New triterpenoids from Arisaema jacquemontii

Jeelani, Salika; Khuroo, Mohammad Akbar; Razadan, T K

doi:10.1080/10286020903505057

Cited by 14 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antioxidant activities of extracts were evaluated using DPPH free radical scavenging assay, total reducing power and total antioxidant capacity assays. The reported DPPH quenching potential of EtOH extract of A. jaquamontii was significantly ( P < 0.05) higher than reported earlier [7, 10]. Other extracts also showed significant DPPH based free radical scavenging activity.…”

Section: Discussioncontrasting

confidence: 54%

“…It is a deciduous perennial herb that grows to a height of about 1–2 m [6] and is further distributed in many parts of East Asia, Afghanistan to South East Tibet, upper and lower alpine zones in the dried areas of Himalayas. Various constituents of this plant, especially tuber lectins are being used for medicinal purposes [7]. A tuber lectin purified from this plant has been reported to exhibit potent anti-insect and anti-proliferative activities [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phytochemical, in-vitro biological and chemo-preventive profiling of Arisaema jacquemontii Blume tuber extracts

Tabassum

Zia

Blanco

et al. 2019

BMC Complement Altern Med

View full text Add to dashboard Cite

Background Arisaema jacquemontii is traditionally used in treatment of different diseases. In this study, phytochemical, in vitro biological and chemo-preventive screening of A. jacquemontii was carried out to explore its pharmacological potential. Methods The dried tuber of A. jacquemontii was extracted in 11 organic solvent mixture of different polarity. The extracts were screened for phytochemical assays (phenolics and flavonoids), antioxidants potential (free radical scavenging activity, total antioxidant activity, reducing power), biological activities (antibacterial, antifungal, cytotoxic, antileishmanial, protein kinase inhibition), and chemopreventive activities using different cell lines through standard protocols. Results Significant amount phenolic contents were determined in EtOH and MeOH extracts (210.3 ± 3.05 and 193.2 ± 3.15 μg GAE/mg, respectively). Maximum flavonoid content was determined in MeOH extract (22.4 ± 4.04 μg QE/mg). Noteworthy, DPPH scavenging activity was also recorded for MeOH extract (87.66%) followed by MeOH+EtOAc extract (85.11%). Considerable antioxidant capacity (7.8 ± 0.12 μg AAE/mg) and reducing power (3.1 ± 0.15 μg AAE/mg) was observed in extract of MeOH. The LC50 against brine shrimp and leishmanial parasite was found 9.01 and 12.87 μg/mL for n-Hex and CHCl3 extracts, respectively. The highest zone of inhibition against Streptomyces hyphae formation (12.5 ± 1.77 mm) by n-Hex extract. Growth zone of inhibition 13.8 ± 1.08 mm was recorded for EtOAc and MeOH extracts, respectively against Micrococcus luteus while 10.0 ± 0.11 mm for MeOH extract against Aspergillus flavus. In-vitro cytotoxic assay showed that n-Hex extract had higher cytotoxicity against DU-145 prostate cancer and HL-60 cancer cell lines. NF-kB and MTP potential showed 34.01 and 44.87 μg/mL for n-Hex and CHCl3 extracts, respectively in chemo-preventive potential. Conclusion The study concludes that Arisaema jacquemontii bears significant phytochemical activity and pharmacological activities, this plant can be further explored for isolation of active component against a number of aliments.

show abstract

Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Phytochemical, in-vitro biological and chemo-preventive profiling of Arisaema jacquemontii Blume tuber extracts

Tabassum

Zia

Blanco

et al. 2019

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…The tested phytoconstituents chemical structures were collected from the literature (Scifinder, Pubmed, Google Scholar). [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]…”

Section: Methodsmentioning

confidence: 99%

IN- SILICO DISCOVERY OF NATURAL LEAD HITS FROM THE GENUS OF Arisaema AGAINST HUMAN RHINO VIRUS

Kant

Lal

Ghosh

2016

Proceedings of the 20th International Electronic Conference on Synthetic Organic Chemistry

View full text Add to dashboard Cite

Human rhino viruses (HRVs) serve as an imperative precursor for frequent cases of the common cold among children worldwide. An in-silico molecular docking attempt was made of some chief phytochemical entities (Arisaema plant species) as inhibitors of HRVs with selective therapeutic target action and minimal side effects. Around 60 phytoconstituents of different Arisaema species were docked against HRV receptor (PDB: 2XYA). Binding conformers of test ligands were compared with internal ligand. Finally, Syringaresinol 4'-O-β-D-glucopyranoside (glide score: -10.86), Rutin (glide score: -9.04) & Apigenin-6,8-di-C-β-D-glucopyranoside (glide score: -7.88) have resulted in most promising hits which can be further act as an effective template to experimentally validate or further designed their choosy and budding analogue agents against HRVSs.

show abstract

“…25 The structure of abiesatrine A 20 was confirmed by X-ray analysis. 32 The 30-nor derivatives 35 and 36 have been known synthetically for many years. 26 Other new lanostanes include oenotheralanosterols A 28 and B 29 from the roots of Oenothera biennis, 27 the 24-methyl lanostane derivatives 30 and 31 from the bulbs of the orchid Prosthechea michuacana, 28 sexangulic acid 32 from the Chinese mangrove Bruguiera sexangula, 29 pisticialanstenoic acid 33 from the galls of Pistacia integerrima, 30 scolopianate A (which is methyl lucidenate N) 34 from the stems of Scolopia chinensis 31 and 30-norlanost-5-en-3bol 35 and the corresponding 3-ketone 36 from Arisaema jacquemontii.…”

Section: The Lanostane Groupmentioning

confidence: 99%

Triterpenoids

Hill

Connolly

2012

Nat. Prod. Rep.

View full text Add to dashboard Cite

show abstract

New triterpenoids from Arisaema jacquemontii

Abstract: Phytochemical investigation of the roots of Arisaema jacquemontii led to the isolation of two new triterpenoids, which were characterized by NMR, IR, and MS spectra as 30-nor-lanost-5-ene-3beta-ol (1) and 30-norlanost-5-ene-3-one (2).

Cited by 14 publications

References 18 publications

Phytochemical, in-vitro biological and chemo-preventive profiling of Arisaema jacquemontii Blume tuber extracts

Phytochemical, in-vitro biological and chemo-preventive profiling of Arisaema jacquemontii Blume tuber extracts

<strong><em>IN- SILICO</em></strong><strong> DISCOVERY OF NATURAL LEAD HITS FROM THE GENUS OF <em>Arisaema</em> AGAINST HUMAN RHINO VIRUS</strong>

Triterpenoids

Contact Info

Product

Resources

About