New understanding of the pathogenesis and treatment of stroke-related sarcopenia

Li, Wei; Tao, Yue; Liu, Yanming

doi:10.1016/j.biopha.2020.110721

Cited by 68 publications

(51 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, sarcopenia caused by aging further reduces muscle strength, limiting the activities of daily life and resulting in decreased HRQOL. [35][36][37][38][39] In addition, social interaction decreases and psychological conditions such as depression worsen with age, which further adversely affects HRQOL. 19) Among the factors examined in this study, the controllable factors were smoking, alcohol intake, and walking.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Knee Osteoarthritis and Health-Related Quality of Life in Stroke Patients over 60 Years Old: A Cross-Sectional Study Using Korean National Health and Nutrition Examination Survey V

Jeong

Lee

2021

Ann Geriatr Med Res

View full text Add to dashboard Cite

Background: This study investigated the prevalence of knee osteoarthritis among stroke survivors aged over 60 years and analyzed the association between knee osteoarthritis and health-related quality of life (HRQOL) in stroke survivors. Methods: We analyzed data of 287 participants who had experienced a stroke (stroke group) from the 2010-2012 Korean National Health and Nutrition Examination Survey. Among the participants, 65 stroke survivors also had knee osteoarthritis. We used the European Quality of Life-5 Dimensions (EQ-5D) questionnaire to compare the differences in HRQOL according to the presence or absence of knee osteoarthritis in the stroke group. Multiple regression analysis was performed to determine associated factors affecting HRQOL in the stroke group. Results: The prevalence of knee osteoarthritis was 21% in the stroke group. The EQ-5D index score was significantly lower in patients in the stroke group with knee osteoarthritis than in those without knee osteoarthritis (adjusted mean ±standard error [SE], 0.680±0.011 for stroke with knee osteoarthritis and 0.817±0.003 stroke without knee osteoarthritis; p<0.0001). Knee osteoarthritis, age, income level, education level, smoking, diabetes, and cardiovascular disease significantly influenced HRQOL in the stroke group. Conclusion: The study results confirmed that the prevalence of knee osteoarthritis was 21% in the stroke group and that HRQOL was significantly lower among patients in the stroke group with knee osteoarthritis. These findings suggest the importance of active management of knee osteoarthritis in stroke survivors for HRQOL.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of Knee Osteoarthritis and Health-Related Quality of Life in Stroke Patients over 60 Years Old: A Cross-Sectional Study Using Korean National Health and Nutrition Examination Survey V

Jeong

Lee

2021

Ann Geriatr Med Res

View full text Add to dashboard Cite

show abstract

“…In healthy people, muscle tissue is gradually lost during aging, resulting in a decrease in mass and strength, a condition described as sarcopenia ( 8 ). In specific pathological conditions, especially in those that may invoke inflammatory processes, disease-related immobility or malnutrition, sarcopenia can occur as secondary, defining a “specific sarcopenia” ( 6 ). Recently, the muscle atrophy, consequent to the stroke has been defined as a new condition called “stroke-induced sarcopenia” or “stroke-related sarcopenia”; it has also been associated with worse clinical outcomes and physical dysfunction ( 6 , 9 ).…”

Section: Morphological Changesmentioning

confidence: 99%

“…Traditionally, the rehabilitation effort has been oriented toward the treatment of the central nervous system (CNS) damage with a central approach, which exploits the plastic capacity of the neural cells to recover the best motor control. In this paradigm, muscle tissue is often overlooked ( 6 ). In our opinion, to ensure greater effectiveness of rehabilitation, new protocol approaches are needed, focused on muscle modifications over time.…”

Section: Introductionmentioning

confidence: 99%

How Does Stroke Affect Skeletal Muscle? State of the Art and Rehabilitation Perspective

