New Variants of Malignant Glioneuronal Tumors: A Clinicopathological Study of 40 Cases

Varlet, Pascale; Soni, Dheeraj; Miquel, Catherine; Roux, François‐Xavier; Méder, Jean-François; Chneiweiss, Hervé; Daumas-Duport, Cathérine

doi:10.1227/01.neu.0000143033.36582.40

Cited by 88 publications

(92 citation statements)

References 44 publications

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“…In a study performed by Valret et al on malignant glioneuronal tumors (MGNTs), all tumors coexpressed GFAP and NFP, in which NFP immunostaining was performed without antigen retrieval. The staining result was poor (10/12) in comparison with tumors stained with antigen retrieval (Varlet et al, 2004). In our study, to decrease false negative results, once the sections were stained without antigen retrieval and again were stained with antigen retrieval.…”

Section: Discussionmentioning

confidence: 61%

“…Other studies found that the antigen retrieval process may induce nonspecific immunostanining (Varlet et al, 2004). In a study performed by Valret et al on malignant glioneuronal tumors (MGNTs), all tumors coexpressed GFAP and NFP, in which NFP immunostaining was performed without antigen retrieval.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed controversial results. In a study performed by Varlet et al neuronal differentiation was evaluated in 40 patients with astrocytomas and found that all of the tumors were NFP and GFAP positive (Varlet et al, 2004). Pallud et al revealed that NFP could be helpful in determination of a special subgroup of GBMs and that NFP can be a reliable marker for prediction of survival (Pallud et al, 2012).…”

Section: Expression Of Neuronal Markers Nfp and Gfap In Malignant Amentioning

confidence: 99%

See 2 more Smart Citations

Expression of Neuronal Markers, NFP and GFAP, in Malignant Astrocytoma

Hashemi¹,

Naderian²,

Kadivar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Expression Of Neuronal Markers Nfp and Gfap In Malignant Amentioning

confidence: 99%

See 1 more Smart Citation

Expression of Neuronal Markers, NFP and GFAP, in Malignant Astrocytoma

Hashemi¹,

Naderian²,

Kadivar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…A study of 40 cases of grade III or IV glioma demonstrated coexpression of GFAP and NFP as essential to the diagnosis of GBM-PNET [165]. Furthermore, a lack of recurrence was observed in 36% of cases, which underwent gross total resection resulting in a mean survival of 44 months.…”

Section: Glioblastoma Multiforme With Primitive Neuroectodermal Featuresmentioning

confidence: 99%

Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features

Karsy¹,

Gelbman²,

Shah³

et al. 2012

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A b s t r a c t Since the recent publication of the World Health Organization brain tumour classification guidelines in 2007, a significant expansion in the molecular understanding of glioblastoma multiforme (GBM) and its pathological as well as genomic variants has been evident. The purpose of this review article is to evaluate the histopathological, molecular and clinical features surrounding emerging and currently established GBM variants. The tumours discussed include classic glioblastoma multiforme and its four genomic variants, proneural, neural, mesenchymal, classical, as well as gliosarcoma (GS), and giant cell GBM (gcGBM). Furthermore, the emerging variants include fibrillary/epithelial GBM, small cell astrocytoma (SCA), GBM with oligodendroglial component (GBMO), GBM with primitive neuroectodermal features (GBM-PNET), gemistocytic astrocytoma (GA), granular cell astrocytoma (GCA), and paediatric high-grade glioma (HGG) as well as diffuse intrinsic pontine glioma (DIPG

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“…[Table6] As the clinical and histopathological properties of those tumors have been described only recently, the number of cases reported in the literature is limited. The largest series published on these tumors belong to Varlet et al [ 21] (n=40) and Perry et al (22) (n=53). These studies highlighted the clinical, radiological, and histopathological differences of GB-PNET from classic GBM.…”

Section: Discussionmentioning

confidence: 99%

GlioblastomaMultiforme: A clinico-pathological analysis

Shenoy

Singhal

2017

APALM

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Background: Aim of the study was to classify Glioblastoma Multiforme (GBM) and its variants on histology and analyze their clinicopathological features. Better understanding of the heterogeneous nature of GBM and its variants may provide improved treatment paradigms, prognostic classification and approaches towards molecular targeted treatments.Methods: 40 cases of GBM were analyzed retrospectively and prospectively, covering a period of 8 years (January 2008-July2015). Cases were analyzed on the basis of clinical presentation, histopathological features and radiological reports. Results:Of the 40 cases of GBM, the Conventional GBM, GBM with oligodendroglial component, Giant Cell GBM accounted for 26, 9 and 3 cases respectively. While there was 1 case each of Gliosarcoma and P-NET variants. Conventional GBM most commonly presented with Headache (69.2%) and paresis (57.7%) whereas GBMO patients presented with convulsions. On radiology, the variants of GBM cannot be distinguished as the findings were similar in all of them. Non-palisading necrosis was predominantly present in Conventional GBM (61.5%) and palisading necrosis in GBMO (66.7%). Conclusion:Histopathology remains the main tool for differentiating the variants as radiological differentiation is not possible due to similar appearing features.

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New Variants of Malignant Glioneuronal Tumors: A Clinicopathological Study of 40 Cases

Cited by 88 publications

References 44 publications

Expression of Neuronal Markers, NFP and GFAP, in Malignant Astrocytoma

Expression of Neuronal Markers, NFP and GFAP, in Malignant Astrocytoma

Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features

GlioblastomaMultiforme: A clinico-pathological analysis

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