New Triterpenoids from the Fruiting Bodies of <i>Ganoderma lucidum</i> and Their Bioactivities

Liu, Dong‐Ze; Zhu, Yi‐Qun; Li, Xiaofei; Shan, Wei‐Gang; Gao, Pengfei

doi:10.1002/cbdv.201400004

Cited by 25 publications

(4 citation statements)

References 15 publications

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“…Additionally, there are more than 100 kinds of triterpene compounds isolated from Ganoderma fruiting bodies, spores and mycelium (especially fruiting bodies). However, the constituents of the triterpenes from the three different sources are different, and most of the triterpenes or TAs with biological activities are isolated from the fruiting bodies of Ganoderma [4,22,23,24,25,26,27,28,29], and whether the triterpenes or TAs prepared from submerged culture Ganoderma (especially G. lingzhi ) mycelium possesses antitumor activity needs to be further proved.…”

Section: Introductionmentioning

confidence: 99%

Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi

et al. 2016

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Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative production of TAs has not been optimized for commercial use, and whether the TAs isolated from G. lingzhi submerged culture mycelia possess antitumor activity needs to be further proven. In this study, enhanced TA yield and productivity were attained with G. lingzhi using response surface methodology. The interactions of three variables were studied using a Box-Benhnken design, namely initial pH, dissolved oxygen (DO) and fermentation temperature. The optimum conditions were an initial pH of 5.9, 20.0% DO and 28.6 ○ C. These conditions resulted in a TA yield of 308.1 mg/L in a 5-L stirred bioreactor. Furthermore, the optimized conditions were then successfully scaled up to a production scale of 200 L, and maximum TA production and productivity of 295.3 mg/L and 49.2 mg/L/day were achieved, which represented 80.9% and 111.5% increases, respectively, compared with the non-optimized conditions. Additionally, the triterpene acid extract (TAE) from G. lingzhi mycelia was found to be cytotoxic to the SMMC-7721 and SW620 cell lines in vitro, and the TAE exhibited dose-dependent antitumor activity against the solid tumor sarcoma 180 in vivo. Chemical analysis revealed that the key active triterpene compounds, ganoderic acid T and ganoderic acid Me, predominated in the extract.

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Section: Introductionmentioning

confidence: 99%

Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi

et al. 2016

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“…Outbreaks of EV71 infection have been periodically reported worldwide [ 154 , 155 , 156 ]. For instance, China has recently seen increased deaths linked to EV71 infection and HFMD among the young population [ 131 , 138 , 157 , 158 ]. As mentioned above, there are no approved drugs for preventing or treating EV71 infection, but currently, antiviral drugs with a broad spectrum (e.g., acyclovir, ganciclovir, and ribavirin) are used to partially relieve infection symptoms, although they have high cytotoxic side effects [ 159 ].…”

Section: Ganoderma Lucidum As a Functional Foodmentioning

confidence: 99%

Nutritional Profile and Health Benefits of Ganoderma lucidum “Lingzhi, Reishi, or Mannentake” as Functional Foods: Current Scenario and Future Perspectives

Sheikha

2022

Foods

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Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more than 2000 years due to its healing properties. Recently, G. lucidum has come under scientific scrutiny to evaluate its content of bioactive components that affect human physiology, and has been exploited for potent components in the pharmacology, nutraceuticals, and cosmetics industries. For instance, evidence is accumulating on the potential of this mushroom species as a promising antiviral medicine for treating many viral diseases, such as dengue virus, enterovirus 71, and recently coronavirus disease of 2019 (COVID-19). Still, more research studies on the biotherapeutic components of G. lucidum are needed to ensure the safety and efficiency of G. lucidum and promote the development of commercial functional foods. This paper provides an extensive overview of the nutraceutical value of Ganoderma lucidum and the development of commercial functional food. Moreover, the geo-origin tracing strategies of this mushroom and its products are discussed, a highly important parameter to ensure product quality and safety. The discussed features will open new avenues and reveal more secrets to widely utilizing this mushroom in many industrial fields; i.e., pharmaceutical and nutritional ones, which will positively reflect the global economy.

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“…The antistaphylococcal activity of extracts from fruiting body of G. lucidum strain was represented by inhibition zone diameter ranging from 2.2 to 2.5 cm recorded against S. aureus [15]. The isolated compound, 12β-acetoxy-3β, 7β-dihydroxy-11, 15, 23-trioxolanost-8-en-26-oic acid butyl ester (1) from G. lucidum displayed MIC value of 68.5 um against S. aureus [70]. Ganoderma pfeifferi is one of the phytochemically less investigated species of the family Ganodermataceae.…”

Section: Antistaphylococcal Natural Products From Basidiomycetesmentioning

confidence: 99%

A Review on Antistaphylococcal Secondary Metabolites from Basidiomycetes

et al. 2020

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Fungi are a rich source of secondary metabolites with several pharmacological activities such as antifungal, antioxidant, antibacterial and anticancer to name a few. Due to the large number of diverse structured chemical compounds they produce, fungi from the phyla Ascomycota, Basidiomycota and Muccoromycota have been intensively studied for isolation of bioactive compounds. Basidiomycetes-derived secondary metabolites are known as a promising source of antibacterial compounds with activity against Gram-positive bacteria. The continued emergence of antimicrobial resistance (AMR) poses a major challenge to patient health as it leads to higher morbidity and mortality, higher hospital-stay duration and substantial economic burden in global healthcare sector. One of the key culprits for AMR crisis is Staphylococcus aureus causing community-acquired infections as the pathogen develops resistance towards multiple antibiotics. The recent emergence of community strains of S. aureus harbouring methicillin-resistant (MRSA), vancomycin-intermediate (VISA) and vancomycin-resistant (VRSA) genes associated with increased virulence is challenging. Despite the few significant developments in antibiotic research, successful MRSA therapeutic options are still needed to reduce the use of scanty and expensive second-line treatments. This paper provides an overview of findings from various studies on antibacterial secondary metabolites from basidiomycetes, with a special focus on antistaphylococcal activity.

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New Triterpenoids from the Fruiting Bodies of Ganoderma lucidum and Their Bioactivities

Cited by 25 publications

References 15 publications

Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi

Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi

Nutritional Profile and Health Benefits of Ganoderma lucidum “Lingzhi, Reishi, or Mannentake” as Functional Foods: Current Scenario and Future Perspectives

A Review on Antistaphylococcal Secondary Metabolites from Basidiomycetes

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