2021

View full text Add to dashboard Cite

Long-term disability caused by stroke is largely due to an impairment of motor function. The functional consequences after stroke are caused by central nervous system adaptations and modifications, but also by the peripheral skeletal muscle changes. The nervous and muscular systems work together and are strictly dependent in their structure and function, through afferent and efferent communication pathways with a reciprocal “modulation.” Knowing how altered interaction between these two important systems can modify the intrinsic properties of muscle tissue is essential in finding the best rehabilitative therapeutic approach. Traditionally, the rehabilitation effort has been oriented toward the treatment of the central nervous system damage with a central approach, overlooking the muscle tissue. However, to ensure greater effectiveness of treatments, it should not be forgotten that muscle can also be a target in the rehabilitation process. The purpose of this review is to summarize the current knowledge about the skeletal muscle changes, directly or indirectly induced by stroke, focusing on the changes induced by the treatments most applied in stroke rehabilitation. The results of this review highlight changes in several muscular features, suggesting specific treatments based on biological knowledge; on the other hand, in standard rehabilitative practice, a realist muscle function evaluation is rarely carried out. We provide some recommendations to improve a comprehensive muscle investigation, a specific rehabilitation approach, and to draw research protocol to solve the remaining conflicting data. Even if a complete multilevel muscular evaluation requires a great effort by a multidisciplinary team to optimize motor recovery after stroke.

show abstract

“…In recent years, more attention has been given to research about the modifications in the characteristics of the muscle tissue after a stroke [ 8 ]. In this context, stroke-related sarcopenia is characterized by a rapid decline in muscle mass after onset, muscle fiber-type shifts, determining bilateral differences in the physical and functional performance of brain lesions, impaired feeding and complex systemic metabolic changes [ 7 , 9 ]. Stroke-related sarcopenia has been described in a variety of settings, with a prevalence of 16.8% in the community [ 10 ] and 48.3–60.3% in the convalescent rehabilitation ward [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Improvement in Sarcopenia on Functional and Discharge Outcomes in Stroke Rehabilitation Patients

Matsushita¹,

Nishioka²,

Taguchi³

et al. 2021

Nutrients

View full text Add to dashboard Cite

This cross-sectional study investigated the proportion of patients’ recovery from sarcopenia status and the relationship between improvement in sarcopenia (IS) and function and discharge outcome in hospitalized patients with stroke. This study included patients with stroke, aged 65 years or more, with a diagnosis of sarcopenia, who were admitted to a convalescent rehabilitation ward. Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia 2019 criteria. Patients were divided according to the presence or absence of sarcopenia at discharge: IS group and non-improvement in sarcopenia (NIS) group. Among the 227 participants (mean age: 80.5 years; 125 females), 30% (69/227) of the patients were in the IS group, while 70% (158/227) were in the NIS group. The IS group showed a higher Functional Independence Measure (FIM) than the NIS group (median 112 vs. 101, p = 0.003). The results demonstrated that IS was independently associated with higher FIM (partial regression coefficient, 5.378; 95% confidence interval (CI), 0.709–10.047). The IS group had higher odds of home discharge than the NIS group (odds ratio, 2.560; 95% CI, 0.912–7.170). In conclusion, recovery from sarcopenia may be associated with better function in patients with stroke.

show abstract

New understanding of the pathogenesis and treatment of stroke-related sarcopenia

Cited by 68 publications

References 79 publications

Prevalence of Knee Osteoarthritis and Health-Related Quality of Life in Stroke Patients over 60 Years Old: A Cross-Sectional Study Using Korean National Health and Nutrition Examination Survey V

Prevalence of Knee Osteoarthritis and Health-Related Quality of Life in Stroke Patients over 60 Years Old: A Cross-Sectional Study Using Korean National Health and Nutrition Examination Survey V

How Does Stroke Affect Skeletal Muscle? State of the Art and Rehabilitation Perspective

Effect of Improvement in Sarcopenia on Functional and Discharge Outcomes in Stroke Rehabilitation Patients

Contact Info

Product

Resources

About