Phytochemical, in-vitro biological and chemo-preventive profiling of Arisaema jacquemontii Blume tuber extracts

Tabassum, Saira; Zia, Muhammad; Blanco, Esperanza J. Carcahe de; Batool, Riffat; Aslam, Roohi; Hussain, Sajid; Wali, Qamar; Gulzar, Muhammad

doi:10.1186/s12906-019-2668-4

Cited by 11 publications

(6 citation statements)

References 28 publications

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“…Therefore, any substance with ability to PKI activity have significant importance in cancer research. The present results revealed the presence of potent phytochemicals in different extracts such as aqueous, methanol and ethanol which is reported to be involved in protein kinases inhibition (Naz, Kazmi, & Zia, 2019;Tabassum et al, 2019).…”

Section: Protein Kinase Inhibition (Pki) Assaymentioning

confidence: 53%

Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

Zahra

Iqbal

Abbasi

et al. 2021

Microscopy Res & Technique

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Lactuca orientalis (Boiss.) Boiss. is one of the most frequently used ethnomedicinal plant. This research study was designed to decipher the phytochemical screening, pharmacological potential and implementation of scanning electron microscope (SEM). Six different solvents were used to prepare L. orientalis (LO) seed extracts.Phytochemical and antioxidant activities were determined calorimetrically. To investigate antidiabetic, α-amylase inhibition assay was performed. Brine shrimp assay was performed for cytotoxicity and anti-leishmanial via MTT assay. Disc-diffusion assay was performed to detect protein kinase inhibitory, antibacterial and antifungal activities. SEM was used as identification tool. Significant amount of phenolic and flavonoid content were identified in methanol extract (LOSM) (95.76 ± 3.71 GAE/mg) and (77 ± 3.60 QE/mg). Highest DPPH scavenging potential (82%) was reported for LOSM. Significant total antioxidant capacity (90.60 ± 1.55 AAE/mg) and total reducing power (94.44 ± 1.38 AAE/mg) were determined for LOSM. Highest α-amylase inhibition was found in LOSM (78.20 ± 1.58%). The highest LD 50 of brine shrimp was found for n-Hexane extract (LOSH) 13.03 μg/ml. All extracts showed strong antileishmanial activity except LOSH. L. orientalis seeds showed significant protein kinase inhibition, antibacterial and antifungal activities. The seeds of L. orientalis were seen to be oblong to obovate, projections, wavy slightly straight, anticlinal wall was raised with apex acuminate. The outer-periclinal wall convex with fine texture. In conclusion, our findings scientifically support ethnomedicinal and biological potentials of L. orientalis seeds. In future, L. orientalis seeds need to be explored for identification and isolation of bioactive compounds. The results obtained necessitate further in vivo studies to evaluate their pharmacological potentials. Key points• An extensive phytochemical potential study on the seeds of novel medicinal plant Lactuca orientalis (Boiss.) Boiss. was reported.• Scanning electron microscopy was used as an identification tool and reported for the first time for seeds of L. orientalis.

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Section: Protein Kinase Inhibition (Pki) Assaymentioning

confidence: 53%

Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

Zahra

Iqbal

Abbasi

et al. 2021

Microscopy Res & Technique

View full text Add to dashboard Cite

show abstract

“…Therefore, any substance with ability to protein kinase inhibition (PKI) activity have significant importance in cancer research. The present results revealed the presence of potent phytochemicals in different extracts such as aqueous, methanol, and ethanol which is reported to be involved in protein kinases inhibition (Naz, Kazmi, & Zia, 2019;Tabassum et al, 2019).…”

Section: Protein Kinase Inhibition Assaymentioning

confidence: 53%

Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials

Zahra

Iqbal

Abbasi

et al. 2021

Microscopy Res & Technique

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Sophora alopecuroides L. is a highly medicinal plant. The aim of the current study was to determine the phytochemical screening, pharmacological potentials and application of scanning electron microscope (SEM) of S. alopecuroides (SA) seeds. To achieve this purpose, six different solvents were used to prepare SA seed extracts. Phytochemical and antioxidant activities were determined calorimetrically. To investigate the antidiabetic activity, α-amylase inhibition assay was determined. Brine shrimp assay was used to determine cytotoxicity potential. Anti-leishmanial potential was confirmed using MTT assay. Disc-diffusion method was used to detect protein kinase inhibitory, antibacterial and antifungal activities and showed significant results. SEM analysis was used as an identification tool. Considerable amount of phenolic and flavonoid contents were identified in methanol extract (SASM) (93.76 ± 2.71 GAE/mg) and (77 ± 3.60 QE/mg). Highest DPPH scavenging potential (82%) was reported for SASM. Significant total antioxidant capacity (90.60 ± 1.55 alpha amylase enzyme [AAE]/mg) and total reducing power (94.44 ± 1.38 AAE/mg) were determined for LOSM. Highest α-amylase inhibition was reported in SASM (78.20 ± 1.58%). Highest LD 50 of brine shrimp was found for n-hexane extract (SASH) 13.03 μg/ml. All extracts showed strong anti-leishmanial activity except SASH. The seeds of SA were seen to be oblong to obovate, projections, wavy slightly straight, anticlinal wall was raised with apex acuminate. In conclusion, our experimental findings highly support the ethnomedicinal and biological potentials of the SA seeds. Moreover, SA seeds need to be explored for identification and isolation of bioactive compounds. In future, we recommend further in vivo toxicity assays and clinical efficacies to further evaluate its different biomedical properties.

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“…Administration of EIA or CIA along with DMBA (Group IV and Group V) had improved the total antioxidant power, GSH level and lowered TBARS level in plasma. The free radical scavenging property and antioxidant enhancing capacity of the extract would have played a role in its chemopreventive action, as reported earlier using various phytochemicals 19,20 .…”

Section: Fig 1: Tbars Gsh Level and Total Antioxidant Power (Frap) In...mentioning

confidence: 57%

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2022

IJPSR

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Oral cancer is the sixth leading cancer globally and the leading carcinoma in the Indian subcontinent. The relatively high incidence is due to usage of tobacco, and exposure to carcinogens are frontrunners of oxidative stress-induced DNA damage. The practice of chemopreventive agents is considered to be alternative oral carcinoma. A study on novel natural chemo preventive agent-Indigofera Aspalathoides was undertaken to evaluate its preventive chemo effect. Male Syrian Golden hamsters aged 10-12 weeks and weighing about 80-100 g were selected. Group 1were control; Group II hamsters were given Intragastric administration of ethanolic fraction of IA; Groups III had Intragastric administration of chloroform fraction of IA, Group IV had Intragastric administration of E IA + DMBA ,Group V had DMBA + Intragastric administration of CIA, and Group VI with DMBA alone. Total antioxidant power and extend of lipid peroxidation was measured by gold standard methods. Our study suggests that both EIA and CIA had a significant anticancer and preventive chemo effect against squamous cell carcinoma. Elevation in the extent of lipid peroxidation and the decrease in the levels of antioxidants were observed in the plasma of DMBA alone treated animals. This study suggests that elevation in the extent of lipid peroxidation and the decrease in the levels of antioxidants were observed in the plasma of DMBA alone treated animals. INTRODUCTION:Oral cancer refers to a subgroup of head and neck malignancies that develop at the lips, tongue, salivary gland, gingiva, floor of the mouth, oropharynx, buccal surfaces and QUICK RESPONSE CODE

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Phytochemical, in-vitro biological and chemo-preventive profiling of Arisaema jacquemontii Blume tuber extracts

Cited by 11 publications

References 28 publications

Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials

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