New tuberculosis drug leads from naturally occurring compounds

Abstract

Tuberculosis (TB) continues to be a significant cause of mortality and morbidity worldwide. An estimated 2 billion individuals are infected with Mycobacterium tuberculosis and annually there are approximately 10 million new cases of clinical TB and 1.5 million deaths. Currently available drugs and vaccines have had no significant impact on TB control. In addition, the emergence of drug resistant TB is considered a public health crisis, with some strains now resistant to all available drugs. Unfortunately, the growing burden of antibiotic resistance is coupled with decreased effort in the development of new antibiotics. Natural sources are attractive starting points in the search for anti-tubercular drugs because they are extremely rich in chemical diversity and have privileged antimicrobial activity. This review will discuss recent advances in the development of TB drug leads from natural products, with a particular focus on anti-mycobacterial compounds in late-stage preclinical and clinical development.

Structures of theMycobacterium tuberculosisGlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition

“…Tuberculosis (TB) affects two billion individuals, with ten million new cases and 1.5 million deaths reported each year (Quan et al, 2017). Multidrug-resistant, extensively drugresistant and totally drug-resistant strains of tuberculosis complicate the already tedious treatment protocol (Balganesh et al, 2008).…”

1,3‐Oxazole‐isoniazid hybrids: Synthesis, antitubercular activity, and their docking studies

“…Natural products are extremely useful templates for the development of a number of the new drug molecules and they have received immense attention as potential anti‐TB agents . Various natural products have been reported to show resistant against strains of Mycobacterium tuberculosis . No new anti‐TB drugs have been developed in the TB therapy in the course of the past few years, creating an urgent need of design and developing of new drugs and strategies for an effective TB treatment.…”

Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants

“…Recent studies have shown the potential of natural extracts as the basis for new drugs [6,7]. Microorganisms and plants have exceptional chemical and structural diversity and represent a valuable source of biologically active molecules with potential as new antimicrobials [8].…”