New type of oscillatory processes—oxidative carbonylation of alkynes in the homogeneous catalysis by Pd complexes. Phenylacetylene

Gorodsky, Sergey N.

doi:10.1007/s11144-017-1300-1

Cited by 3 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The vision behind the development of such autonomous pulsatile materials is to achieve in vivo pulsatile drug delivery, required in chronopharmacotherapy, and mechanoresponsive tissue regeneration. While intelligent hydrogels attract significant interest enhancing progress in that area [8][9][10][11], the study of oscillatory chemical reactions [7,12,13], particularly oscillatory carbonylation reactions, remains the painstaking effort of a small community [14][15][16][17][18][19][20]. The oscillatory palladium-catalyzed oxidative carbonylation reaction (PCOC) readily proceeds under mild temperatures (0-40 °C) and atmospheric pressure in batch and can sustain oscillations in pH, redox properties and turbidity over a prolonged period of time (monitored up to a month) [21,22].…”

Section: Introductionmentioning

confidence: 99%

Broadening the scope of Pd-catalyzed oscillatory carbonylation reactions: solvent, substrate, catalyst

Isakova

Parker

Nwosu

et al. 2019

Reac Kinet Mech Cat

View full text Add to dashboard Cite

On our way to producing all-polymeric self-oscillatory materials, we have expanded the horizons of oscillatory carbonylation reactions by searching for alternative substrates, solvents and even catalysts. In this paper, we demonstrate that pH oscillations in carbonylation reactions have the potential to occur in a broad range of aliphatic alcohol solutions when using either a small molecule substrate (phenylacetylene) or a polymeric substrate (pegylated alkyne) with either a small molecule catalyst (Pd-diacetate) or a non-leaching polymeric catalyst (Pd-polyacrylate). The alcohols studied are methanol, ethanol, 1-propanol, 1-butanol and 1-hexanol. In this carbonylation reaction an alcohol serves as both the solvent and as a reactant. The resulting oscillations suggest that carbonylation reactions have strong potential for the discovery and development of new oscillatory chemical systems. Replacing methanol, commonly used in oscillatory carbonylation processes, with ethanol is an important step in enhancing the biocompatibility of these systems. Furthermore, showing that oscillations in pH are feasible in ethanol solutions when polymeric substrate and polymeric catalyst are used supports the vision of employing oscillatory chemical reactions to build oscillatory materials.

show abstract

Section: Introductionmentioning

confidence: 99%

Broadening the scope of Pd-catalyzed oscillatory carbonylation reactions: solvent, substrate, catalyst

Isakova

Parker

Nwosu

et al. 2019

Reac Kinet Mech Cat

View full text Add to dashboard Cite

show abstract

“…Oscillatory reactions are considered to be a powerful avenue for a smart self-pulsatile polymeric systems, if coupled to the right pH-, redox-or thermo-responsive polymer or hydrogel for a grand number of potential biomimetic applications [1][2][3]. Of the reported oscillatory reactions [4][5][6][7][8], palladium-catalysed oxidative carbonylation (PCOC) of alkynes (Scheme 1) is attracting attention as one of the most versatile reactions, capable of producing sustained (for up to one month of monitoring) oscillations in pH, redox potential, turbidity, and heater power (measured by power compensation calorimetry), where the amplitude and period can be successfully regulated by adjusting the reactant composition or temperature [9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%