a two-stage solvent-based process, which includes one aqueous ethanol organosolv (AEO) extraction step, followed by an atmospheric glycerol organosolv (AGO) pretreatment [7].…”

Section: Introductionmentioning

confidence: 99%

Bioprocessing of tea oil fruit hull with acetic acid organosolv pretreatment in combination with alkaline H2O2

Tang

Liu²,

Sun

et al. 2017

Biotechnol Biofuels

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BackgroundAs a natural renewable biomass, the tea oil fruit hull (TOFH) mainly consists of lignocellulose, together with some bioactive substances. Our earlier work constructed a two-stage solvent-based process, including one aqueous ethanol organosolv extraction and an atmospheric glycerol organosolv (AGO) pretreatment, for bioprocessing of the TOFH into diverse bioproducts. However, the AGO pretreatment is not as selective as expected in removing the lignin from TOFH, resulting in the limited delignification and simultaneously high cellulose loss.ResultsIn this study, acetic acid organosolv (AAO) pretreatment was optimized with experimental design to fractionate the TOFH selectively. Alkaline hydrogen peroxide (AHP) pretreatment was used for further delignification. Results indicate that the AAO–AHP pretreatment had an extremely good selectivity at component fractionation, resulting in 92% delignification and 88% hemicellulose removal, with 87% cellulose retention. The pretreated substrate presented a remarkable enzymatic hydrolysis of 85% for 48 h at a low cellulase loading of 3 FPU/g dry mass. The hydrolyzability was correlated with the composition and structure of substrates by using scanning electron microscopy, confocal laser scanning microscopy, and X-ray diffraction.ConclusionThe mild AAO–AHP pretreatment is an environmentally benign and advantageous scheme for biorefinery of the agroforestry biomass into value-added bioproducts.Electronic supplementary materialThe online version of this article (doi:10.1186/s13068-017-0777-1) contains supplementary material, which is available to authorized users.

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New triterpene saponins from the seed cake of Camellia Oleifera and their cytotoxic activity

Cited by 40 publications

References 18 publications

Enhancement of Bioethanol Production Using a Blend of Furfural Production Residue and Tea-seed Cake

Enhancement of Bioethanol Production Using a Blend of Furfural Production Residue and Tea-seed Cake

Cytotoxic and Hypoglycemic Activity of Triterpenoid Saponins from Camellia oleifera Abel. Seed Pomace

Bioprocessing of tea oil fruit hull with acetic acid organosolv pretreatment in combination with alkaline H2O2

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